Proteintech

CCT5 Polyclonal Antibody

CCT5 Antibody in Immunocytochemistry (ICC/IF)

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CCT5 Antibody (11603-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using CCT5 antibody 11603-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

CCT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CCT5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11603-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CCT5 Fusion Protein Ag2146 (242-541 aa encoded by BC035499)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KVEDAKIAI LTCPFEPPKP KTKHKLDVTS VEDYKALQKY EKEKFEEMIQ QIKETGANLA ICQWGFDDEA NHLLLQNNLP AVRWVGGPEI ELIAIATGGR IVPRFSELTA EKLGFAGLVQ EISFGTTKDK MLVIEQCKNS RAVTIFIRGG NKMIIEEAKR SLHDALCVIR NLIRDNRVVY GGGAAEISCA LAVSQEADKC PTLEQYAMRA FADALEVIPM ALSENSGMNP IQTMTEVRAR QVKEMNPALG IDCLHKGTND MKQQHVIETL IGKKQQISLA TQMVRMILKI DDIRKPGESE E (242-541 aa encoded by BC035499)

Target Information

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.

Cell

Ma X,Lu C,Chen Y,Li S,Ma N,Tao X,Li Y,Wang J,Zhou M,Yan YB,Li P,Heydari K,Deng H,Zhang M,Yi C,Ge L

Thu Apr 14 00:00:00 EDT 2022

Chaperonin-Containing TCP1 Subunit 5 Protects Against the Effect of Mer Receptor Tyrosine Kinase Knockdown in Retinal Pigment Epithelial Cells by Interacting With Filamentous Actin and Activating the LIM-Kinase 1/Cofilin Pathway.

Frontiers in medicine

Feng L,Li H,Du Y,Zhang T,Zhu Y,Li Z,Zhao L,Wang X,Wang G,Zhou L,Jiang Z,Liu Z,Ou Z,Wen Y,Zhuo Y

Tue May 03 00:00:00 EDT 2022

Frontiers in medicine

Feng L,Li H,Du Y,Zhang T,Zhu Y,Li Z,Zhao L,Wang X,Wang G,Zhou L,Jiang Z,Liu Z,Ou Z,Wen Y,Zhuo Y

Tue May 03 00:00:00 EDT 2022

Frontiers in medicine

Feng L,Li H,Du Y,Zhang T,Zhu Y,Li Z,Zhao L,Wang X,Wang G,Zhou L,Jiang Z,Liu Z,Ou Z,Wen Y,Zhuo Y

Tue May 03 00:00:00 EDT 2022

CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion.

Biochemical and biophysical research communications

Meng Y,Yang L,Wei X,Luo H,Hu Y,Tao X,He J,Zheng X,Xu Q,Luo K,Yu G,Luo Q

Fri Aug 27 00:00:00 EDT 2021

CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion.

Biochemical and biophysical research communications

Meng Y,Yang L,Wei X,Luo H,Hu Y,Tao X,He J,Zheng X,Xu Q,Luo K,Yu G,Luo Q

Fri Aug 27 00:00:00 EDT 2021

CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion.

Biochemical and biophysical research communications

Meng Y,Yang L,Wei X,Luo H,Hu Y,Tao X,He J,Zheng X,Xu Q,Luo K,Yu G,Luo Q

Fri Aug 27 00:00:00 EDT 2021

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.

The Journal of cell biology

Zhang YC,Bai YF,Yuan JF,Shen XL,Xu YL,Jian XX,Li S,Song ZQ,Hu HB,Li PY,Tu HQ,Han QY,Wang N,Li AL,Zhang XM,Wu M,Zhou T,Li HY

Mon Feb 01 00:00:00 EST 2021

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.

The Journal of cell biology

Zhang YC,Bai YF,Yuan JF,Shen XL,Xu YL,Jian XX,Li S,Song ZQ,Hu HB,Li PY,Tu HQ,Han QY,Wang N,Li AL,Zhang XM,Wu M,Zhou T,Li HY

Mon Feb 01 00:00:00 EST 2021

Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.

Frontiers in microbiology

Zhang X,Lin X,Qin C,Huang K,Sun X,Zhao L,Jin M

Fri Nov 13 00:00:00 EST 2020

Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.

Frontiers in microbiology

Zhang X,Lin X,Qin C,Huang K,Sun X,Zhao L,Jin M

Fri Nov 13 00:00:00 EST 2020

DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Nature genetics

Tarkar A,Loges NT,Slagle CE,Francis R,Dougherty GW,Tamayo JV,Shook B,Cantino M,Schwartz D,Jahnke C,Olbrich H,Werner C,Raidt J,Pennekamp P,Abouhamed M,Hjeij R,Köhler G,Griese M,Li Y,Lemke K,Klena N,Liu X,Gabriel G,Tobita K,Jaspers M,Morgan LC,Shapiro AJ,Letteboer SJ,Mans DA,Carson JL,Leigh MW,Wolf WE,Chen S,Lucas JS,Onoufriadis A,Plagnol V,Schmidts M,Boldt K,Roepman R,Zariwala MA,Lo CW,Mitchison HM,Knowles MR,Burdine RD,Loturco JJ,Omran H

Sun Sep 01 00:00:00 EDT 2013

DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Nature genetics

Sun Sep 01 00:00:00 EDT 2013

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

Proceedings of the National Academy of Sciences of the United States of America

Seo S,Baye LM,Schulz NP,Beck JS,Zhang Q,Slusarski DC,Sheffield VC

Tue Jan 26 00:00:00 EST 2010

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

Proceedings of the National Academy of Sciences of the United States of America

Seo S,Baye LM,Schulz NP,Beck JS,Zhang Q,Slusarski DC,Sheffield VC

Tue Jan 26 00:00:00 EST 2010

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

Proceedings of the National Academy of Sciences of the United States of America

Seo S,Baye LM,Schulz NP,Beck JS,Zhang Q,Slusarski DC,Sheffield VC

Tue Jan 26 00:00:00 EST 2010

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

Proceedings of the National Academy of Sciences of the United States of America

Seo S,Baye LM,Schulz NP,Beck JS,Zhang Q,Slusarski DC,Sheffield VC

Tue Jan 26 00:00:00 EST 2010

Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT.

Molecular oral microbiology

Yamabe K,Maeda H,Kokeguchi S,Soga Y,Meguro M,Naruishi K,Asakawa S,Takashiba S

Thu Apr 01 00:00:00 EDT 2010

Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT.

Molecular oral microbiology

Yamabe K,Maeda H,Kokeguchi S,Soga Y,Meguro M,Naruishi K,Asakawa S,Takashiba S

Thu Apr 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: CCT-epsilon; Chaperonin containing T-complex polypeptide 1 subunit 5; chaperonin containing TCP1, subunit 5 (epsilon); chaperonin subunit 5 (epsilon); epididymis secretory protein Li 69; T-complex protein 1 subunit epsilon; TCP-1-epsilon

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Gene Aliases: CCT-epsilon; CCT5; CCTE; HEL-S-69; KIAA0098; mKIAA0098; PNAS-102; TCP-1-epsilon; TCPE

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UniProt ID: (Human) P48643, (Mouse) P80316, (Rat) Q68FQ0

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Entrez Gene ID: (Human) 22948, (Mouse) 12465, (Rat) 294864

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Function(s)

protein binding ATP binding G-protein beta-subunit binding beta-tubulin binding unfolded protein binding nucleotide binding chaperonin

Process(es)

protein folding binding of sperm to zona pellucida response to virus positive regulation of telomere maintenance via telomerase protein stabilization toxin transport positive regulation of establishment of protein localization to telomere positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CCT5 Polyclonal Antibody

CCT5 Antibody (11603-1-AP) in ICC/IF

Product Details

11603-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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