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Invitrogen
CD26 Recombinant Rabbit Monoclonal Antibody (JM11-42)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
CD26 Antibody (MA5-32643) in WB
Western Blot was performed using Anti-CD26 Recombinant Rabbit Monoclonal Antibody (JM11-42) (Product # MA5-32643) and a 120 kDa band corresponding to Dipeptidyl peptidase 4 was observed across all the tested cell lines and tissues, except Jurkat, Jurkat+ Protein Transport Inhibitor Cocktail, K-562 and Mouse Colon. Whole cell extracts (30 µg lysate) of Hep G2 (Lane 1), Hep G2 (Protein Transport Inhibitor Cocktail (500X), 1X, 4 hours) (Lane 2), Caco-2 (Lane 3), Jurkat (Lane 4), Jurkat (Protein Transport Inhibitor Cocktail (500X), 1X, 4 hours... View More
Product Details
MA5-32643
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM11-42
Immunogen
Synthetic peptide within Human CD26 aa 701-747
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809920
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADABP; ADCP-2; Adenosine deaminase complexing protein 2; Bile canaliculus domain-specific membrane glycoprotein; CD26; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidyl-peptidase 4; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP IV; DPP-IV; GP110 glycoprotein; T-cell activation antigen CD26; THAM; Thymocyte-activating molecule; TP103
Gene Aliases: ADABP; ADCP2; CD26; Dpp-4; DPP4; DPPIV; THAM; TP103
UniProt ID: (Human) P27487, (Mouse) P28843, (Rat) P14740
Entrez Gene ID: (Human) 1803, (Mouse) 13482, (Rat) 25253
virus receptor activity
protease binding
serine-type endopeptidase activity
receptor binding
protein binding
serine-type peptidase activity
dipeptidyl-peptidase activity
identical protein binding
protein homodimerization activity
aminopeptidase activity
collagen binding
peptidase activity
hydrolase activity
peptide binding
serine protease
behavioral fear response
response to hypoxia
proteolysis
positive regulation of cell proliferation
negative regulation of extracellular matrix disassembly
T cell costimulation
regulation of cell-cell adhesion mediated by integrin
locomotory exploration behavior
psychomotor behavior
T cell activation
endothelial cell migration
viral entry into host cell
regulation of T cell mediated immunity
cell adhesion
establishment of localization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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