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Product Details
MA5-38151
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC2119
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-129 of human TWEAKR/Fn14/CD266 (Q9NP84)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898069
Product Specific Information
Positive Samples: HepG2, PC-3
Immunogen sequence: MDCASCRARP HSDFCLGCAA APPAPFRLLW PILGGALSLT FVLGLLSGFL VWRRCRRREK FTTPIEETGG EGCPAVALIQ
Target Information
TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD266; FGF-inducible 14; fibroblast growth factor regulated protein 2; Fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; Tweak-receptor; TweakR; type I transmembrane protein Fn14
Gene Aliases: AI255180; C87282; CD266; Fgfrp2; FN14; HPIP; TNFRSF12A; TWEAK-R; TWEAKR
UniProt ID: (Human) Q9NP84, (Mouse) Q9CR75
Entrez Gene ID: (Human) 51330, (Mouse) 27279
angiogenesis
substrate-dependent cell migration, cell attachment to substrate
tumor necrosis factor-mediated signaling pathway
positive regulation of apoptotic process
regulation of angiogenesis
positive regulation of axon extension
regulation of wound healing
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
apoptotic process
cell adhesion
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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