Invitrogen

CD206 (MMR) Monoclonal Antibody (MR6F3), PE-Cyanine7, eBioscience™

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Antibody Testing Data (1)
Published Figures (53)

CD206 (MMR) Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 54

CD206 (MMR) Antibody (25-2061-82) in Flow

Mouse resident peritoneal exudate cells were surface stained with Anti-Mouse F4/80 Antigen eFluor® 450 (Product # 48-4801-82) followed by fixation and permeabilization with the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00). Cells were then intracellularly stained with 0.125 µg of Rat IgG2b K Isotype Control PE-Cyanine7 (Product # 25-4031-82) (left) or 0.125 µg of Anti-Mouse CD206 (MMR) PE-Cyanine7 (right). Total cells were used for analysis.

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Product Details

25-2061-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.25 µg/test

View 42 publications 42 publications

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), PE-Cyanine7, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

MR6F3

Conjugate

PE-Cyanine7 PE-Cyanine7 PE-Cyanine7

Excitation/Emission Max

569/780 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2637424

Product Specific Information

Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. CD206 belongs to the C-type lectin family. Extracellular regions of CD206 include an N-terminal cysteine-rich (CR) domain that binds sulfated glycoproteins, a fibronectin II (FNII) domain that binds collagens, and eight carbohydrate recognition domains (CRDs) that bind sugars like mannose and fucose with high affinity. CD206 mediates phagocytic and endocytic uptake of fungal, bacterial, protozoan and viral antigens, and plays an important role in immune defense and immune regulation. A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. CD206 is considered to be one of the markers of M2 macrophages. Factors inducing its expression include: IL-4, IL-13, M-CSF, IL-6, IL-10, and glucocorticoids, while TNF-alpha, IFN-gamma, TGF-beta, and LPS have been reported to down-regulate expression of CD206.

It has been demonstrated that only a small fraction of CD206 is present at the cell surface, therefore, intracellular staining is recommended.

Applications Reported: This MR6F3 antibody has been reported for use in flow cytometric analysis, and intracellular staining followed by flow cytometric analysis.

Applications Tested: This MR6F3 antibody has been tested by intracellular staining and flow cytometric analysis of mouse resident peritoneal exudate cells using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00 and protocol. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL of cell sample + 100 µL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum.

Journal of cellular and molecular medicine

Zhu D,Huang M,Shen P,Zhang B,Chen G,Chen J,Duan L,Duan Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

A pref-1-controlled non-inflammatory mechanism of insulin resistance.

iScience

Huang Y,Cui D,Chen L,Tong H,Wu H,Muller GK,Qi Y,Wang S,Xu J,Gao X,Fifield KE,Wang L,Xia Z,Vanderluit JL,Liu S,Leng L,Sun G,McGuire J,Young LH,Bucala R,Qi D

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri Jun 16 00:00:00 EDT 2023

Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects.

Bioactive materials

Li S,Zhang L,Liu C,Kim J,Su K,Chen T,Zhao L,Lu X,Zhang H,Cui Y,Cui X,Yuan F,Pan H

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2023

Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization.

iScience

Luo JQ,Ren H,Chen MY,Zhao Q,Yang N,Liu Q,Gao YC,Zhou HH,Huang WH,Zhang W

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri Jul 21 00:00:00 EDT 2023

MIR222HG attenuates macrophage M2 polarization and allergic inflammation in allergic rhinitis by targeting the miR146a-5p/TRAF6/NF-κB axis.

Frontiers in immunology

Wen S,Li F,Tang Y,Dong L,He Y,Deng Y,Tao Z

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri May 26 00:00:00 EDT 2023

Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing.

Signal transduction and targeted therapy

Liu W,Chen W,Xie M,Chen C,Shao Z,Zhang Y,Zhao H,Song Q,Hu H,Xing X,Cai X,Deng X,Li X,Wang P,Liu G,Xiong L,Lv X,Zhang Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Wed Jul 05 00:00:00 EDT 2023

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.

Frontiers in immunology

Drummer C,Saaoud F,Jhala NC,Cueto R,Sun Y,Xu K,Shao Y,Lu Y,Shen H,Yang L,Zhou Y,Yu J,Wu S,Snyder NW,Hu W,Zhuo J',Zhong Y,Jiang X,Wang H,Yang X

25-2061-82 was used in Flow cytometry/Cell sorting to provide novel insights on the roles of the caspase-11-GSDMD pathway in promoting hepatic macrophage inflammation and pyroptosis and novel targets for future therapeutic interventions involving the transition of NAFLD to NASH, hyperlipidemia, type II diabetes, metabolic syndrome, metabolically healthy obesity, atherosclerotic cardiovascular diseases, autoimmune diseases, liver transplantation, and hepatic cancers.

Tue Feb 14 00:00:00 EST 2023

Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.

Veterinary research

Feng L,Luo G,Li Y,Zhang C,Liu Y,Liu Y,Chen H,He D,Zhu Y,Gan L

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Tue Mar 14 00:00:00 EDT 2023

Macrophage Reprogramming via the Modulation of Unfolded Protein Response with siRNA-Loaded Magnetic Nanoparticles in a TAM-like Experimental Model.

Pharmaceutics

D'Urso A,Oltolina F,Borsotti C,Prat M,Colangelo D,Follenzi A

25-2061-82 was used in Flow cytometry/Cell sorting to provide a novel strategy for the development of new tumor immunotherapies in vivo.

Mon Jun 12 00:00:00 EDT 2023

BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization.

NPJ Regenerative medicine

Wang J,Xue Y,Wang Y,Liu C,Hu S,Zhao H,Gu Q,Yang H,Huang L,Zhou X,Shi Q

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu Feb 09 00:00:00 EST 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

L-norvaline affects the proliferation of breast cancer cells based on the microbiome and metabolome analysis.

Journal of applied microbiology

Zhu Q,Zai H,Zhang K,Zhang X,Luo N,Li X,Hu Y,Wu Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2022

G9a promotes inflammation in Streptococcus pneumoniae induced pneumonia mice by stimulating M1 macrophage polarization and H3K9me2 methylation in FOXP1 promoter region.

Annals of translational medicine

Li Y,Li G,Zhang L,Li Y,Zhao Z

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2022

Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.

Cancer immunology research

Wu Q,Huang Q,Jiang Y,Sun F,Liang B,Wang J,Hu X,Sun M,Ma Z,Shi Y,Liang Y,Tan Y,Zeng D,Yao F,Xu X,Yao Z,Li S,Rong X,Huang N,Sun L,Liao W,Shi M

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Tue Feb 01 00:00:00 EST 2022

Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy.

JCI insight

Howard ZM,Gomatam CK,Rabolli CP,Lowe J,Piepho AB,Bansal SS,Accornero F,Rafael-Fortney JA

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Oct 10 00:00:00 EDT 2022

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.

Journal of nanobiotechnology

Li K,Yan G,Huang H,Zheng M,Ma K,Cui X,Lu D,Zheng L,Zhu B,Cheng J,Zhao J

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu Jan 20 00:00:00 EST 2022

TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.

Biology

Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu Nov 03 00:00:00 EDT 2022

EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis.

Cell death & disease

Zhang X,Chen C,Ling C,Luo S,Xiong Z,Liu X,Liao C,Xie P,Liu Y,Zhang L,Chen Z,Liu Z,Tang J

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Nov 07 00:00:00 EST 2022

Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.

International journal of biological sciences

Qian Z,Chen H,Xia M,Chang J,Li X,Ye S,Wu S,Jiang S,Bao J,Wang B,Kong R,Zhang S,Zheng S,Cao X,Hong X

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri Apr 15 00:00:00 EDT 2022

Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization.

Stem cell research & therapy

Dong B,Wang C,Zhang J,Zhang J,Gu Y,Guo X,Zuo X,Pan H,Hsu AC,Wang G,Wang F

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Wed Mar 24 00:00:00 EDT 2021

Hyperoside Suppresses Renal Inflammation by Regulating Macrophage Polarization in Mice With Type 2 Diabetes Mellitus.

Frontiers in immunology

Liu J,Zhang Y,Sheng H,Liang C,Liu H,Moran Guerrero JA,Lu Z,Mao W,Dai Z,Liu X,Zhang L

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu Feb 10 00:00:00 EST 2022

Hyperoside Suppresses Renal Inflammation by Regulating Macrophage Polarization in Mice With Type 2 Diabetes Mellitus.

Frontiers in immunology

Liu J,Zhang Y,Sheng H,Liang C,Liu H,Moran Guerrero JA,Lu Z,Mao W,Dai Z,Liu X,Zhang L

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu Feb 10 00:00:00 EST 2022

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

Cells

Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Nov 15 00:00:00 EST 2021

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

Cells

Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Nov 15 00:00:00 EST 2021

Azithromycin alleviates systemic lupus erythematosus via the promotion of M2 polarisation in lupus mice.

Cell death discovery

Wang J,Chen Q,Zhang Z,Wang S,Wang Y,Xiang M,Liang J,Xu J

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri Apr 16 00:00:00 EDT 2021

Resolving macrophage polarization through distinct Ca²⁺ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.

iScience

Nascimento Da Conceicao V,Sun Y,Ramachandran K,Chauhan A,Raveendran A,Venkatesan M,DeKumar B,Maity S,Vishnu N,Kotsakis GA,Worley PF,Gill DL,Mishra BB,Madesh M,Singh BB

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri Nov 19 00:00:00 EST 2021

Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.

Frontiers in pharmacology

Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Sat Apr 02 00:00:00 EDT 2022

Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.

Stem cell research & therapy

Wang F,Kong L,Wang W,Shi L,Wang M,Chai Y,Xu J,Kang Q

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu May 13 00:00:00 EDT 2021

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway.

Frontiers in immunology

Kong F,Sun K,Zhu J,Li F,Lin F,Sun X,Luo X,Ren C,Lu L,Zhao S,Sun J,Wang Y,Shi J

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Nov 01 00:00:00 EDT 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice.

Communications biology

Song L,Chang R,Sun X,Lu L,Gao H,Lu H,Lin R,Xu X,Liu Z,Zhan L

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.

Experimental & molecular medicine

Lee YS,Song SJ,Hong HK,Oh BY,Lee WY,Cho YB

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn's Disease.

Journal of Crohn's & colitis

Gong W,Zheng T,Guo K,Fang M,Xie H,Li W,Tang Q,Hong Z,Ren H,Gu G,Wang G,Wu X,Zhao Y,Ren J

25-2061 was used in Flow cytometry/Cell sorting to show that Mincle signaling is significantly elevated in active human CD and experimental colitis, and macrophages are the principal leukocyte subset that up-regulate Mincle signaling.

Wed Dec 02 00:00:00 EST 2020

Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.

Journal of cellular and molecular medicine

Wang Y,Han B,Wang Y,Wang C,Zhang H,Xue J,Wang X,Niu T,Niu Z,Chen Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.

Nature communications

Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Jun 22 00:00:00 EDT 2020

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.

Journal of neuroinflammation

Kong FQ,Zhao SJ,Sun P,Liu H,Jie J,Xu T,Xu AD,Yang YQ,Zhu Y,Chen J,Zhou Z,Qian DF,Gu CJ,Chen Q,Yin GY,Zhang HW,Fan J

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Mon Feb 17 00:00:00 EST 2020

N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.

Nature communications

Lee JY,Han SH,Park MH,Song IS,Choi MK,Yu E,Park CM,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS

25-2061 was used in Flow cytometry/Cell sorting to identify a role of N-AS in the dysfunction of microglia in AD.

Tue May 12 00:00:00 EDT 2020

Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

CNS neuroscience & therapeutics

Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.

Journal for immunotherapy of cancer

Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1.

MicrobiologyOpen

Fultz R,Engevik MA,Shi Z,Hall A,Herrmann B,Ganesh BP,Major A,Haag A,Mori-Akiyama Y,Versalovic J

25-2061-82 was used in Flow Cytometry to propose histamine H2 receptor signaling is required for effective phagocytosis by regulating the process of autophagy and scavenger receptor MSR1 abundance in macrophages.

Tue Oct 01 00:00:00 EDT 2019

Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype.

Frontiers in pharmacology

Guo M,Xiao J,Sheng X,Zhang X,Tie Y,Wang L,Zhao L,Ji X

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone.

Journal of neuroinflammation

Yin X,Feng L,Ma D,Yin P,Wang X,Hou S,Hao Y,Zhang J,Xin M,Feng J

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Tue Mar 27 00:00:00 EDT 2018

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.

Oncotarget

Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P

25-2061 was used in Flow cytometry/Cell sorting to evaluate the role played by BNIP3 in modulating the interface between B16-F10 melanoma cells and immune cells.

Tue Apr 03 00:00:00 EDT 2018

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.

Scientific reports

Gao S,Li C,Zhu Y,Wang Y,Sui A,Zhong Y,Xie B,Shen X

Published figure using CD206 (MMR) monoclonal antibody (Product # 25-2061-82) in Flow Cytometry

Fri Feb 17 00:00:00 EST 2017

Bioinformatics

Protein Aliases: CD206; Macrophage mannose receptor 1; MMR

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Gene Aliases: AW259686; CD206; MR; Mrc1

View more View less

UniProt ID: (Mouse) Q61830

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Entrez Gene ID: (Mouse) 17533

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Function(s)

receptor activity transmembrane signaling receptor activity mannose binding carbohydrate binding

Process(es)

endocytosis receptor-mediated endocytosis signal transduction cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-4

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD206 (MMR) Monoclonal Antibody (MR6F3), PE-Cyanine7, eBioscience™

CD206 (MMR) Antibody (25-2061-82) in Flow

Product Details

25-2061-82

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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