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Invitrogen
CD137 Monoclonal Antibody (4B4-1), Alexa Fluor™ 647
Product Details
A51019
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4B4-1
Immunogen
Recombinant human CD137 ectodomain
Conjugate
Excitation/Emission Max
650/671 nm
View spectra
Form
Liquid
Concentration
0.04 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.0325% sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Ambient
RRID
AB_2633303
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137; CD137 antigen; CDw137; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
Gene Aliases: 4-1BB; CD137; CDw137; ILA; TNFRSF9
UniProt ID: (Human) Q07011
Entrez Gene ID: (Human) 3604
apoptotic process
inflammatory response
immune response
multicellular organism development
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of apoptotic process
protein homotrimerization
negative regulation of interleukin-10 secretion
negative regulation of interleukin-12 secretion
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