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Product Details
PA1-84182
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant human RANTES.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2071185
Product Specific Information
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. This antibody may be used in Western Blotting applications under either reducing or non-reducing conditions.
Reconstitute with 0.1 mL of distilled water. For long term storage the addition of 0.09% sodium azide is recommended. Prior to reconstitution, store at 4° C. After reconstitution, store undiluted at -20° C, avoiding freeze/thaw cycles.
Rabbit anti Human RANTES antibody recognizes human RANTES (regulated upon activation, normal T cell expressed and secreted), otherwise known as CCL5, a 68 amino acid CC- chemokine involved in T cell activation and cell recruitment, expressed by cytotoxic (CD8+) T cells (CTLs), macrophages, keratinocytes and endothelial cells.
Target Information
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-chemokine RANTES; C-C motif chemokine 5; chemokine (C-C motif) ligand 5; EoCP; Eosinophil chemotactic cytokine; MGC17164; OTTHUMP00000197106; regulated upon activation, normally T-expressed, and presumably secreted; SIS δ; SIS-delta; SISδ; small inducible cytokine subfamily A (Cys-Cys), member 5; Small-inducible cytokine A5; T cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228
Gene Aliases: CCL5; D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228
UniProt ID: (Human) P13501
Entrez Gene ID: (Human) 6352
phosphatidylinositol phospholipase C activity
protein kinase activity
protein binding
chemokine activity
heparin binding
phospholipase activator activity
receptor signaling protein tyrosine kinase activator activity
CCR1 chemokine receptor binding
CCR4 chemokine receptor binding
CCR5 chemokine receptor binding
chemoattractant activity
chemokine receptor binding
protein homodimerization activity
protein self-association
chemokine receptor antagonist activity
cytokine
intercellular signal molecule
MAPK cascade
dendritic cell chemotaxis
chronic inflammatory response
monocyte chemotaxis
regulation of chronic inflammatory response
calcium ion transport
cellular calcium ion homeostasis
exocytosis
chemotaxis
inflammatory response
leukocyte cell-cell adhesion
G-protein coupled receptor signaling pathway
cell-cell signaling
aging
response to virus
response to toxic substance
response to salt stress
positive regulation of activation of JAK2 kinase activity
positive regulation of macrophage chemotaxis
positive regulation of T cell chemotaxis
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
positive regulation of smooth muscle cell migration
dibenzo-p-dioxin metabolic process
positive regulation of cell migration
neutrophil chemotaxis
positive regulation of cellular biosynthetic process
activation of phospholipase D activity
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
response to insulin
positive regulation of cell-cell adhesion mediated by integrin
positive regulation of homotypic cell-cell adhesion
positive regulation of T cell proliferation
neutrophil activation
positive regulation of phosphorylation
response to drug
positive regulation of tyrosine phosphorylation of STAT protein
protein kinase B signaling
positive regulation of GTPase activity
cellular protein complex assembly
response to estrogen
negative regulation by host of viral transcription
cellular response to fibroblast growth factor stimulus
positive regulation of viral genome replication
negative regulation of viral genome replication
positive regulation of innate immune response
positive regulation of neuron differentiation
positive regulation of osteoclast differentiation
negative regulation of G-protein coupled receptor protein signaling pathway
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of translational initiation
positive regulation of JAK-STAT cascade
eosinophil chemotaxis
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of inflammatory response
regulation of insulin secretion
regulation of T cell activation
positive chemotaxis
protein tetramerization
response to glucocorticoid
positive regulation of calcium ion transport
positive regulation of mast cell chemotaxis
positive regulation of protein tyrosine kinase activity
chemokine-mediated signaling pathway
negative regulation of chemokine-mediated signaling pathway
negative regulation of T cell apoptotic process
positive regulation of T cell apoptotic process
positive regulation of ERK1 and ERK2 cascade
response to cholesterol
cellular response to amino acid stimulus
cellular response to vitamin K
cellular response to morphine
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to ethanol
cellular response to high density lipoprotein particle stimulus
cellular response to organic cyclic compound
cellular response to alkyl hydroperoxide
cellular response to transforming growth factor beta stimulus
positive regulation of monocyte chemotaxis
regulation of neuron death
negative regulation of neuron death
negative regulation of macrophage apoptotic process
positive regulation of T cell migration
positive regulation of natural killer cell chemotaxis
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