Product References
P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer.
Cancer immunology research
Ren J,Han X,Lohner H,Hoyle RG,Li J,Liang S,Wang H
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 12-1071-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy.
Cell reports
Chang Y,Syahirah R,Wang X,Jin G,Torregrosa-Allen S,Elzey BD,Hummel SN,Wang T,Li C,Lian X,Deng Q,Broxmeyer HE,Bao X
12-1071-82 was used in Flow Cytometry to establish a robust platform for massive production of CAR neutrophils, paving the way to myeloid cell-based therapeutic strategies that would boost current cancer-treatment approaches.
Tue Jul 19 00:00:00 EDT 2022
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.
Nature communications
Wang Q,Hernández-Ochoa EO,Viswanathan MC,Blum ID,Do DC,Granger JM,Murphy KR,Wei AC,Aja S,Liu N,Antonescu CM,Florea LD,Talbot CC,Mohr D,Wagner KR,Regot S,Lovering RM,Gao P,Bianchet MA,Wu MN,Cammarato A,Schneider MF,Bever GS,Anderson ME
12-1071-82 was used in Flow Cytometry to examine CaMKII and find that its activation by reactive oxygen species (ROS) was acquired more than half-a-billion years ago along the vertebrate stem lineage.
Wed May 26 00:00:00 EDT 2021
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
12-1071 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
12-1071 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor.
BMC gastroenterology
Salhab A,Amer J,Yinying L,Safadi R
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 12-1071-82) in Flow Cytometry
Fri Apr 10 00:00:00 EDT 2020
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.
The Journal of clinical investigation
Randzavola LO,Strege K,Juzans M,Asano Y,Stinchcombe JC,Gawden-Bone CM,Seaman MN,Kuijpers TW,Griffiths GM
12-1071-82 was used in Flow cytometry/Cell sorting to show that loss of actin-related protein complex 1B led to loss of CD8 cytotoxic T lymphocytes cytotoxicity, with the defect arising at 2 different levels.
Mon Dec 02 00:00:00 EST 2019
T cell cytolytic capacity is independent of initial stimulation strength.
Nature immunology
Richard AC,Lun ATL,Lau WWY,Göttgens B,Marioni JC,Griffiths GM
12-1071 was used in Flow cytometry/Cell sorting to study how ligand potency affects the activation of CD8+ T cells in vitro.
Wed Aug 01 00:00:00 EDT 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Wed Mar 28 00:00:00 EDT 2018
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
12-1071-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells.
Leukemia
Cheadle EJ,Lipowska-Bhalla G,Dovedi SJ,Fagnano E,Klein C,Honeychurch J,Illidge TM
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 12-1071-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 12-1071-82) in Flow Cytometry
Wed Sep 07 00:00:00 EDT 2016
A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy.
PLoS pathogens
Pereira IR,Vilar-Pereira G,Marques V,da Silva AA,Caetano B,Moreira OC,Machado AV,Bruna-Romero O,Rodrigues MM,Gazzinelli RT,Lannes-Vieira J
12-1071 was used in Flow cytometry/Cell sorting to assess the use of vaccination as an alternative, effective treatment for chronic chagasic cardiomyopathy.
Thu Jan 01 00:00:00 EST 2015
CD8+ T Cells Can Mediate Short-Term Protection against Heterotypic Dengue Virus Reinfection in Mice.
Journal of virology
Zellweger RM,Tang WW,Eddy WE,King K,Sanchez MC,Shresta S
12-1071 was used in Flow cytometry/Cell sorting to investigate short-term protection against heterotypic Dengue virus reinfection in mice mediated by CD8+ T Cells.
Mon Jun 01 00:00:00 EDT 2015
Tailoring a Combination Preerythrocytic Malaria Vaccine.
Infection and immunity
Bauza K,Atcheson E,Malinauskas T,Blagborough AM,Reyes-Sandoval A
12-1071 was used in Flow cytometry/Cell sorting to demonstrate that a combination of circumsporozoite protein and thrombospondin-related adhesive protein subunit vaccines could enhance protection against malaria.
Mon Dec 14 00:00:00 EST 2015
Pentoxifylline reverses chronic experimental Chagasic cardiomyopathy in association with repositioning of abnormal CD8+ T-cell response.
PLoS neglected tropical diseases
Pereira IR,Vilar-Pereira G,Moreira OC,Ramos IP,Gibaldi D,Britto C,Moraes MO,Lannes-Vieira J
12-1071 was used in Flow cytometry/Cell sorting to evaluate a novel candidate to treat the non-beneficial immune deregulation associated with chronic Chagas' heart disease.
Sun Mar 01 00:00:00 EST 2015
Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice.
PloS one
Longley RJ,Halbroth BR,Ewer KJ,Hill AV,Spencer AJ
12-1071-82 was used in Flow cytometry to investigate the cellular immune response in mice to three viral vectored vaccines expressing Plasmodium falciparum antigens PfUIS3, PfLSA1 and PfLSAP2.
Sun Jun 26 00:00:00 EDT 2016
Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages.
PloS one
Moreira-Souza AC,Marinho Y,Correa G,Santoro GF,Coutinho CM,Vommaro RC,Coutinho-Silva R
12-1071 was used in Immunocytochemistry to suggest that the activity of P2Y host cell receptors controls Toxoplasma gondii infection in macrophages.
Mon Apr 25 00:00:00 EDT 2016
Predominant role of interferon-γ in the host protective effect of CD8(+) T cells against Neospora caninum infection.
Scientific reports
Correia A,Ferreirinha P,Botelho S,Belinha A,Leitão C,Caramalho Í,Teixeira L,González-Fernandéz Á,Appelberg R,Vilanova M
12-1071 was used in Flow cytometry/Cell sorting to investigate the role of CD8(+) T cells in the course of Neospora caninum infection.
Fri Oct 09 00:00:00 EDT 2015
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
The Journal of experimental medicine
Fan X,Quezada SA,Sepulveda MA,Sharma P,Allison JP
12-1071 was used in Flow cytometry/Cell sorting to investigate the role of the ICOS pathway in increasing the efficiency of the CTLA-4 blockade in cancer immunotherapy.
Mon Apr 07 00:00:00 EDT 2014
CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice.
Journal of immunology (Baltimore, Md. : 1950)
Zellweger RM,Eddy WE,Tang WW,Miller R,Shresta S
12-1071 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cell responses influence the outcome of antibody-mediated severe dengue disease.
Wed Oct 15 00:00:00 EDT 2014
Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages.
International journal of inflammation
Weber K,Schilling JD
12-1071 was used in Flow cytometry/Cell sorting to reveal dramatic baseline differences in the lysosome morphology and function between macrophage populations.
Wed Jan 14 00:00:00 EST 2015
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 12-1071-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2015
CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy.
PLoS pathogens
Silverio JC,Pereira IR,Cipitelli Mda C,Vinagre NF,Rodrigues MM,Gazzinelli RT,Lannes-Vieira J
12-1071 was used in Flow cytometry/Cell sorting to suggest that CD8+ IFNc+ cells are beneficial, whereas CD8+ Pfn+ cells are detrimental in Trypanosoma cruzi-elicited heart injury.
Mon Aug 20 00:00:00 EDT 2012
Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation.
European journal of immunology
Lui-Roberts WW,Stinchcombe JC,Ritter AT,Akhmanova A,Karakesisoglou I,Griffiths GM
12-1071 was used in Flow cytometry/Cell sorting to determine whether the centrosome must be dissociated from the nuclear membrane during target cell killing by cytotoxic T lymphocytes.
Wed Aug 01 00:00:00 EDT 2012
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
The Journal of experimental medicine
Thompson ED,Enriquez HL,Fu YX,Engelhard VH
12-1071 was used in Flow cytometry/Cell sorting to study the ways in which tumour masses support naive T cell functions.
Mon Aug 02 00:00:00 EDT 2010
Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection.
Journal of virology
Guo H,Topham DJ
12-1071 was used in Flow cytometry/Cell sorting to test whether interleukin-22 (IL-22) is protective during influenza virus infection, showing that IL-22 plays a marginal role for protection, with a differential requirement of this cytokine for bacterial and viral infections.
Sun Aug 01 00:00:00 EDT 2010
Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice.
The Journal of clinical investigation
Zhang Z,Clarke TB,Weiser JN
12-1071-82 was used in Immunocytochemistry to demonstrate that monocytes/macrophages and neutrophils recruited to the upper airway lumen are key effectors in clearing primary and secondary Streptococcal pneumoniae colonisation, respectively.
Wed Jul 01 00:00:00 EDT 2009
Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras.
Blood
Durkin ET,Jones KA,Rajesh D,Shaaban AF
12-1071 was used in Flow cytometry/Cell sorting to study the effect chimerism level on engraftment and host natural killer (NK)-cell education in a murine model of in utero hematopoietic cell transplantation (IUHCT), showing that early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras.
Mon Dec 15 00:00:00 EST 2008