Product References
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.
Frontiers in immunology
Masle-Farquhar E,Jeelall Y,White J,Bier J,Deenick EK,Brink R,Horikawa K,Goodnow CC
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Mon Mar 27 00:00:00 EDT 2023
HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression.
Theranostics
Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Tue Apr 18 00:00:00 EDT 2023
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis.
Frontiers in immunology
Ma B,Kamle S,Akosman B,Khan H,Lee CM,Lee CG,Elias JA
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Tue Jan 10 00:00:00 EST 2023
Nanoliposome C6-Ceramide in combination with anti-CTLA4 antibody improves anti-tumor immunity in hepatocellular cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Qi X,Wu F,Kim SH,Kaifi JT,Kimchi ET,Snyder H,Illendula A,Fox T,Kester M,Staveley-O'Carroll KF,Li G
12-1522-82 was used in Flow cytometry/Cell sorting to investigate the potential of LipC6 in combination with immune checkpoint blockade in hepatocellular cancer treatment.
Fri Apr 01 00:00:00 EDT 2022
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
JCI insight
Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Mon Jan 25 00:00:00 EST 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
12-1522-82 was used in Flow cytometry/Cell sorting to suggest that graded RhoA expression in Treg cells distinguishes tumor immunity from autoimmunity and that rational targeting of RhoA in Treg cells may trigger anti-tumor T cell immunity without causing autoimmune responses.
Tue Jan 11 00:00:00 EST 2022
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
12-1522-82 was used in Flow cytometry/Cell sorting to suggest that graded RhoA expression in Treg cells distinguishes tumor immunity from autoimmunity and that rational targeting of RhoA in Treg cells may trigger anti-tumor T cell immunity without causing autoimmune responses.
Tue Jan 11 00:00:00 EST 2022
Anti-PD-1 Checkpoint Therapy Can Promote the Function and Survival of Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vick SC,Kolupaev OV,Perou CM,Serody JS
12-1522-82 was used in Flow cytometry/Cell sorting to show that this immunotherapy blockade increases proliferation, protection from apoptosis, and suppressive capabilities of Tregs, thus leading to enhanced immunosuppression in the TME.
Mon Nov 15 00:00:00 EST 2021
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Nature communications
Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N
12-1522-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.
Tue Nov 23 00:00:00 EST 2021
Downregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity.
International journal of molecular sciences
Lou Y,Wang J,Peng P,Wang S,Liu P,Xu LX
12-1522-82 was used in Flow Cytometry to reveal that cryo-thermal therapy could reprogram the suppressive environment and induce strong and durable antitumor immunity, which facilitate the development of combination strategies in immunotherapy.
Wed Sep 15 00:00:00 EDT 2021
Downregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity.
International journal of molecular sciences
Lou Y,Wang J,Peng P,Wang S,Liu P,Xu LX
12-1522-82 was used in Flow Cytometry to reveal that cryo-thermal therapy could reprogram the suppressive environment and induce strong and durable antitumor immunity, which facilitate the development of combination strategies in immunotherapy.
Wed Sep 15 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling.
Science signaling
Mendu SK,Stremska ME,Schappe MS,Moser EK,Krupa JK,Rogers JS,Stipes EJ,Parker CA,Braciale TJ,Perry JSA,Desai BN
12-1522-82 was used in Flow Cytometry to demonstrate that inhibition of the dual ion channel and enzyme, TRPM7, increases thymic development of regulatory T cells in mice.
Tue Dec 08 00:00:00 EST 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Fri Jun 26 00:00:00 EDT 2020
L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
Cells
Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC
12-1522 was used in Flow cytometry/Cell sorting to investigate the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis.
Wed Apr 29 00:00:00 EDT 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
12-1522 was used in Flow cytometry/Cell sorting to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 EST 2020
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology
Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA
12-1522 was used in Flow cytometry/Cell sorting to investigate how a mutation in an L-Type calcium channel gene influences T lymphocyte dysfunction.
Thu Oct 29 00:00:00 EDT 2020
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology
Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA
12-1522 was used in Flow cytometry/Cell sorting to investigate how a mutation in an L-Type calcium channel gene influences T lymphocyte dysfunction.
Thu Oct 29 00:00:00 EDT 2020
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
12-1522-82 was used in Flow cytometry/Cell sorting to show that CD160 is not essential for NKT cell development.
Mon Jul 22 00:00:00 EDT 2019
CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge.
PLoS neglected tropical diseases
Pontes Ferreira C,Cariste LM,Ferri Moraschi B,Ferrarini Zanetti B,Won Han S,Araki Ribeiro D,Vieira Machado A,Lannes-Vieira J,Gazzinelli RT,Vasconcelos JRC
12-1522 was used in Flow cytometry/Cell sorting to study how CXCR3 and its ligands drive Trypanosoma cruzi-specific effector CD8+ T-cells into infected heart tissue.
Mon Jul 01 00:00:00 EDT 2019
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
12-1522 was used in Flow cytometry/Cell sorting to set the foundation and show the importance of a combinatorial therapeutic strategy using pulsatile targeted therapy together with immunotherapy to optimally enhance tumor delay and promote long-term anti-tumor immunity.
Tue Apr 16 00:00:00 EDT 2019
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Cell stem cell
Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J
12-1522-82 was used in Flow Cytometry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.
Thu Mar 01 00:00:00 EST 2018
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.
British journal of pharmacology
Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
12-1522 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
12-1522 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8+ T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection.
Frontiers in immunology
Ferreira CP,Cariste LM,Santos Virgílio FD,Moraschi BF,Monteiro CB,Vieira Machado AM,Gazzinelli RT,Bruna-Romero O,Menin Ruiz PL,Ribeiro DA,Lannes-Vieira J,Lopes MF,Rodrigues MM,de Vasconcelos JRC
12-1522 was used in Flow cytometry/Cell sorting to explore the roles of LFA-1 and VLA-4 in the migration of specific CD8+ T cells generated by heterologous prime-boost immunisation during experimental infection with Trypanosoma cruzi.
Wed Nov 20 00:00:00 EST 2019
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Tue Jun 27 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells.
Scientific reports
Itakura G,Ozaki M,Nagoshi N,Kawabata S,Nishiyama Y,Sugai K,Iida T,Kashiwagi R,Ookubo T,Yastake K,Matsubayashi K,Kohyama J,Iwanami A,Matsumoto M,Nakamura M,Okano H
12-1522 was used in Flow cytometry/Cell sorting to evaluate the immunogenicity of mouse fetal neural stem/progenitor cells and iPSC derived neural stem/progenitor cells in vivtro and in vivo.
Wed Oct 11 00:00:00 EDT 2017
A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells.
PLoS pathogens
Ersching J,Basso AS,Kalich VL,Bortoluci KR,Rodrigues MM
12-1522 was used in Flow cytometry/Cell sorting to demonstrate a newly described mechanism of CD8+ T cell priming by CD4+ Foxp3+ T cells during Trypanosoma cruzi infection.
Wed Jun 01 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
12-1522 was used in Flow cytometry/Cell sorting to suggest persistent viral lytic gene expression during latency causes chronic inflammatory response inducing exhaustion of resident T cells in the ependyma.
Mon Aug 15 00:00:00 EDT 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
12-1522 was used in Flow cytometry/Cell sorting to study how tumour eradication can be controlled by interdependent IL-7 and IFN-γ signalling in T-cells.
Mon Aug 08 00:00:00 EDT 2016
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
EMBO molecular medicine
Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H
12-1522 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.
Mon Jun 01 00:00:00 EDT 2015
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Shock (Augusta, Ga.)
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
12-1522 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.
Thu Jan 01 00:00:00 EST 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD152 (CTLA-4) monoclonal antibody (Product # 12-1522-82) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells.
Oncotarget
Yuan CH,Sun XM,Zhu CL,Liu SP,Wu L,Chen H,Feng MH,Wu K,Wang FB
12-1522 was used in Flow cytometry/Cell sorting to investigate how hepatocellular carcinoma cells alter endogenous anti-tumor immunity and their related signaling pathways.
Tue Oct 13 00:00:00 EDT 2015
Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells.
Journal of molecular cell biology
Liu Y,Lan Q,Lu L,Chen M,Xia Z,Ma J,Wang J,Fan H,Shen Y,Ryffel B,Brand D,Quismorio F,Liu Z,Horwitz DA,Xu A,Zheng SG
12-1522 was used in Flow cytometry/Cell sorting to characterise the function and phenotype of a novel CD8+ Foxp3- CD103+ regulatory T cell.
Sat Feb 01 00:00:00 EST 2014
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Journal of leukocyte biology
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
12-1522 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.
Sat Nov 01 00:00:00 EDT 2014
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.
Nature communications
Kuwahara M,Suzuki J,Tofukuji S,Yamada T,Kanoh M,Matsumoto A,Maruyama S,Kometani K,Kurosaki T,Ohara O,Nakayama T,Yamashita M
12-1522 was used in Flow cytometry/Cell sorting to show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype after antigenic stimulation and dysregulated cytokine production.
Wed Apr 02 00:00:00 EDT 2014
Nematode asparaginyl-tRNA synthetase resolves intestinal inflammation in mice with T-cell transfer colitis.
Clinical and vaccine immunology : CVI
Kron MA,Metwali A,Vodanovic-Jankovic S,Elliott D
12-1522 was used in Flow cytometry/Cell sorting to demonstrates a novel anti-inflammatory nematode protein which supports continued refinement of alternative immunotherapies for treatment of IBD.
Fri Feb 01 00:00:00 EST 2013
Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.
PloS one
Schijf MA,Kerperien J,Bastiaans J,Szklany K,Meerding J,Hofman G,Boon L,van Wijk F,Garssen J,Van't Land B
12-1522 was used in Flow cytometry/Cell sorting to identify factors affecting the quality of the immune response to vaccination.
Tue May 27 00:00:00 EDT 2014
Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.
Nature biotechnology
Getts DR,Martin AJ,McCarthy DP,Terry RL,Hunter ZN,Yap WT,Getts MT,Pleiss M,Luo X,King NJ,Shea LD,Miller SD
12-1522 was used in Flow cytometry/Cell sorting to highlight the potential for using microparticles to target natural apoptotic clearance pathways to inactivate pathogenic T cells in autoimmunity.
Sat Dec 01 00:00:00 EST 2012
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Cellular & molecular immunology
Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L
12-1522 was used in Flow cytometry/Cell sorting to provide a novel understanding of the interaction between iTregs and DCs, and its role in iTreg-mediated immune suppression.
Thu Mar 01 00:00:00 EST 2012
Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.
PloS one
Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X
12-1522 was used in Flow cytometry/Cell sorting to demonstrate that soluble divalent MHC class II molecules can abrogate pathogenic T cells in experimental autoimmune encephalomyelitis.
Fri Jul 19 00:00:00 EDT 2013
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
12-1522 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 EDT 2011
In vivo expansion of regulatory T cells with IL-2/IL-2 mAb complexes prevents anti-factor VIII immune responses in hemophilia A mice treated with factor VIII plasmid-mediated gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Liu CL,Ye P,Yen BC,Miao CH
12-1522 was used in Flow cytometry/Cell sorting to demonstrate the important role of Tregs in suppressing anti-FVIII immune responses, and the potential of developing Treg expansion therapies that induce long-term tolerance to FVIII.
Mon Aug 01 00:00:00 EDT 2011
CD4+ Foxp3+ regulatory T cells mediate Toxoplasma gondii-induced T-cell suppression through an IL-2-related mechanism but independently of IL-10.
European journal of immunology
Tenorio EP,Fernández J,Castellanos C,Olguín JE,Saavedra R
12-1522 was used in Flow cytometry/Cell sorting to study the role of Treg cells in Toxoplasma gondii induced suppression.
Thu Dec 01 00:00:00 EST 2011
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.
Aging cell
Lages CS,Lewkowich I,Sproles A,Wills-Karp M,Chougnet C
12-1522 was used in Flow cytometry/Cell sorting to suggest that blockade of the PD-1/PD-L1 is not likely to be efficient at restoring exhausted T-cell responses in aged hosts.
Fri Oct 01 00:00:00 EDT 2010
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee H,Lee H,Kwon Y,Lee JH,Kim J,Shin MK,Kim SH,Bae H
12-1522 was used in Flow cytometry/Cell sorting to study effect of Methyl gallate on Treg cells, leading to reduced tumour growth, due to reversing immune suppression.
Wed Dec 01 00:00:00 EST 2010
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.
The Journal of experimental medicine
Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J
12-1522 was used in Flow cytometry/Cell sorting to study the role of T reg cells in the induction of resistance to EAE and long term acceptance of islet allografts.
Mon Apr 13 00:00:00 EDT 2009
Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.
Journal of immunology (Baltimore, Md. : 1950)
Walsh KP,Brady MT,Finlay CM,Boon L,Mills KH
12-1522 was used in Flow cytometry/Cell sorting to provide evidence that parasites can exert bystander immunosuppression of pathogenic T cells that mediate autoimmune diseases.
Sat Aug 01 00:00:00 EDT 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
12-1522 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
Blood
Peng B,Ye P,Blazar BR,Freeman GJ,Rawlings DJ,Ochs HD,Miao CH
12-1522 was used in Flow cytometry/Cell sorting to study the formation of inhibitory antibodies during treatment of hemophilia, showing that transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII.
Mon Sep 01 00:00:00 EDT 2008
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Luo X,Tarbell KV,Yang H,Pothoven K,Bailey SL,Ding R,Steinman RM,Suthanthiran M
12-1522 was used in Flow cytometry/Cell sorting to reveal a role for DCs in the induction of antigen-specific CD4(+)CD25(+)Foxp3(+) T cells.
Tue Feb 20 00:00:00 EST 2007
Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells.
International immunology
Park HB,Paik DJ,Jang E,Hong S,Youn J
12-1522 was used in Flow cytometry/Cell sorting to investigate the potential role of TGF-beta in the peripheral induction of regulatory phenotypes in conventional CD4(+)CD25(-) T cells.
Sun Aug 01 00:00:00 EDT 2004
