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CD137 (4-1BB) Antibody (MA5-28560) in Flow
Separation of cells stained using anti-humam CD137 (4B4-1) purified Monoclonal antibody (Product # MA5-28560), concentration in sample 4 µg/mL (GAM APC, red-filled) from cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining) of human PHA stimulated peripheral blood mononuclear cell suspension.
Product Details
MA5-28560
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Baboon,
Chimpanzee,
Cynomolgus monkey,
Human,
Non-human primate,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4B4-1
Immunogen
Recombinant human CD137 ectodomain
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745519
Product Specific Information
This antibody recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137; CD137 antigen; CDw137; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
Gene Aliases: 4-1BB; CD137; CDw137; EGK_00183; ILA; TNFRSF9
UniProt ID: (Human) Q07011
Entrez Gene ID: (Cynomolgus monkey) 102127961, (Human) 3604, (Rhesus monkey) 708281
apoptotic process
inflammatory response
immune response
multicellular organism development
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of apoptotic process
protein homotrimerization
negative regulation of interleukin-10 secretion
negative regulation of interleukin-12 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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