Invitrogen

CD169 Monoclonal Antibody (HSn 7D2)

CD169 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 2

CD169 Antibody (MA1-16891) in IHC (P)

Immunohistochemical analysis of CD169 in human spleen. Samples were incubated in CD169 monoclonal antibody (Product # MA1-16891) followed by DAB with hematoxylin counterstain.

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Product Details

MA1-16891

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-Dependent

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:500

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

1:10-1:500

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-Dependent

Flow Cytometry (Flow)

1:10-1:1,000

ELISA (ELISA)

1:100-1:2,000

Radioimmune Assays (RIA)

Assay-Dependent

In vitro Assay (IV)

Assay-Dependent

Product Specifications

Species Reactivity

Human, Mouse, Pig, Virus

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

HSn 7D2

Immunogen

Full length hSn(d1-4)Fc protein (purified) (Human).

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568734

Target Information

The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Peripheral monocytes are functionally altered and invade the CNS in ALS patients.

Acta neuropathologica

Zondler L,Müller K,Khalaji S,Bliederhäuser C,Ruf WP,Grozdanov V,Thiemann M,Fundel-Clemes K,Freischmidt A,Holzmann K,Strobel B,Weydt P,Witting A,Thal DR,Helferich AM,Hengerer B,Gottschalk KE,Hill O,Kluge M,Ludolph AC,Danzer KM,Weishaupt JH

MA116891 was used in western blot to find that central nervous system infiltration of peripheral monocytes correlates with improved motor neuron survival in a genetic amyotrophic lateral sclerosis mouse model

Thu Sep 01 00:00:00 EDT 2016

The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone.

Immunology

Steiniger B,Barth P,Herbst B,Hartnell A,Crocker PR

MA116891 was used in immunohistochemistry with frozen sections to show sialoadhesin-positive macrophages in the perifollicular zone.

Wed Oct 01 00:00:00 EDT 1997

The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone.

Immunology

Steiniger B,Barth P,Herbst B,Hartnell A,Crocker PR

MA116891 was used in immunohistochemistry with frozen sections to show sialoadhesin-positive macrophages in the perifollicular zone.

Wed Oct 01 00:00:00 EDT 1997

Bioinformatics

Protein Aliases: CD169; macrophage receptor; p210; pSn; SER; Sheep erythrocyte receptor; sialic acid binding Ig-like lectin 1, sialoadhesin; Sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1; Sialoadhesin; Siglec-1

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Gene Aliases: CD169; dJ1009E24.1; p210; pSn; SA; SIGLEC-1; SIGLEC1; SN

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UniProt ID: (Pig) A7LCJ3, (Human) Q9BZZ2, (Mouse) Q62230

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Entrez Gene ID: (Pig) 397623, (Human) 6614, (Mouse) 20612

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Function(s)

virus receptor activity protein binding carbohydrate binding virion binding

Process(es)

cell adhesion viral entry into host cell negative regulation of phagocytosis clathrin-mediated endocytosis clathrin-dependent endocytosis of virus by host cell endocytosis inflammatory response cell-matrix adhesion single organismal cell-cell adhesion positive regulation of T cell apoptotic process positive regulation of extrinsic apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD169 Monoclonal Antibody (HSn 7D2)

CD169 Antibody (MA1-16891) in IHC (P)

Product Details

MA1-16891

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ELISA (ELISA)

Radioimmune Assays (RIA)

In vitro Assay (IV)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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