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Invitrogen
CD16/CD32 Monoclonal Antibody (93), PE-Cyanine7
Product Details
A14719
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG2a, lambda
Class
Monoclonal
Type
Antibody
Clone
93
Immunogen
Mouse CD16 and CD32 (common epitope).
Conjugate
Excitation/Emission Max
569/780 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.1, with proprietary stabilizer
Contains
<0.1% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2534235
Target Information
CD16 is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by natural killer (NK) cells, and some T cells and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC (antibody dependent cell mediated cytotoxicity) by NK cells. IN comparison, CD32 is a 40 kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII), and mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets. Further, CD32 is involved in the phagocytosis of immune complexes, the regulation of antibody production by B-cells, and variations of the CD32 gene may increase vulnerability to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms of CD32 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD16A; CD16B; CD32; CD32 receptor 2; Fc gamma receptor IIB; Fc gamma receptor III; Fc gamma RIIB; Fc-gamma RII; fc-gamma RIII; Fc-gamma-RII; fc-gamma-RIIB; Fcg receptor III; FCG2; FcgammaRIIB; FcgammaRIII; FCGR2C; FCGR3A; FCGR3B; FCGRIII; FCR-10; FcRII-b; FcRII-c; fcRIII; FCRIIIA; FGFR2B; IgG Fc receptor II beta; igG Fc receptor III; Low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; low affinity immunoglobulin gamma Fc region receptor III; Ly-17; Lymphocyte antigen 17; RP11-5K23.1
Gene Aliases: AI528646; CD16; CD32; F630109E10Rik; Fc[g]RII; Fcgr2; Fcgr2a; Fcgr2b; FcgRII; Fcr-2; Fcr-3; fcRII; Ly-17; Ly-m20; LyM-1
UniProt ID: (Mouse) P08101
Entrez Gene ID: (Mouse) 14130, (Mouse) 14131
negative regulation of type I hypersensitivity
immune complex clearance
negative regulation of immunoglobulin production
negative regulation of inflammatory response to antigenic stimulus
negative regulation of acute inflammatory response to antigenic stimulus
negative regulation of humoral immune response mediated by circulating immunoglobulin
receptor-mediated endocytosis
phagocytosis, engulfment
defense response
immune response
cell surface receptor signaling pathway
response to bacterium
immunoglobulin mediated immune response
antigen processing and presentation of exogenous peptide antigen via MHC class II
negative regulation of B cell proliferation
endocytic recycling
negative regulation of interleukin-10 production
negative regulation of neutrophil apoptotic process
intracellular signal transduction
mast cell activation
negative regulation of phagocytosis
positive regulation of phagocytosis
negative regulation of immune response
cellular response to molecule of bacterial origin
antibody-dependent cellular cytotoxicity
positive regulation of type IIa hypersensitivity
positive regulation of type III hypersensitivity
positive regulation of type I hypersensitivity
serotonin secretion
phagocytosis, recognition
neutrophil chemotaxis
Fc-gamma receptor signaling pathway
positive regulation of tumor necrosis factor biosynthetic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
regulation of immune response
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