Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
BS-11127R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CD11b.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. CD11b is also a receptor for fibrogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% thymocytes and is commonly used as a microgial marker in nervous tissue. CD11c encodes the integrin alpha X chain protein. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Mutations affecting the CD11b/c gene lead to systemic lupus erythematosus 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: antigen CD11b (p170); CD11 antigen-like family member B; CD11 antigen-like family member C; CD11b; CD11B (p170); CD11bc; CD11c; CD11C (p150) alpha polypeptide; cell surface glycoprotein MAC-1 alpha subunit; Cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component 3 receptor 4 subunit; complement component receptor 3 alpha-a; complement receptor 4; complement receptor type 3; CR-3 alpha chain; CR3A; Integrin alpha M; integrin alpha X; Integrin alpha-M; Integrin alpha-X; integrin aX; integrin, alpha M (complement component 3 receptor 3 subunit); integrin, alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); Leu M5; leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; Leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; MAC-1; Mac-1 alpha; MAC1A; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; myeloid membrane antigen, alpha subunit; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; OX-42; OX42; p150 95 integrin alpha chain; SLEB6
Gene Aliases: AI449405; CD11B; CD11b/CD18; CD11C; CR3; CR3A; Cr4; F730045J24Rik; ITGAM; ITGAX; Ly-40; MAC-1; Mac-1a; MAC1; MAC1A; MO1A; N418; RGD1561123; SLEB6
UniProt ID: (Human) P11215, (Human) P20702, (Mouse) Q9QXH4
Entrez Gene ID: (Human) 3684, (Human) 3687, (Mouse) 16409, (Rat) 25021, (Mouse) 16411, (Rat) 499271
cell adhesion
integrin-mediated signaling pathway
ectodermal cell differentiation
extracellular matrix organization
toll-like receptor 4 signaling pathway
leukocyte migration
organ morphogenesis
heterotypic cell-cell adhesion
positive regulation of protein targeting to mitochondrion
leukocyte migration involved in inflammatory response
leukocyte cell-cell adhesion
microglia development
single organismal cell-cell adhesion
neutrophil chemotaxis
cellular extravasation
activated T cell proliferation
defense response to virus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support