Invitrogen

CD11c Monoclonal Antibody (N418), PE-Texas Red

FIGURE: 1 / 1

CD11c Antibody (MCD11C17) in Flow

Communications biology 2021 - Fig. 6 LXRalpha S196A ATMs are less inflammatory. Immune cells in pWAT from LXRalpha WT and S196A were analyzed by flow cytometry: A adipose tissue macrophages (ATM), B FBC and FB populations, C FBC (F4/80 + , CD11b + , CD11c + ) as a percentage of CD45 + F4/80 + cells, and D FB (F4/80 + , CD11b + , CD11c - ) as a percentage of CD45 + F4/80 + cells, and E ratio FBC/FB. Data are expressed as mean +- SD ( n =... View More

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Product Details

MCD11C17

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-dependent

View 7 publications 7 publications

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Armenian hamster / IgG

Class

Monoclonal

Type

Antibody

Clone

N418

Immunogen

Mouse CD11c.

Conjugate

PE-Texas Red PE-Texas Red PE-Texas Red

Excitation/Emission Max

567/615 nm View spectra

Form

Liquid

Purification

purified

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10373971

Target Information

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice.

Communications biology

Voisin M,Shrestha E,Rollet C,Nikain CA,Josefs T,Mahé M,Barrett TJ,Chang HR,Ruoff R,Schneider JA,Garabedian ML,Zoumadakis C,Yun C,Badwan B,Brown EJ,Mar AC,Schneider RJ,Goldberg IJ,Pineda-Torra I,Fisher EA,Garabedian MJ

Published figure using CD11c monoclonal antibody (Product # MCD11c17) in Flow Cytometry

Fri Mar 26 00:00:00 EDT 2021

Assessing Lupus-Like Disease in Murine Model Systems.

Current protocols

Lee HY,Celhar T,Fairhurst AM

MCD11c17 was used in Flow Cytometry to evaluate the underlying immunological features of the disease, as a more sensitive strategy to understand the disease itself and the mechanisms of potential novel therapeutics.

Mon Nov 01 00:00:00 EDT 2021

Interleukin 21 collaborates with interferon-γ for the optimal expression of interferon-stimulated genes and enhances protection against enteric microbial infection.

PLoS pathogens

Solaymani-Mohammadi S,Berzofsky JA

MCD11c17 was used in Flow cytometry/Cell sorting to understand the roles played by the IL-21/IL-21R signalling axis in the context of enteric microbial infections.

Fri Feb 01 00:00:00 EST 2019

A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner.

Cancer discovery

Donohoe DR,Holley D,Collins LB,Montgomery SA,Whitmore AC,Hillhouse A,Curry KP,Renner SW,Greenwalt A,Ryan EP,Godfrey V,Heise MT,Threadgill DS,Han A,Swenberg JA,Threadgill DW,Bultman SJ

MCD11c17 was used in Flow cytometry/Cell sorting to assess whether dietary fiber is protective in colorectal cancer.

Mon Dec 01 00:00:00 EST 2014

Early host cell targets of Yersinia pestis during primary pneumonic plague.

PLoS pathogens

Pechous RD,Sivaraman V,Price PA,Stasulli NM,Goldman WE

MCD11c17 was used in flow cytometry to determine when in infection Yersinia pestis infects macrophages and neutrophils

Mon May 26 00:00:00 EDT 2014

Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets.

Immunology

Valentino MD,Maben ZJ,Hensley LL,Woolard MD,Kawula TH,Frelinger JA,Frelinger JG

MCD11C17 was used in flow cytometry to identify T-cell epitopes of Francisella tularensis.

Tue Mar 01 00:00:00 EST 2011

Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells.

Infection and immunity

Woolard MD,Hensley LL,Kawula TH,Frelinger JA

MCD11c17 was used in flow cytometry to investigate how the route of inoculation with Francisella tularensis influences the primary acute adaptive immune response

Sun Jun 01 00:00:00 EDT 2008

Bioinformatics

Protein Aliases: CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement receptor 4; Integrin alpha-X; integrin aX; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95

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Gene Aliases: AI449405; Cd11c; Cr4; Itgax; N418

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UniProt ID: (Mouse) Q9QXH4

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Entrez Gene ID: (Mouse) 16411

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Function(s)

metal ion binding integrin

Process(es)

cell adhesion integrin-mediated signaling pathway heterotypic cell-cell adhesion activated T cell proliferation defense response to virus positive regulation of protein targeting to mitochondrion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD11c Monoclonal Antibody (N418), PE-Texas Red

CD11c Antibody (MCD11C17) in Flow

Product Details

MCD11C17

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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