Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
TA590132
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNA immunization. This antibody is specific for the Middle Region of the target protein.
Conjugate
Form
Liquid
Concentration
1.09 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell-surface integrins, and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CCN family member 3; Cellular communication network factor 3; IBP-9; IGF-binding protein 9; Insulin-like growth factor-binding protein 9; Nephro blastoma-overexpressed gene protein homolog; nephroblastoma-overexpressed gene protein homolog; NovH; Protein NOV homolog
Gene Aliases: CCN3; IBP-9; IGFBP-9; IGFBP9; NOV; NOVH
UniProt ID: (Human) P48745
Entrez Gene ID: (Human) 4856
angiogenesis
chondrocyte differentiation
cell-cell signaling
regulation of gene expression
fibroblast migration
negative regulation of myotube differentiation
smooth muscle cell migration
negative regulation of cell growth
cell adhesion mediated by integrin
endothelial cell chemotaxis
negative regulation of NF-kappaB import into nucleus
type B pancreatic cell proliferation
positive regulation of Notch signaling pathway
negative regulation of insulin secretion
smooth muscle cell proliferation
negative regulation of inflammatory response
cell chemotaxis
negative regulation of SMAD protein import into nucleus
negative regulation of cell death
hematopoietic stem cell homeostasis
endothelial cell-cell adhesion
negative regulation of monocyte chemotaxis
negative regulation of chondrocyte proliferation
negative regulation of sensory perception of pain
bone regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support