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Invitrogen
CD137 Chimeric Recombinant Rabbit Monoclonal Antibody (LOB12.3)
FIGURE: 1 / 2
CD137 Chimeric Antibody (MA5-48147) in ELISA
ELISA analysis of CD137 chimeric monoclonal antibody (Product # MA5-48147) was performed by coating plate with Mouse IgE-Fc (blue line), Dog IgE-Fc (orange line) and Mouse 4-1BB Fc-Fusion Protein (grey line) at a concentration of 2.5 µg/mL. A 3-fold serial dilution from 3,000 to 0.0169 ng/mL of the antibody was done. For signal detection, a 1:4,000 dilution of a HRP-conjugated anti-rabbit IgG antibody was used.
Product Details
MA5-48147
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
LOB12.3
Immunogen
This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074590
Product Specific Information
Specificity: This antibody binds to mouse 4-1BB (CD137).
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137; CD137 antigen; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T-cell antigen 4-1BB; Tumor necrosis factor receptor superfamily member 9
Gene Aliases: 4-1BB; A930040I11Rik; AA408498; AI325004; Cd137; CDw137; ILA; Ly63; Tnfrsf9
UniProt ID: (Mouse) P20334
Entrez Gene ID: (Mouse) 21942
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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