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Product Details
PA5-78950
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of mouse CCR5 (181-199aa SPHFPHTQYHFWKSFQTLK).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746066
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CD195; CD195 antigen; chemokine (C-C) receptor 5; MIP-1 alpha receptor
Gene Aliases: AM4-7; Ccr5; CD195; Cmkbr5
UniProt ID: (Mouse) P51682
Entrez Gene ID: (Mouse) 12774
calcium ion transport
chemotaxis
defense response
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
positive regulation of gene expression
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
calcium-mediated signaling
positive regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of axon extension
positive regulation of fever generation
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of neuron differentiation
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
positive regulation of apoptotic process by virus
chemokine-mediated signaling pathway
response to cholesterol
neuron death
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of macrophage apoptotic process
negative regulation of neural precursor cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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