Invitrogen

CD206 (MMR) Monoclonal Antibody (MR6F3), APC, eBioscience™

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Antibody Testing Data (1)
Published Figures (63)

CD206 (MMR) Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 64

CD206 (MMR) Antibody (17-2061-80) in Flow

Mouse resident peritoneal exudate cells were surface stained with Anti-Mouse F4/80 Antigen eFluor® 450 (Product # 48-4801-82) followed by fixation and permeabilization with the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00). Cells were then intracellularly stained with 0.125 µg of Rat IgG2b K Isotype Control APC (Product # 17-4031-82) (left) or 0.125 µg of Anti-Mouse CD206 (MMR) APC (right). Total cells were used for analysis.

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Product Details

17-2061-80

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.25 µg/test

View 56 publications 56 publications

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), APC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

MR6F3

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2637419

Product Specific Information

Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. CD206 belongs to the C-type lectin family. Extracellular regions of CD206 include an N-terminal cysteine-rich (CR) domain that binds sulfated glycoproteins, a fibronectin II (FNII) domain that binds collagens, and eight carbohydrate recognition domains (CRDs) that bind sugars like mannose and fucose with high affinity. CD206 mediates phagocytic and endocytic uptake of fungal, bacterial, protozoan and viral antigens, and plays an important role in immune defense and immune regulation. A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. CD206 is considered to be one of the markers of M2 macrophages. Factors inducing its expression include: IL-4, IL-13, M-CSF, IL-6, IL-10, and glucocorticoids, while TNF-alpha, IFN-gamma, TGF-beta, and LPS have been reported to down-regulate expression of CD206.

It has been demonstrated that only a small fraction of CD206 is present at the cell surface, therefore, intracellular staining is recommended.

Applications Reported: This MR6F3 antibody has been reported for use in flow cytometric analysis, and intracellular staining followed by flow cytometric analysis.

Applications Tested: This MR6F3 antibody has been tested by intracellular staining and flow cytometric analysis of mouse resident peritoneal exudate cells using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum.

Journal of cellular and molecular medicine

Zhu D,Huang M,Shen P,Zhang B,Chen G,Chen J,Duan L,Duan Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

A pref-1-controlled non-inflammatory mechanism of insulin resistance.

iScience

Huang Y,Cui D,Chen L,Tong H,Wu H,Muller GK,Qi Y,Wang S,Xu J,Gao X,Fifield KE,Wang L,Xia Z,Vanderluit JL,Liu S,Leng L,Sun G,McGuire J,Young LH,Bucala R,Qi D

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Fri Jun 16 00:00:00 EDT 2023

Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects.

Bioactive materials

Li S,Zhang L,Liu C,Kim J,Su K,Chen T,Zhao L,Lu X,Zhang H,Cui Y,Cui X,Yuan F,Pan H

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2023

Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization.

iScience

Luo JQ,Ren H,Chen MY,Zhao Q,Yang N,Liu Q,Gao YC,Zhou HH,Huang WH,Zhang W

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Fri Jul 21 00:00:00 EDT 2023

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Zuo B,Li T,Liu X,Wang S,Cheng J,Liu X,Cui W,Shi H,Ling C

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2023

MIR222HG attenuates macrophage M2 polarization and allergic inflammation in allergic rhinitis by targeting the miR146a-5p/TRAF6/NF-κB axis.

Frontiers in immunology

Wen S,Li F,Tang Y,Dong L,He Y,Deng Y,Tao Z

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Fri May 26 00:00:00 EDT 2023

Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing.

Signal transduction and targeted therapy

Liu W,Chen W,Xie M,Chen C,Shao Z,Zhang Y,Zhao H,Song Q,Hu H,Xing X,Cai X,Deng X,Li X,Wang P,Liu G,Xiong L,Lv X,Zhang Y

17-2061-82 was used in Flow cytometry/Cell sorting to conclude that TBI accelerates bone formation during early stage of fracture healing process by shaping the anti-inflammation environment in the bone marrow.

Wed Jul 05 00:00:00 EDT 2023

Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing.

Signal transduction and targeted therapy

Liu W,Chen W,Xie M,Chen C,Shao Z,Zhang Y,Zhao H,Song Q,Hu H,Xing X,Cai X,Deng X,Li X,Wang P,Liu G,Xiong L,Lv X,Zhang Y

Wed Jul 05 00:00:00 EDT 2023

Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.

Veterinary research

Feng L,Luo G,Li Y,Zhang C,Liu Y,Liu Y,Chen H,He D,Zhu Y,Gan L

17-2061-82 was used in Flow cytometry/Cell sorting to demonstrate that CUR protected against PRV-induced viral encephalitis by switching the phenotype of BV2 cells, thereby protecting neurons from inflammatory injury, and this effect was mediated by improving mitochondrial function and the AMPK/NF-κB p65-energy metabolism-related pathway.

Tue Mar 14 00:00:00 EDT 2023

Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.

Veterinary research

Feng L,Luo G,Li Y,Zhang C,Liu Y,Liu Y,Chen H,He D,Zhu Y,Gan L

Tue Mar 14 00:00:00 EDT 2023

BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization.

NPJ Regenerative medicine

Wang J,Xue Y,Wang Y,Liu C,Hu S,Zhao H,Gu Q,Yang H,Huang L,Zhou X,Shi Q

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Thu Feb 09 00:00:00 EST 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

17-2061-82 was used in Flow cytometry/Cell sorting to develop an oxygen-carrying nanoplatform loaded with perfluorooctyl bromide (PFOB, a second-generation of perfluorocarbon-based blood substitute), IR780 (a photosensitizer) and imiquimod (R837, an immune adjuvant) to reprogram immunosuppressive TME and reinforce photothermal-immunotherapy.

Sat Apr 01 00:00:00 EDT 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

Sat Apr 01 00:00:00 EDT 2023

Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization.

Frontiers in bioengineering and biotechnology

Yang N,Shi N,Yao Z,Liu H,Guo W

17-2061-82 was used in Flow cytometry/Cell sorting to develop gallium-modified gelatin nanoparticles loaded with quercetin, which demonstrated biocompatibility, enhanced fibroblast function, anti-bacterial capacity, inflammation suppression, and scar inhibition during wound healing.

Tue Feb 14 00:00:00 EST 2023

Targeting Notch1-YAP Circuit Reprograms Macrophage Polarization and Alleviates Acute Liver Injury in Mice.

Cellular and molecular gastroenterology and hepatology

Yang Y,Ni M,Zong R,Yu M,Sun Y,Li J,Chen P,Li C

17-2061-82 was used in Flow cytometry/Cell sorting to underscore a novel molecular insight into the Notch1-YAP circuit for controlling macrophage polarization in acute liver injury, raising the possibility of targeting macrophage Notch1-YAP circuit as an effective strategy for liver inflammation-related diseases.

Mon Apr 24 00:00:00 EDT 2023

Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy.

Immunity, inflammation and disease

Li P,Ji X,Shan M,Wang Y,Dai X,Yin M,Liu Y,Guan L,Ye L,Cheng H

17-2061-82 was used in Flow cytometry/Cell sorting to find that melatonin had a significant protective effect in LPS-treated BV-2 cells and ROCK-KD cells, while the protective effect of melatonin was significantly attenuated in ROCK-OE cells.

Thu Jun 01 00:00:00 EDT 2023

L-norvaline affects the proliferation of breast cancer cells based on the microbiome and metabolome analysis.

Journal of applied microbiology

Zhu Q,Zai H,Zhang K,Zhang X,Luo N,Li X,Hu Y,Wu Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2022

G9a promotes inflammation in Streptococcus pneumoniae induced pneumonia mice by stimulating M1 macrophage polarization and H3K9me2 methylation in FOXP1 promoter region.

Annals of translational medicine

Li Y,Li G,Zhang L,Li Y,Zhao Z

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2022

Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.

Cancer immunology research

Wu Q,Huang Q,Jiang Y,Sun F,Liang B,Wang J,Hu X,Sun M,Ma Z,Shi Y,Liang Y,Tan Y,Zeng D,Yao F,Xu X,Yao Z,Li S,Rong X,Huang N,Sun L,Liao W,Shi M

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Tue Feb 01 00:00:00 EST 2022

Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy.

JCI insight

Howard ZM,Gomatam CK,Rabolli CP,Lowe J,Piepho AB,Bansal SS,Accornero F,Rafael-Fortney JA

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon Oct 10 00:00:00 EDT 2022

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.

Journal of nanobiotechnology

Li K,Yan G,Huang H,Zheng M,Ma K,Cui X,Lu D,Zheng L,Zhu B,Cheng J,Zhao J

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Thu Jan 20 00:00:00 EST 2022

TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.

Biology

Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Thu Nov 03 00:00:00 EDT 2022

EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis.

Cell death & disease

Zhang X,Chen C,Ling C,Luo S,Xiong Z,Liu X,Liao C,Xie P,Liu Y,Zhang L,Chen Z,Liu Z,Tang J

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon Nov 07 00:00:00 EST 2022

Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.

International journal of biological sciences

Qian Z,Chen H,Xia M,Chang J,Li X,Ye S,Wu S,Jiang S,Bao J,Wang B,Kong R,Zhang S,Zheng S,Cao X,Hong X

17-2061-82 was used in Flow cytometry/Cell sorting to investigate glucagon-like peptide-1 receptor for neuroprotective effects in neurodegeneration.

Fri Apr 15 00:00:00 EDT 2022

Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.

International journal of biological sciences

Qian Z,Chen H,Xia M,Chang J,Li X,Ye S,Wu S,Jiang S,Bao J,Wang B,Kong R,Zhang S,Zheng S,Cao X,Hong X

17-2061-82 was used in Flow cytometry/Cell sorting to investigate glucagon-like peptide-1 receptor for neuroprotective effects in neurodegeneration.

Fri Apr 15 00:00:00 EDT 2022

Local and systemic inflammation triggers different outcomes of tumor growth related to infiltration of anti-tumor or pro-tumor macrophages.

Chinese medical journal

Liu X,Jiang Q,Shen S,Hou Y

17-2061-82 was used in Flow cytometry/Cell sorting to suggest that the different outcomes of tumor growth might be attributed to the infiltration of anti-tumor or pro-tumor immune cells, especially M1 or M2 type macrophages into tumor microenvironment.

Fri Aug 05 00:00:00 EDT 2022

Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.

Frontiers in immunology

Jiang F,Xia M,Zhang Y,Chang J,Cao J,Zhang Z,Qian Z,Yang L

17-2061-82 was used in Flow cytometry/Cell sorting to suggest that CB2R activation attenuated neuroinflammation targeting microglial polarization by promoting NLRP3 clearance, thereby facilitating functional recovery post-SCI.

Mon Oct 17 00:00:00 EDT 2022

MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis.

Cell death discovery

Wen Z,Lin S,Li C,Ouyang Z,Chen Z,Li S,Huang Y,Luo W,Zheng Z,Guo P,Kuang M,Ding Y

17-2061-82 was used in Flow cytometry/Cell sorting to suggest the key role of miR-92a/KLF4/p110δ signal in TiPs-induced macrophages inflammation and osteolysis.

Wed Apr 13 00:00:00 EDT 2022

Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization.

Stem cell research & therapy

Dong B,Wang C,Zhang J,Zhang J,Gu Y,Guo X,Zuo X,Pan H,Hsu AC,Wang G,Wang F

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Wed Mar 24 00:00:00 EDT 2021

Hyperoside Suppresses Renal Inflammation by Regulating Macrophage Polarization in Mice With Type 2 Diabetes Mellitus.

Frontiers in immunology

Liu J,Zhang Y,Sheng H,Liang C,Liu H,Moran Guerrero JA,Lu Z,Mao W,Dai Z,Liu X,Zhang L

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Thu Feb 10 00:00:00 EST 2022

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

Cells

Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon Nov 15 00:00:00 EST 2021

Azithromycin alleviates systemic lupus erythematosus via the promotion of M2 polarisation in lupus mice.

Cell death discovery

Wang J,Chen Q,Zhang Z,Wang S,Wang Y,Xiang M,Liang J,Xu J

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Fri Apr 16 00:00:00 EDT 2021

Resolving macrophage polarization through distinct Ca²⁺ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.

iScience

Nascimento Da Conceicao V,Sun Y,Ramachandran K,Chauhan A,Raveendran A,Venkatesan M,DeKumar B,Maity S,Vishnu N,Kotsakis GA,Worley PF,Gill DL,Mishra BB,Madesh M,Singh BB

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Fri Nov 19 00:00:00 EST 2021

Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.

Frontiers in pharmacology

Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Sat Apr 02 00:00:00 EDT 2022

Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.

Stem cell research & therapy

Wang F,Kong L,Wang W,Shi L,Wang M,Chai Y,Xu J,Kang Q

17-2061 was used in Flow cytometry/Cell sorting to indicate that ADM2 enhances diabetic bone regeneration during DO, by attenuating AGE-induced imbalances in macrophage polarization, partly through PPARγ/NF-κB signaling, and improving AGE-impaired osteogenic differentiation of BMSCs simultaneously.

Thu May 13 00:00:00 EDT 2021

Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.

Stem cell research & therapy

Wang F,Kong L,Wang W,Shi L,Wang M,Chai Y,Xu J,Kang Q

Thu May 13 00:00:00 EDT 2021

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway.

Frontiers in immunology

Kong F,Sun K,Zhu J,Li F,Lin F,Sun X,Luo X,Ren C,Lu L,Zhao S,Sun J,Wang Y,Shi J

17-2061 was used in Flow cytometry/Cell sorting to study the effect and mechanisms of programmed cell death ligand-1 on locomotor and sensory functions and neuropathic pain symptoms following spinal cord injury using a mouse model.

Mon Nov 01 00:00:00 EDT 2021

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway.

Frontiers in immunology

Kong F,Sun K,Zhu J,Li F,Lin F,Sun X,Luo X,Ren C,Lu L,Zhao S,Sun J,Wang Y,Shi J

Mon Nov 01 00:00:00 EDT 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice.

Communications biology

Song L,Chang R,Sun X,Lu L,Gao H,Lu H,Lin R,Xu X,Liu Z,Zhan L

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

3D GelMA ICC Scaffolds Combined with SW033291 for Bone Regeneration by Modulating Macrophage Polarization.

Pharmaceutics

Jiang Q,Bai G,Liu X,Chen Y,Xu G,Yang C,Zhang Z

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

Combination Foretinib and Anti-PD-1 Antibody Immunotherapy for Colorectal Carcinoma.

Frontiers in cell and developmental biology

Fu Y,Peng Y,Zhao S,Mou J,Zeng L,Jiang X,Yang C,Huang C,Li Y,Lu Y,Wu M,Yang Y,Kong T,Lai Q,Wu Y,Yao Y,Wang Y,Gou L,Yang J

17-2061-82 was used in flow cytometry to suggests that a novel combination therapy utilizing both Foretinib and anti-PD-1 antibody could be an effective combination strategy for CRC immunotherapy.

Tue Jul 27 00:00:00 EDT 2021

Potential role of senescent macrophages in radiation-induced pulmonary fibrosis.

Cell death & disease

Su L,Dong Y,Wang Y,Wang Y,Guan B,Lu Y,Wu J,Wang X,Li D,Meng A,Fan F

17-2061-82 was used in Flow Cytometry to provide important evidence that senescent macrophages might be the target for prevention and treatment of RIPF.

Sat May 22 00:00:00 EDT 2021

Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype.

International journal of medical sciences

Liu X,Xu Y,Li Y,Pan Y,Zhao S,Hou Y

17-2061-82 was used in Flow cytometry/Cell sorting to create a nanocomposite of Ferumoxytol (FMT) surface-coated with β-glucan (FMT-β-glucan), which effectively suppressed melanoma growth by promoting the polarization of M1 macrophages in the tumor microenvironment, enhancing the antitumor effect both in vivo and in vitro, likely through the upregulation of Dectin-1 and activation of MAPK and NF-κB signaling pathways in macrophages.

Mon Jan 10 00:00:00 EST 2022

The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.

Experimental & molecular medicine

Lee YS,Song SJ,Hong HK,Oh BY,Lee WY,Cho YB

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses.

Biomaterials science

Qiu J,Peng P,Xin M,Wen Z,Chen Z,Lin S,Kuang M,Fu Y,Fang G,Li S,Li C,Mao J,Qin L,Ding Y

17-2061 was used in Flow cytometry/Cell sorting to study the molecular mechanism(s) of zinc finger and BTB domain-containing protein 20 (ZBTB20) contributing to titanium particle (TiP)-induced macrophage inflammatory responses and osteolysis.

Sun Jun 07 00:00:00 EDT 2020

Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.

The journals of gerontology. Series A, Biological sciences and medical sciences

Mau T,O'Brien M,Ghosh AK,Miller RA,Yung R

17-2061 was used in Flow cytometry/Cell sorting to study the effects of three drugs identified in the Interventions Testing Program on inflammation in gonadal white adipose tissue of HET3 mice.

Wed Jan 01 00:00:00 EST 2020

Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.

Journal of cellular and molecular medicine

Wang Y,Han B,Wang Y,Wang C,Zhang H,Xue J,Wang X,Niu T,Niu Z,Chen Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

Mycobacterium tuberculosis Heat-Shock Protein 16.3 Induces Macrophage M2 Polarization Through CCRL2/CX3CR1.

Inflammation

Zhang Y,Li S,Liu Q,Long R,Feng J,Qin H,Li M,Liu L,Luo J

17-2061 was used in Flow cytometry/Cell sorting to provides evidence that Mycobacterium tuberculosis (MTB) Hsp16.3 promotes macrophages to M2 phenotype and explores its underlying mechanism.

Wed Apr 01 00:00:00 EDT 2020

Cardioprotective Effects of Latifolin Against Doxorubicin-Induced Cardiotoxicity by Macrophage Polarization in Mice.

Journal of cardiovascular pharmacology

Zhang N,Shou B,Chen L,Lai X,Luo Y,Meng X,Liu R

17-2061 was used in Flow cytometry/Cell sorting to demonstrate that latifolin prevented DOX-induced cardiac dysfunction and produced macrophage polarization in mice challenged with latifolin.

Mon Jun 01 00:00:00 EDT 2020

Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Jin S,Meng C,He Y,Wang X,Zhang Q,Wang Z,Huang W,Wang H

17-2061 was used in Flow cytometry/Cell sorting to examine the capacity of curcumin to prevent osteocyte apoptosis and glucocorticoid-associated osteonecrosis of the femoral head.

Tue Sep 01 00:00:00 EDT 2020

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.

Nature communications

Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon Jun 22 00:00:00 EDT 2020

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.

Journal of neuroinflammation

Kong FQ,Zhao SJ,Sun P,Liu H,Jie J,Xu T,Xu AD,Yang YQ,Zhu Y,Chen J,Zhou Z,Qian DF,Gu CJ,Chen Q,Yin GY,Zhang HW,Fan J

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Mon Feb 17 00:00:00 EST 2020

Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway.

Theranostics

Zhao SJ,Kong FQ,Jie J,Li Q,Liu H,Xu AD,Yang YQ,Jiang B,Wang DD,Zhou ZQ,Tang PY,Chen J,Wang Q,Zhou Z,Chen Q,Yin GY,Zhang HW,Fan J

17-2061 was used in Flow cytometry/Cell sorting to show bone marrow stem cell osteogenic differentiation and M2-like polarization is promoted by macrophage MSR1-mediated activation of the PI3K/AKT/GSK3β/β-catenin pathway.

Fri Apr 02 00:00:00 EDT 2021

Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment.

International journal of molecular sciences

Doty DT,Schueler J,Mott VL,Bryan CM,Moore NF,Ho JC,Borenstein JT

17-2061-82 was used in Flow Cytometry to assess the efficacy of two classes of ICIs against three syngeneic mouse tumor models exposed to flowing drug-treated lymphocytes.

Fri Sep 04 00:00:00 EDT 2020

Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

CNS neuroscience & therapeutics

Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

Integrated Functional Analysis of the Nuclear Proteome of Classically and Alternatively Activated Macrophages.

Mediators of inflammation

Wiktorowicz JE,Chowdhury IH,Stafford S,Choudhuri S,Dey N,Garg NJ

17-2061 was used in Flow cytometry/Cell sorting to capture quantitative changes in abundance and S-nitrosylated (SNO) proteome signatures.

Mon Dec 16 00:00:00 EST 2019

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.

Journal for immunotherapy of cancer

Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Anti-Bacterial Effect of CpG-DNA Involves Enhancement of the Complement Systems.

International journal of molecular sciences

Kim TH,Park J,Kim D,Gautam A,Akauliya M,Kim J,Lee H,Park S,Lee Y,Kwon HJ

17-2061-82 was used in Flow Cytometry to suggest that CpG-DNA enhances the anti-bacterial activity of the immune system by augmenting the levels of complement systems after E. coli K1 infection and triggering other factors as well.

Wed Jul 10 00:00:00 EDT 2019

Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype.

Frontiers in pharmacology

Guo M,Xiao J,Sheng X,Zhang X,Tie Y,Wang L,Zhao L,Ji X

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone.

Journal of neuroinflammation

Yin X,Feng L,Ma D,Yin P,Wang X,Hou S,Hao Y,Zhang J,Xin M,Feng J

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Tue Mar 27 00:00:00 EDT 2018

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.

Scientific reports

Gao S,Li C,Zhu Y,Wang Y,Sui A,Zhong Y,Xie B,Shen X

Published figure using CD206 (MMR) monoclonal antibody (Product # 17-2061-82) in Flow Cytometry

Fri Feb 17 00:00:00 EST 2017

Bioinformatics

Protein Aliases: CD206; Macrophage mannose receptor 1; MMR

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Gene Aliases: AW259686; CD206; MR; Mrc1

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UniProt ID: (Mouse) Q61830

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Entrez Gene ID: (Mouse) 17533

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Function(s)

receptor activity transmembrane signaling receptor activity mannose binding carbohydrate binding

Process(es)

endocytosis receptor-mediated endocytosis signal transduction cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-4

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CD206 (MMR) Monoclonal Antibody (MR6F3), APC, eBioscience™

CD206 (MMR) Antibody (17-2061-80) in Flow

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17-2061-80

Flow Cytometry (Flow)

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