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CD138 Antibody (MA5-44041) in IHC (P)
Immunohistochemical analysis of CD138 (Syndecan-1) was performed using formalin-fixed paraffin-embedded human tonsil tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15... View More
Product Details
MA5-44041
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
MI15
Immunogen
A mixture of U266 and XG-1 human myeloma cell lines
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912973
Product Specific Information
This antibody recognizes an extracellular epitope of CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.
Target Information
CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 138; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; sCD138; soluble CD138; SYND1; syndecan proteoglycan 1; Syndecan-1; Syndecan1
Gene Aliases: CD138; SDC; SDC1; SYND1; syndecan
UniProt ID: (Human) P18827
Entrez Gene ID: (Human) 6382
retinoid metabolic process
ureteric bud development
glycosaminoglycan biosynthetic process
glycosaminoglycan catabolic process
inflammatory response
response to toxic substance
cell migration
glycosaminoglycan metabolic process
wound healing
lipoprotein metabolic process
odontogenesis
response to hydrogen peroxide
myoblast development
response to glucocorticoid
response to cAMP
response to calcium ion
striated muscle cell development
Sertoli cell development
canonical Wnt signaling pathway
positive regulation of exosomal secretion
positive regulation of extracellular exosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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