Proteintech

CCR2a Polyclonal Antibody

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CCR2a Antibody (16153-1-AP) in Flow

1X10^6 Jurkat cells were stained with 0.2ug CCR2-specific antibody (16153-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1000.

CCR2a Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

16153-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody 16153-1-AP is raised against the peptide of 344-358 amino acids of CCR2a. It is specific to CCR2a.

Target Information

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study.

Cancer medicine

Zhai T,Mitamura T,Wang L,Kubota SI,Murakami M,Tanaka S,Watari H

Sat Apr 01 00:00:00 EDT 2023

Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study.

Cancer medicine

Zhai T,Mitamura T,Wang L,Kubota SI,Murakami M,Tanaka S,Watari H

Sat Apr 01 00:00:00 EDT 2023

Hypoxia-induced CCL2/CCR2 axis in adipose-derived stem cells (ADSCs) promotes angiogenesis by human dermal microvascular endothelial cells (HDMECs) in flap tissues.

Journal of physiology and biochemistry

Fang B,Wang X,Sun Y,Xiong X,Meng X,Li W,Yi Z

Mon May 01 00:00:00 EDT 2023

Hypoxia-induced CCL2/CCR2 axis in adipose-derived stem cells (ADSCs) promotes angiogenesis by human dermal microvascular endothelial cells (HDMECs) in flap tissues.

Journal of physiology and biochemistry

Fang B,Wang X,Sun Y,Xiong X,Meng X,Li W,Yi Z

Mon May 01 00:00:00 EDT 2023

Hypoxia-induced CCL2/CCR2 axis in adipose-derived stem cells (ADSCs) promotes angiogenesis by human dermal microvascular endothelial cells (HDMECs) in flap tissues.

Journal of physiology and biochemistry

Fang B,Wang X,Sun Y,Xiong X,Meng X,Li W,Yi Z

Mon May 01 00:00:00 EDT 2023

Hypoxia-induced CCL2/CCR2 axis in adipose-derived stem cells (ADSCs) promotes angiogenesis by human dermal microvascular endothelial cells (HDMECs) in flap tissues.

Journal of physiology and biochemistry

Fang B,Wang X,Sun Y,Xiong X,Meng X,Li W,Yi Z

Mon May 01 00:00:00 EDT 2023

CCL2 activates AKT signaling to promote glycolysis and chemoresistance in glioma cells.

Cell biology international

Qian Y,Ding P,Xu J,Nie X,Lu B

Sun May 01 00:00:00 EDT 2022

Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling.

Laboratory investigation; a journal of technical methods and pathology

Kang SU,Cho SY,Jeong H,Han J,Chae HY,Yang H,Sung CO,Choi YL,Shin YK,Kwon MJ

Fri Apr 01 00:00:00 EDT 2022

QKI deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response.

Molecular immunology

Deng L,Wang W,Bian P,Wu M,Wang L,Lei Y,Lu Z,Zhai D

Mon Aug 01 00:00:00 EDT 2022

QKI deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response.

Molecular immunology

Deng L,Wang W,Bian P,Wu M,Wang L,Lei Y,Lu Z,Zhai D

Mon Aug 01 00:00:00 EDT 2022

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.

Cell death & disease

Ling Z,Li W,Hu J,Li Y,Deng M,Zhang S,Ren X,Wu T,Xia J,Cheng B,Tao X

Thu Feb 17 00:00:00 EST 2022

Identification of potential regulating effect of baicalin on NFκB/CCL2/CCR2 signaling pathway in rats with cerebral ischemia by antibody-based array and bioinformatics analysis.

Journal of ethnopharmacology

Xu T,Wang X,Ma C,Ji J,Xu W,Shao Q,Liao X,Li Y,Cheng F,Wang Q

Thu Feb 10 00:00:00 EST 2022

Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.

International immunopharmacology

Han Y,Xian Y,Gao X,Qiang P,Hao J,Yang F,Shimosawa T,Chang Y,Xu Q

Thu Dec 01 00:00:00 EST 2022

Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.

International immunopharmacology

Han Y,Xian Y,Gao X,Qiang P,Hao J,Yang F,Shimosawa T,Chang Y,Xu Q

Thu Dec 01 00:00:00 EST 2022

Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.

International immunopharmacology

Han Y,Xian Y,Gao X,Qiang P,Hao J,Yang F,Shimosawa T,Chang Y,Xu Q

Thu Dec 01 00:00:00 EST 2022

Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.

International immunopharmacology

Han Y,Xian Y,Gao X,Qiang P,Hao J,Yang F,Shimosawa T,Chang Y,Xu Q

Thu Dec 01 00:00:00 EST 2022

ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10.

Respiratory research

Liu Y,Zhang X,Wang J,Yang F,Luo W,Huang J,Chen M,Wang S,Li C,Zhang W,Chao J

Fri Aug 12 00:00:00 EDT 2022

Curcumin alleviates inflammation in Takayasu's arteritis by blocking CCL2 overexpression in adventitial fibroblasts.

Clinical and experimental rheumatology

Wu S,Kong X,Wang Y,Fan X,Huang Q,Chen R,Yu W,Ma L,Sun Y,Jiang L

Mon May 24 00:00:00 EDT 2021

CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.

Neuroscience

Xian H,Jiang Y,Zhang H,Ma SB,Zhao R,Cong R

Wed Jan 15 00:00:00 EST 2020

CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway.

Clinical & experimental metastasis

Yasui H,Kajiyama H,Tamauchi S,Suzuki S,Peng Y,Yoshikawa N,Sugiyama M,Nakamura K,Kikkawa F

Sat Feb 01 00:00:00 EST 2020

CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway.

Oncology reports

Zhuang H,Cao G,Kou C,Liu T

Mon Jan 01 00:00:00 EST 2018

CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway.

Oncology reports

Zhuang H,Cao G,Kou C,Liu T

Mon Jan 01 00:00:00 EST 2018

Bioinformatics

Protein Aliases: C-C chemokine receptor type 2; C-C CKR-2; Cc-ckr2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

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Gene Aliases: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R

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UniProt ID: (Human) P41597

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Entrez Gene ID: (Human) 729230

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Function(s)

chemokine receptor activity C-C chemokine receptor activity protein kinase binding CCR2 chemokine receptor binding protein homodimerization activity chemokine (C-C motif) ligand 5 binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CCR2a Polyclonal Antibody

CCR2a Antibody (16153-1-AP) in Flow

Product Details

16153-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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