Invitrogen

CD282 (TLR2) Monoclonal Antibody (TL2.1), PE, eBioscience™

CD282 (TLR2) Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 9

CD282 (TLR2) Antibody (12-9922-42) in Flow

Staining of normal human peripheral blood cells with 2 µg of Mouse IgG2a K Isotype Control PE (Product # 12-4724-81) (open histogram) or Anti-Human CD282 (TLR2) PE (filled histogram). Cells in the monocyte gate were used for analysis.

Product Image Gallery

Product Details

12-9922-42

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

5 µL (1 µg)/test

View 36 publications 36 publications

Functional Assay (Functional)

View 6 publications 6 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a, kappa

Recommended Isotype Control

Mouse IgG2a kappa Isotype Control (eBM2a), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

TL2.1

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

5 µL/Test

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10667887

Product Specific Information

Description: The TL2.1 monoclonal antibody reacts with human Toll-like receptor 2 (TLR2). To date, at least ten members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed by peripheral blood monocytes and is responsible for distinguishing different pathogens. TL2.1, a blocking antibody, has been used to study the role of TLR-2 as a pattern recognition receptor in microbial lipoprotein/lipopeptide induced cytokine production from human peripheral blood mononuclear cells. TL2.1 has been reported to immunoprecipitate human TLR2 (~90 kDa) from PBMC and HMEC.

Applications Reported: The TL2.1 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This TL2.1 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model.

Particle and fibre toxicology

Bredeck G,Dobner J,Stahlmecke B,Fomba KW,Herrmann H,Rossi A,Schins RPF

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Fri Oct 20 00:00:00 EDT 2023

Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis.

Frontiers in immunology

Carneiro PP,Dórea AS,Oliveira WN,Guimarães LH,Brodskyn C,Carvalho EM,Bacellar O

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Mon Dec 13 00:00:00 EST 2021

Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis.

Frontiers in immunology

Carneiro PP,Dórea AS,Oliveira WN,Guimarães LH,Brodskyn C,Carvalho EM,Bacellar O

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Mon Dec 13 00:00:00 EST 2021

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis.

Nature communications

Aguilar-Briseño JA,Upasani V,Ellen BMT,Moser J,Pauzuolis M,Ruiz-Silva M,Heng S,Laurent D,Choeung R,Dussart P,Cantaert T,Smit JM,Rodenhuis-Zybert IA

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Tue Jun 23 00:00:00 EDT 2020

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis.

Nature communications

Aguilar-Briseño JA,Upasani V,Ellen BMT,Moser J,Pauzuolis M,Ruiz-Silva M,Heng S,Laurent D,Choeung R,Dussart P,Cantaert T,Smit JM,Rodenhuis-Zybert IA

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Tue Jun 23 00:00:00 EDT 2020

Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway.

Cells

Haake K,Neehus AL,Buchegger T,Kühnel MP,Blank P,Philipp F,Oleaga-Quintas C,Schulz A,Grimley M,Goethe R,Jonigk D,Kalinke U,Boisson-Dupuis S,Casanova JL,Bustamante J,Lachmann N

12-9922 was used in Flow cytometry/Cell sorting to report a disease modeling platform to study the role of macrophages in patients with inborn errors of IFN-γ immunity.

Wed Feb 19 00:00:00 EST 2020

Activation of the Toll‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro.

Oncology reports

Chen Y,Huang Z,Chen X,Ye H

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

Dietary Toll-Like Receptor Stimulants Promote Hepatic Inflammation and Impair Reverse Cholesterol Transport in Mice via Macrophage-Dependent Interleukin-1 Production.

Frontiers in immunology

Faraj TA,Stover C,Erridge C

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils.

Molecular medicine reports

Wu B,Wang L,Jiang L,Dong L,Xu F,Lu Y,Jin J,Wang Z,Liang G,Shan X

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.

PloS one

Graustein AD,Misch EA,Musvosvi M,Shey M,Shah JA,Seshadri C,Ajuogu A,Bowman K,Mulenga H,Veldsman A,Hanekom WA,Hatherill M,Scriba TJ,Hawn TR

Published figure using CD282 (TLR2) monoclonal antibody (Product # 12-9922-42) in Flow Cytometry

Tue May 07 00:00:00 EDT 2019

High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages.

Scientific reports

Inoue M,Niki M,Ozeki Y,Nagi S,Chadeka EA,Yamaguchi T,Osada-Oka M,Ono K,Oda T,Mwende F,Kaneko Y,Matsumoto M,Kaneko S,Ichinose Y,Njenga SM,Hamano S,Matsumoto S

12-9922 was used in Flow cytometry/Cell sorting to investigate the role of high-density lipoprotein (HDL) in mycobacteria-infected macrophages, and demonstrate that HDL suppresses the production of pro-infammatory cytokines.

Mon Apr 30 00:00:00 EDT 2018

Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children.

Frontiers in immunology

Siebert JN,Hamann L,Verolet CM,Gameiro C,Grillet S,Siegrist CA,Posfay-Barbe KM

12-9922 was used in Flow cytometry/Cell sorting to asses whether a defect somewhere along this toll-like receptor signally pathways increases susceptibility to recurrent pneumococcal low respiratory tract infections.

Mon Sep 16 00:00:00 EDT 2019

Early detection of neonatal group B streptococcus sepsis and the possible diagnostic utility of IL-6, IL-8, and CD11b in a human umbilical cord blood in vitro model.

Infection and drug resistance

Nakstad B,Sonerud T,Solevåg AL

12-9922 was used in Flow cytometry/Cell sorting to identify biomarkers with high sensitivity and specificity in an early stage of group B streptococcus infection.

Fri Jul 29 00:00:00 EDT 2016

Early detection of neonatal group B streptococcus sepsis and the possible diagnostic utility of IL-6, IL-8, and CD11b in a human umbilical cord blood in vitro model.

Infection and drug resistance

Nakstad B,Sonerud T,Solevåg AL

12-9922 was used in Flow cytometry/Cell sorting to identify biomarkers with high sensitivity and specificity in an early stage of group B streptococcus infection.

Fri Jul 29 00:00:00 EDT 2016

Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.

Immunology

Swindle EJ,Brown JM,Rådinger M,DeLeo FR,Metcalfe DD

12-9922 was used in Flow cytometry/Cell sorting to investigate the effect of interferon-γ on the biological responses of human mast cells to Staphylococcus aureus.

Sun Nov 01 00:00:00 EDT 2015

In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Arthritis research & therapy

Conrad K,Wu P,Sieper J,Syrbe U

12-9922 was used in Flow cytometry/Cell sorting to demonstrate in vivo pre-activation of monocytes in axial spondyloarthritis patients indicated by enhanced cytokine production by monocytes.

Thu Jul 16 00:00:00 EDT 2015

Interactions between alveolar epithelial cells and neutrophils under pro-inflammatory conditions.

European clinical respiratory journal

von Schéele I,Larsson K,Palmberg L

12-9922 was used in Flow cytometry/Cell sorting to investigate communication between cells constituting the first line of defence under infection from chronic obstructive pulmonary disease.

Wed Nov 11 00:00:00 EST 2015

The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.

BMC immunology

Ten Oever J,Kox M,van de Veerdonk FL,Mothapo KM,Slavcovici A,Jansen TL,Tweehuysen L,Giamarellos-Bourboulis EJ,Schneeberger PM,Wever PC,Stoffels M,Simon A,van der Meer JW,Johnson MD,Kullberg BJ,Pickkers P,Pachot A,Joosten LA,Netea MG

12-9922 was used in Flow cytometry/Cell sorting to suggest the possibility to use sTLRs as a diagnostic tool for inflammatory conditions.

Wed Nov 19 00:00:00 EST 2014

Biologically active polymers from spontaneous carotenoid oxidation: a new frontier in carotenoid activity.

PloS one

Johnston JB,Nickerson JG,Daroszewski J,Mogg TJ,Burton GW

12-9922 was used in Flow cytometry/Cell sorting to study carotenoid activity via biologically active polymers from spontaneous carotenoid oxidation.

Thu Jun 25 00:00:00 EDT 2015

Development of monocyte Toll-like receptor 2 and Toll-like receptor 4 in preterm newborns during the first few months of life.

Pediatric research

Shen CM,Lin SC,Niu DM,Kou YR

12-9922 was used in Flow Cytometry to study the development of Toll-like receptor 2 and Toll-like receptor 4 at birth in preterm newborns and during the first few months of life.

Wed May 01 00:00:00 EDT 2013

Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation.

Retrovirology

Novis CL,Archin NM,Buzon MJ,Verdin E,Round JL,Lichterfeld M,Margolis DM,Planelles V,Bosque A

12-9922 was used in Flow cytometry/Cell sorting to evaluate the ability of toll-like receptor ligands to reactivate latent HIV-1 within central memory CD4+ T cells.

Thu Oct 24 00:00:00 EDT 2013

Experimental gerontology

Boyd AR,Shivshankar P,Jiang S,Berton MT,Orihuela CJ

12-9922 was used in Flow cytometry/Cell sorting to investigate the extent of the impact of age-related deficiencies in Toll-like receptor function.

Sun Jul 01 00:00:00 EDT 2012

Toll-like receptor expression in smokers with and without COPD.

Respiratory medicine

von Scheele I,Larsson K,Dahlén B,Billing B,Skedinger M,Lantz AS,Palmberg L

12-9922 was used in Flow cytometry/Cell sorting to study Toll-like receptor expression in smokers with and without chronic obstructive pulmonary disease.

Mon Aug 01 00:00:00 EDT 2011

Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract.

PloS one

Zhou J,Eksioglu EA,Fortenbery NR,Chen X,Wang H,Epling-Burnette PK,Djeu JY,Wei S

12-9922 was used in Flow cytometry/Cell sorting to elucidate the effects of cigarette smoke on human bone marrow haematopoiesis and characterise the inflammatory response.

Thu Dec 01 00:00:00 EST 2011

Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands.

Journal of immunology (Baltimore, Md. : 1950)

Oberg HH,Ly TT,Ussat S,Meyer T,Kabelitz D,Wesch D

12-9922 was used in Flow cytometry/Cell sorting to investigate whether TLR2 ligands can abolish human regulatory T cell suppressive capacity.

Sat May 01 00:00:00 EDT 2010

Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo.

Pediatric research

Zhang JP,Yang Y,Levy O,Chen C

12-9922 was used in Flow cytometry/Cell sorting to suggest key roles for innate immune pathways in neonatal responses to G+ and G- bacterial infection.

Wed Dec 01 00:00:00 EST 2010

Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut.

Gastroenterology

Caruso R,Sarra M,Stolfi C,Rizzo A,Fina D,Fantini MC,Pallone F,MacDonald TT,Monteleone G

12-9922 was used in Flow cytometry/Cell sorting to demonstrate that IL-25 inhibits CD14+ cell-derived cytokines and experimental colitis, so could be a treatment for Crohn's disease and ulcerative colitis.

Mon Jun 01 00:00:00 EDT 2009

The role of infection in the development of non-valvular atrial fibrillation: up-regulation of Toll-like receptor 2 expression levels on monocytes.

Journal of cardiology

Ichiki H,Orihara K,Hamasaki S,Ishida S,Oketani N,Iriki Y,Ninomiya Y,Okui H,Kuwahata S,Fujita S,Matsushita T,Yoshifuku S,Oba R,Hirai H,Nagata K,Tei C

12-9922 was used in Flow cytometry/Cell sorting to explore whether expression of TLR2 levels are up-regulated in patients with non-valvular atrial fibrillation.

Sun Feb 01 00:00:00 EST 2009

Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis.

Critical care (London, England)

Martins PS,Brunialti MK,Martos LS,Machado FR,Assunçao MS,Blecher S,Salomao R

12-9922 was used in Flow cytometry/Cell sorting to demonstrate that expression of surface receptors on neutrophils might be modulated across different severities of sepsis depending on the receptor.

Mon Jun 23 00:00:00 EDT 2008

The Journal of investigative dermatology

Mandron M,Ariès MF,Boralevi F,Martin H,Charveron M,Taieb A,Davrinche C

Tue Apr 01 00:00:00 EDT 2008

Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease.

Rheumatology (Oxford, England)

Do JE,Kwon SY,Park S,Lee ES

Sun Jun 01 00:00:00 EDT 2008

Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity.

Journal of leukocyte biology

Peiser M,Koeck J,Kirschning CJ,Wittig B,Wanner R

12-9922 was used in Flow cytometry/Cell sorting to analyse the Toll-like receptor (TLR) phenotype of epidermal Langerhans cells treated with various TLR agonists.

Thu May 01 00:00:00 EDT 2008

Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry.

Veterinary immunology and immunopathology

Burgener IA,Jungi TW

Tue Jul 15 00:00:00 EDT 2008

Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells.

Respiratory research

Issa R,Sorrentino R,Sukkar MB,Sriskandan S,Chung KF,Mitchell JA

12-9922 was used in Flow cytometry/Cell sorting to show that Gram-positive or Gram-negative bacteria cause human airway smooth muscle cells to release the neutrophil selective chemokine CXCL-8.

Tue Apr 01 00:00:00 EDT 2008

Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling.

The Journal of infectious diseases

Sadeghi K,Berger A,Langgartner M,Prusa AR,Hayde M,Herkner K,Pollak A,Spittler A,Forster-Waldl E

12-9922 was used in Flow cytometry/Cell sorting to show that the reduced functional response to components of the bacterial cell wall might predispose premature newborns to bacterial infection.

Mon Jan 15 00:00:00 EST 2007

Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis.

Investigative ophthalmology & visual science

Chang JH,Hampartzoumian T,Everett B,Lloyd A,McCluskey PJ,Wakefield D

12-9922 was used in Flow cytometry/Cell sorting to suggest that microbial triggers and TLRs play a role in the pathogenesis of acute anterior uveitis.

Sun Apr 01 00:00:00 EDT 2007

Toll-like receptor 3 (TLR3): a new marker of canine monocytes-derived dendritic cells (cMo-DC).

Veterinary immunology and immunopathology

Bonnefont-Rebeix C,Marchal T,Bernaud J,Pin JJ,Leroux C,Lebecque S,Chabanne L,Rigal D

Sun Jul 15 00:00:00 EDT 2007

Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle.

The Journal of allergy and clinical immunology

Sukkar MB,Xie S,Khorasani NM,Kon OM,Stanbridge R,Issa R,Chung KF

12-9922 was used in Flow cytometry/Cell sorting to determine the effects of cytokines, TLR ligands, and corticosteroids on TLR expression in human airway smooth muscle cells.

Fri Sep 01 00:00:00 EDT 2006

Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Feldmann G,Nischalke HD,Nattermann J,Banas B,Berg T,Teschendorf C,Schmiegel W,Dührsen U,Halangk J,Iwan A,Sauerbruch T,Caselmann WH,Spengler U

12-9922 was used in Functional assays to study whether recognition of hepatitis C virus proteins by pattern recognition receptors is involved in the pathogenesis of HCV-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma.

Tue Aug 01 00:00:00 EDT 2006

Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease.

Respiratory research

Pons J,Sauleda J,Regueiro V,Santos C,López M,Ferrer J,Agustí AG,Bengoechea JA

12-9922 was used in Flow cytometry/Cell sorting to reveal abnormalities in TLRs expression in chronic obstructive pulmonary disease patients and highlight its potential relationship with systemic inflammation.

Mon Apr 10 00:00:00 EDT 2006

Neonatal immune responses to microbial stimuli: is there an influence of maternal allergy?

The Journal of allergy and clinical immunology

Amoudruz P,Holmlund U,Malmström V,Trollmo C,Bremme K,Scheynius A,Sverremark-Ekström E

12-9922 was used in Flow cytometry/Cell sorting to suggest that cord blood monocytes and cord blood mononuclear blood cell immune responses are influenced by maternal allergy.

Wed Jun 01 00:00:00 EDT 2005

Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

Cook EB,Stahl JL,Esnault S,Barney NP,Graziano FM

Fri Apr 01 00:00:00 EST 2005

Peptidoglycan of Staphylococcus aureus upregulates monocyte expression of CD14, Toll-like receptor 2 (TLR2), and TLR4 in human blood: possible implications for priming of lipopolysaccharide signaling.

Infection and immunity

Hadley JS,Wang JE,Foster SJ,Thiemermann C,Hinds CJ

12-9922 was used in Flow cytometry/Cell sorting to show that TLR2 and TLR4 upregulation precedes the synergistic effects of lipopolysaccharide and peptidoglycan on cytokine release.

Tue Nov 01 00:00:00 EST 2005

Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells.

American journal of respiratory cell and molecular biology

Homma T,Kato A,Hashimoto N,Batchelor J,Yoshikawa M,Imai S,Wakiguchi H,Saito H,Matsumoto K

12-9922 was used in Flow cytometry/Cell sorting to investigate the involvement of TLR family molecules in corticosteroid treatment.

Fri Oct 01 00:00:00 EDT 2004

Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium.

Journal of immunology (Baltimore, Md. : 1950)

Ueta M,Nochi T,Jang MH,Park EJ,Igarashi O,Hino A,Kawasaki S,Shikina T,Hiroi T,Kinoshita S,Kiyono H

Wed Sep 01 00:00:00 EDT 2004

Membrane-anchored CD14 is important for induction of interleukin-8 by lipopolysaccharide and peptidoglycan in uroepithelial cells.

Clinical and diagnostic laboratory immunology

Shimizu T,Yokota S,Takahashi S,Kunishima Y,Takeyama K,Masumori N,Takahashi A,Matsukawa M,Itoh N,Tsukamoto T,Fujii N

12-9922 was used in Flow cytometry/Cell sorting to identify factors promoting IL-8 induction in bladder epithelial cells in response to bacterial components.

Wed Sep 01 00:00:00 EDT 2004

Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis.

Arthritis and rheumatism

Iwahashi M,Yamamura M,Aita T,Okamoto A,Ueno A,Ogawa N,Akashi S,Miyake K,Godowski PJ,Makino H

Sat May 01 00:00:00 EDT 2004

The urokinase receptor can be induced by Borrelia burgdorferi through receptors of the innate immune system.

Infection and immunity

Coleman JL,Benach JL

Wed Oct 01 00:00:00 EDT 2003

Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung.

Histochemistry and cell biology

Droemann D,Goldmann T,Branscheid D,Clark R,Dalhoff K,Zabel P,Vollmer E

Sat Feb 01 00:00:00 EST 2003

Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis.

Oral microbiology and immunology

Mori Y,Yoshimura A,Ukai T,Lien E,Espevik T,Hara Y

Sat Feb 01 00:00:00 EST 2003

Bioinformatics

Protein Aliases: CD282; TLR-2; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4

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Gene Aliases: CD282; TIL4; TLR2

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UniProt ID: (Human) O60603

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Entrez Gene ID: (Human) 7097

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Function(s)

lipopolysaccharide binding lipopolysaccharide receptor activity receptor activity transmembrane signaling receptor activity protein binding signaling pattern recognition receptor activity Toll-like receptor binding triacyl lipopeptide binding peptidoglycan binding protein heterodimerization activity

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD282 (TLR2) Monoclonal Antibody (TL2.1), PE, eBioscience™

CD282 (TLR2) Antibody (12-9922-42) in Flow

Product Details

12-9922-42

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Functional Assay (Functional)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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