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Product Details
MA5-16492
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fish,
Mouse,
Pig
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2F8
Immunogen
Raw 264 cell line
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538003
Product Specific Information
In Western blot, this product recognizes CD204 in J774 cells under non-reducing conditions only. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD204; Macrophage acetylated LDL receptor I and II; Macrophage scavenger receptor types I and II; Scavenger receptor type A; SR-A; SR-AI/II
Gene Aliases: MRS-A; MSR; MSR-A; Msr1; Scara1; Scvr; SR-AI; SR-AII
UniProt ID: (Mouse) P30204
Entrez Gene ID: (Pig) 100511665, (Mouse) 20288
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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