Proteintech

CCT4 Polyclonal Antibody

CCT4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

CCT4 Antibody (21524-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue slide using (Product # 21524-1-AP) CCT4 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

21524-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CCT4 Fusion Protein Ag16128 (108-407 aa encoded by BC106934)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SVVIIAGSL LDSCTKLLQK GIHPTIISES FQKALEKGIE ILTDMSRPVE LSDRETLLNS ATTSLNSKVV SQYSSLLSPM SVNAVMKVID PATATSVDLR DIKIVKKLGG TIDDCELVEG LVLTQKVSNS GITRVEKAKI GLIQFCLSAP KTDMDNQIVV SDYAQMDRVL REERAYILNL VKQIKKTGCN VLLIQKSILR DALSDLALHF LNKMKIMVIK DIEREDIEFI CKTIGTKPVA HIDQFTADML GSAELAEEVN LNGSGKLLKI TGCASPGKTV TIVVRGSNKL VIEEAERSIH D (108-407 aa encoded by BC106934)

Target Information

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.

Science translational medicine

Lima TI,Laurila PP,Wohlwend M,Morel JD,Goeminne LJE,Li H,Romani M,Li X,Oh CM,Park D,Rodríguez-López S,Ivanisevic J,Gallart-Ayala H,Crisol B,Delort F,Batonnet-Pichon S,Silveira LR,Sankabattula Pavani Veera Venkata L,Padala AK,Jain S,Auwerx J

Wed May 17 00:00:00 EDT 2023

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.

Cell

Ma X,Lu C,Chen Y,Li S,Ma N,Tao X,Li Y,Wang J,Zhou M,Yan YB,Li P,Heydari K,Deng H,Zhang M,Yi C,Ge L

Thu Apr 14 00:00:00 EDT 2022

CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.

Molecular carcinogenesis

Fang J,Ma Y,Li Y,Li J,Zhang X,Han X,Ma S,Guan F

Tue Nov 01 00:00:00 EDT 2022

hsa_circ_0001018 promotes papillary thyroid cancer by facilitating cell survival, invasion, G₁/S cell cycle progression, and repressing cell apoptosis via crosstalk with miR-338-3p and SOX4.

Molecular therapy. Nucleic acids

Luo Q,Guo F,Fu Q,Sui G

Fri Jun 04 00:00:00 EDT 2021

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.

The Journal of cell biology

Zhang YC,Bai YF,Yuan JF,Shen XL,Xu YL,Jian XX,Li S,Song ZQ,Hu HB,Li PY,Tu HQ,Han QY,Wang N,Li AL,Zhang XM,Wu M,Zhou T,Li HY

Mon Feb 01 00:00:00 EST 2021

Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.

Pathogens and disease

Hirai K,Maeda H,Omori K,Yamamoto T,Kokeguchi S,Takashiba S

Sat Jun 01 00:00:00 EDT 2013

Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.

Pathogens and disease

Hirai K,Maeda H,Omori K,Yamamoto T,Kokeguchi S,Takashiba S

Sat Jun 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: A45; CCT-delta; Chaperonin containing T-complex polypeptide 1 subunit 4; chaperonin containing t-complex polypeptide 1, delta subunit; chaperonin containing TCP1, subunit 4 (delta); chaperonin subunit 4 (delta); Stimulator of TAR RNA-binding; T complex protein 1, delta; T-complex protein 1 subunit delta; TCP-1 delta; TCP-1-delta

View more View less

Gene Aliases: 2610204B21Rik; A45; C78323; CCT-DELTA; CCT4; CCTD; SRB

View more View less

UniProt ID: (Human) F5H5W3, (Mouse) P80315, (Rat) Q7TPB1

View more View less

Entrez Gene ID: (Human) 10575, (Mouse) 12464, (Rat) 29374

View more View less

Function(s)

protein binding ATP binding poly(A) RNA binding unfolded protein binding nucleotide binding chaperonin

Process(es)

protein folding binding of sperm to zona pellucida positive regulation of telomere maintenance via telomerase protein stabilization positive regulation of telomerase activity scaRNA localization to Cajal body toxin transport positive regulation of establishment of protein localization to telomere positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body chaperone mediated protein folding requiring cofactor

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

CCT4 Polyclonal Antibody

CCT4 Antibody (21524-1-AP) in IHC (P)

Product Details

21524-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!