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Product Details
MA5-23750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
53433
Immunogen
E. coli-derived recombinant mouse CCL5/RANTES Ser24-Ser91
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608991
Product Specific Information
This antibody detects recombinant mouse (rm)CCL5 direct ELISAs. In sandwich ELISAs, approximately 5% cross-reactivity with rhCCL5 and less than 0.2% cross-reactivity with rhTECK and rhVIC was observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C motif chemokine 5; MGC17164; MuRantes; OTTHUMP00000197106; SIS δ; SIS-delta; SISδ; small inducible cytokine A5; Small-inducible cytokine A5; T-cell-specific protein RANTES
Gene Aliases: Ccl5; MuRantes; RANTES; Scya5; SISd; TCP228
UniProt ID: (Mouse) P30882
Entrez Gene ID: (Mouse) 20304
phosphatidylinositol phospholipase C activity
protein kinase activity
cytokine activity
chemokine activity
heparin binding
phospholipase activator activity
receptor signaling protein tyrosine kinase activator activity
CCR1 chemokine receptor binding
CCR5 chemokine receptor binding
chemoattractant activity
chemokine receptor binding
protein homodimerization activity
protein self-association
chemokine receptor antagonist activity
cytokine
intercellular signal molecule
MAPK cascade
positive regulation of defense response to virus by host
calcium ion transport
cellular calcium ion homeostasis
exocytosis
chemotaxis
inflammatory response
immune response
leukocyte cell-cell adhesion
G-protein coupled receptor signaling pathway
cell-cell signaling
response to toxic substance
positive regulation of gene expression
positive regulation of macrophage chemotaxis
positive regulation of T cell chemotaxis
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
positive regulation of cell migration
pseudopodium assembly
positive regulation of cellular biosynthetic process
activation of phospholipase D activity
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
positive regulation of cell-cell adhesion mediated by integrin
response to cytokine
positive regulation of homotypic cell-cell adhesion
response to interferon-gamma
response to tumor necrosis factor
T-helper 1 cell diapedesis
positive regulation of T cell proliferation
neutrophil activation
positive regulation of phosphorylation
positive regulation of tyrosine phosphorylation of STAT protein
protein kinase B signaling
cellular protein complex assembly
negative regulation by host of viral transcription
negative regulation of viral genome replication
positive regulation of neuron differentiation
positive regulation of osteoclast differentiation
negative regulation of G-protein coupled receptor protein signaling pathway
positive regulation of angiogenesis
positive regulation of cell adhesion
eosinophil chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
regulation of insulin secretion
regulation of T cell activation
positive chemotaxis
protein tetramerization
positive regulation of calcium ion transport
negative regulation of cell death
positive regulation of mast cell chemotaxis
positive regulation of protein tyrosine kinase activity
chemokine-mediated signaling pathway
negative regulation of chemokine-mediated signaling pathway
negative regulation of T cell apoptotic process
positive regulation of T cell apoptotic process
cellular response to organic cyclic compound
positive regulation of monocyte chemotaxis
extracellular negative regulation of signal transduction
regulation of neuron death
negative regulation of neuron death
negative regulation of macrophage apoptotic process
negative regulation of receptor activity
positive regulation of chemokine (C-X-C motif) ligand 2 production
positive regulation of T cell migration
positive regulation of natural killer cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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