Immunogen sequence: MSPGSGVKSE YMKRYQEPRW EEYGPCYREL LHYRLGRRLL EQAHAPWLWD DWGPAGSSED SASSESSGAG GPAPRCAPPS PPPPVEPATQ EEAERRARGA PEEQDAEAGD AEAEDAEDAA LPALPVKDVE DKPEQQTRTR ETDKSPTSTE PRQQPSALFA RGNRKAVKSP QRSSSKIKEN KHPFALYGWG EKQTDTGSQK THNVCASAPV HEIHESALRA KNRRQVEKRK LVAQRQRAHS VDVEKNRKMK ASSSENPWMT EYMRCYSARA
Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: centriole and spindle-associated protein; Centriole, cilia and spindle-associated protein
Gene Aliases: 1700054N08Rik; AI853424; C1orf96; CCSAP; CSAP; RGD1563235
UniProt ID: (Human) Q6IQ19, (Mouse) Q8QZT2
Entrez Gene ID: (Human) 126731, (Rat) 307926, (Mouse) 73420
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