Proteintech

CCR5 Polyclonal Antibody

CCR5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CCR5 Antibody (17476-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 17476-1-AP ( CCR5 antibody) at dilution of 1:800 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

17476-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400-1:1,600

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CCR5 Fusion Protein Ag11493 (257-352 aa encoded by BC038398)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LNTFQEFFG LNNCSSSNRL DQAMQVTETL GMTHCCINPI IYAFVGEKFR NYLLVFFQKH IAKRFCKCCS IFQQEAPERA SSVYTRSTGE QEISVGL (257-352 aa encoded by BC038398 )

Target Information

Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression.

Journal for immunotherapy of cancer

Xu J,Shi Q,Lou J,Wang B,Wang W,Niu J,Guo L,Chen C,Yu Y,Huang Y,Guo W,Lan J,Zhu Y,Ren T,Tang X

Sat Apr 01 00:00:00 EDT 2023

Magnify is a universal molecular anchoring strategy for expansion microscopy.

Nature biotechnology

Klimas A,Gallagher BR,Wijesekara P,Fekir S,DiBernardo EF,Cheng Z,Stolz DB,Cambi F,Watkins SC,Brody SL,Horani A,Barth AL,Moore CI,Ren X,Zhao Y

Thu Jun 01 00:00:00 EDT 2023

Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis.

Cell death & disease

Xu H,Zhao J,Li J,Zhu Z,Cui Z,Liu R,Lu R,Yao Z,Xu Q

Fri May 20 00:00:00 EDT 2022

Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.

Nature immunology

Huang D,Chen X,Zeng X,Lao L,Li J,Xing Y,Lu Y,Ouyang Q,Chen J,Yang L,Su F,Yao H,Liu Q,Su S,Song E

Thu Jul 01 00:00:00 EDT 2021

Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.

Nature immunology

Huang D,Chen X,Zeng X,Lao L,Li J,Xing Y,Lu Y,Ouyang Q,Chen J,Yang L,Su F,Yao H,Liu Q,Su S,Song E

Thu Jul 01 00:00:00 EDT 2021

PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats.

Scientific reports

Li J,Peng C,Lai D,Fang Y,Luo D,Zhou Z,Li C,Lai X

Wed May 26 00:00:00 EDT 2021

CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4⁺ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4⁺ T cell enrichment in humanized mice.

Retrovirology

Xiao Q,Chen S,Wang Q,Liu Z,Liu S,Deng H,Hou W,Wu D,Xiong Y,Li J,Guo D

Tue Jun 11 00:00:00 EDT 2019

Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis.

Journal of neurovirology

Delery E,Bohannon DG,Irons DL,Allers C,Sugimoto C,Cai Y,Merino KM,Amedee AM,Veazey RS,MacLean A,Kuroda MJ,Kim WK

Thu Aug 01 00:00:00 EDT 2019

Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys¹⁹⁷ and by transmembrane protein aptamers that target it for lysosomal degradation.

The Journal of biological chemistry

Petti LM,Marlatt SA,Luo Y,Scheideman EH,Shelar A,DiMaio D

Fri Jun 08 00:00:00 EDT 2018

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats.

Progress in neuro-psychopharmacology & biological psychiatry

Kwiatkowski K,Piotrowska A,Rojewska E,Makuch W,Jurga A,Slusarczyk J,Trojan E,Basta-Kaim A,Mika J

Mon Jan 04 00:00:00 EST 2016

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats.

Progress in neuro-psychopharmacology & biological psychiatry

Kwiatkowski K,Piotrowska A,Rojewska E,Makuch W,Jurga A,Slusarczyk J,Trojan E,Basta-Kaim A,Mika J

Mon Jan 04 00:00:00 EST 2016

Bioinformatics

Protein Aliases: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; CHEMR13; HIV-1 fusion coreceptor

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Gene Aliases: CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; CKR-5; CKR5; CMKBR5; IDDM22

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UniProt ID: (Human) P51681

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Entrez Gene ID: (Human) 1234

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Function(s)

virus receptor activity actin binding phosphatidylinositol phospholipase C activity chemokine receptor activity protein binding coreceptor activity C-C chemokine receptor activity C-C chemokine binding chemokine (C-C motif) ligand 5 binding

Process(es)

MAPK cascade dendritic cell chemotaxis calcium ion transport chemotaxis inflammatory response immune response cellular defense response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling release of sequestered calcium ion into cytosol by sarcoplasmic reticulum fusion of virus membrane with host plasma membrane calcium-mediated signaling signaling entry into host cell chemokine-mediated signaling pathway response to cholesterol cellular response to lipopolysaccharide

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CCR5 Polyclonal Antibody

CCR5 Antibody (17476-1-AP) in IHC (P)

Product Details

17476-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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