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Invitrogen
CD137 Ligand (4-1BB Ligand) Recombinant Rabbit Monoclonal Antibody (BLR148J)
FIGURE: 1 / 1
CD137 Ligand (4-1BB Ligand) Antibody (MA5-44483) in WB
Western Blot of CD137 Ligand (4-1BB Ligand) in whole cell lysate (25 µg) from HEK293T, Jurkat, Raji, NCI-H460, and HeLa cells. Samples were treated with NETN lysis buffer, incubated with CD137 Ligand (4-1BB Ligand) monoclonal antibody (Product # MA5-44484) at a dilution of 1:1000, followed by HRP-conjugated goat anti-rabbit IgG (exposure time of 3 minutes). Lower Panel: Rabbit anti-COPB2.
Product Details
MA5-44483
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR148J
Immunogen
Recombinant protein representing the extracellular domain of Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9, aka 4-1BBL, CD137L; residues 71-254).
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
purified
Storage buffer
PBS, pH 6.8-7.4
Contains
0.09% sodium azide
Storage conditions
2-8°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2926613
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4 1 BB Ligand; 4 1 BBL; 4-1BB ligand; 4-1BBL; 41BB Ligand; 41BBL; CD 137 Ligand; CD 137L; CD137 Ligand; CDw137L; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; TNFRSF9; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; Tumor necrosis factor ligand superfamily member 9
Gene Aliases: 4-1BB-L; CD137L; TNFSF9; TNLG5A
UniProt ID: (Human) P41273
Entrez Gene ID: (Human) 8744
apoptotic process
immune response
signal transduction
cell-cell signaling
cell proliferation
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of activated T cell proliferation
myeloid dendritic cell differentiation
positive regulation of cytotoxic T cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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