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Leinco Technologies
CD252 (OX40L) Monoclonal Antibody (RM164L), Functional Grade, In Vivo GOLD™
Product Details
C2336-100MG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
RM164L
Immunogen
Rat NRK-52E cell line transfected with mouse OX-40L gene
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.2-7.4
Contains
no preservative
Storage conditions
4°C short term, -80°C long term
Shipping conditions
Wet ice
Product Specific Information
Specificity: Clone RM134L recognizes an epitope on mouse CD252.
Endotoxin Level: <1.0 EU/mg as determined by the LAL method.
Purity: ≥95% monomer by analytical SEC and >95% by SDS Page.
Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles.
Target Information
The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: atherosclerosis 1; CD252; OX40 ligand; OX40L; tax-transcriptionally activated glycoprotein 1 ligand; Tumor necrosis factor ligand superfamily member 4
Gene Aliases: Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l; Tnfsf4; TXGP1; Txgp1l
UniProt ID: (Mouse) P43488
Entrez Gene ID: (Mouse) 22164
blood vessel development
cytokine production
defense response to nematode
acute inflammatory response
positive regulation of immune effector process
positive regulation of T cell cytokine production
regulation of adaptive immune response
positive regulation of type 2 immune response
positive regulation of immunoglobulin mediated immune response
inflammatory response
immune response
cholesterol metabolic process
response to virus
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-13 production
positive regulation of interleukin-2 production
positive regulation of interleukin-4 production
positive regulation of interleukin-6 production
memory T cell activation
T-helper 2 cell activation
response to nitrogen dioxide
cellular response to nitrogen dioxide
CD4-positive, alpha-beta T cell costimulation
T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of memory T cell differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
innate immune response
negative regulation of regulatory T cell differentiation
negative regulation of T-helper 1 cell differentiation
positive regulation of T-helper 2 cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of alpha-beta T cell proliferation
negative regulation of cytokine secretion
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
negative regulation of T cell apoptotic process
negative regulation of activation-induced cell death of T cells
cellular response to lipopolysaccharide
cellular response to prostaglandin E stimulus
chemokine (C-C motif) ligand 11 production
positive regulation of CD4-positive, alpha-beta T cell costimulation
positive regulation of T cell migration
positive regulation of T cell costimulation
positive regulation of memory T cell activation
positive regulation of T-helper 2 cell activation
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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