Proteintech

CD138/Syndecan-1 Polyclonal Antibody

CD138/Syndecan-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD138/Syndecan-1 Antibody (10593-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 10593-1-AP (CD138/Syndecan-1 antibody) at dilution of 1:1600 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CD138/Syndecan-1 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

10593-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:800-1:3200

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

Assay-dependent

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD138/Syndecan-1 Fusion Protein Ag0823 (1-310 aa encoded by BC008765)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRRAALWLW LCALALSLQP ALPQIVATNL PPEDQDGSGD DSDNFSGSGA GALQDITLSQ QTPSTWKDTQ LLTAIPTSPE PTGLEATAAS TSTLPAGEGP KEGEAVVLPE VEPGLTAREQ EATPRPRETT QLPTTHQAST TTATTAQEPA TSHPHRDMQP GHHETSTPAG PSQADLHTPH TEDGGPSATE RAAEDGASSQ LPAAEGSGEQ DFTFETSGEN TAVVAVEPDR RNQSPVDQGA TGASQGLLDR KEVLGGVIAV GLVGLIFAVC LVGFMLYRMK KKDEGSYSLE EPKQANGGAY QKPTKQEEFY A (1-310 aa encoded by BC008765)

Target Information

CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Bioinformatics

Protein Aliases: CD antigen 138; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; sCD138; soluble CD138; SYND1; syndecan proteoglycan 1; Syndecan-1; Syndecan1; synstatin

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Gene Aliases: AA408134; AA409076; CD138; HSPG; SDC; SDC1; Sstn; syn-1; Synd; Synd-1; SYND1; SYNDECA; Syndecan

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UniProt ID: (Human) P18827, (Mouse) P18828, (Rat) P26260

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Entrez Gene ID: (Human) 6382, (Mouse) 20969, (Rat) 25216

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Function(s)

glycoprotein binding protein binding protein C-terminus binding extracellular matrix binding transmembrane signal receptor

Process(es)

retinoid metabolic process ureteric bud development glycosaminoglycan biosynthetic process glycosaminoglycan catabolic process inflammatory response response to toxic substance cell migration glycosaminoglycan metabolic process wound healing lipoprotein metabolic process odontogenesis response to hydrogen peroxide myoblast development response to glucocorticoid response to cAMP response to calcium ion striated muscle cell development Sertoli cell development canonical Wnt signaling pathway positive regulation of exosomal secretion positive regulation of extracellular exosome assembly cell adhesion cell-cell signaling response to organic substance

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD138/Syndecan-1 Polyclonal Antibody

CD138/Syndecan-1 Antibody (10593-1-AP) in IHC (P)

Product Details

10593-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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