Product References
Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts.
Cell reports
Di Nardo A,Chang YL,Alimohammadi S,Masuda-Kuroki K,Wang Z,Sriram K,Insel PA
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Tue May 30 00:00:00 EDT 2023
Mechanical Compression by Simulating Orthodontic Tooth Movement in an In Vitro Model Modulates Phosphorylation of AKT and MAPKs via TLR4 in Human Periodontal Ligament Cells.
International journal of molecular sciences
Roth CE,Craveiro RB,Niederau C,Malyaran H,Neuss S,Jankowski J,Wolf M
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Fri Jul 22 00:00:00 EDT 2022
Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88.
Innate immunity
Yang Y,Hu Y,Zhou Y,Liang T,Tang H,Ju H,Shi Q,Fang H
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Western Blot
Sun Aug 01 00:00:00 EDT 2021
Helicobacter pylori Neutrophil-Activating Protein Directly Interacts with and Activates Toll-like Receptor 2 to Induce the Secretion of Interleukin-8 from Neutrophils and ATRA-Induced Differentiated HL-60 Cells.
International journal of molecular sciences
Wen SH,Hong ZW,Chen CC,Chang HW,Fu HW
16-9917-82 was used in Neutralization to conclude that HP-NAP directly interacts with and activates TLR2 to induce IL-8 secretion in neutrophils and ATRA-induced differentiated HL-60 cells.
Tue Oct 26 00:00:00 EDT 2021
Helicobacter pylori Neutrophil-Activating Protein Directly Interacts with and Activates Toll-like Receptor 2 to Induce the Secretion of Interleukin-8 from Neutrophils and ATRA-Induced Differentiated HL-60 Cells.
International journal of molecular sciences
Wen SH,Hong ZW,Chen CC,Chang HW,Fu HW
16-9917-82 was used in Neutralization to conclude that HP-NAP directly interacts with and activates TLR2 to induce IL-8 secretion in neutrophils and ATRA-induced differentiated HL-60 cells.
Tue Oct 26 00:00:00 EDT 2021
Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1.
Blood advances
Quirino-Teixeira AC,Rozini SV,Barbosa-Lima G,Coelho DR,Carneiro PH,Mohana-Borges R,Bozza PT,Hottz ED
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Tue May 12 00:00:00 EDT 2020
Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1.
Blood advances
Quirino-Teixeira AC,Rozini SV,Barbosa-Lima G,Coelho DR,Carneiro PH,Mohana-Borges R,Bozza PT,Hottz ED
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Tue May 12 00:00:00 EDT 2020
Grindelia squarrosa Extract and Grindelic Acid Modulate Pro-inflammatory Functions of Respiratory Epithelium and Human Macrophages.
Frontiers in pharmacology
Gierlikowska B,Filipek A,Gierlikowski W,Kania D,Stefańska J,Demkow U,Kiss AK
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Sat Feb 06 00:00:00 EST 2021
Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells.
International journal of molecular medicine
Suzuki K,Ohkuma M,Nagaoka I
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Toll‑Like receptor 4 promotes the phosphorylation of CRMP2 via the activation of Rho‑kinase in MCAO rats.
Molecular medicine reports
Li XB,Ding MX,Ding CL,Li LL,Feng J,Yu XJ
Sun Jul 01 00:00:00 EDT 2018
n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils.
Molecular medicine reports
Wu B,Wang L,Jiang L,Dong L,Xu F,Lu Y,Jin J,Wang Z,Liang G,Shan X
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Butyrate upregulates the TLR4 expression and the phosphorylation of MAPKs and NK-κB in colon cancer cell in vitro.
Oncology letters
Xiao T,Wu S,Yan C,Zhao C,Jin H,Yan N,Xu J,Wu Y,Li C,Shao Q,Xia S
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2018
Bushfire smoke is pro-inflammatory and suppresses macrophage phagocytic function.
Scientific reports
Hamon R,Tran HB,Roscioli E,Ween M,Jersmann H,Hodge S
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Fri Sep 07 00:00:00 EDT 2018
Altered Toll-like receptor expression and function in HPV-associated oropharyngeal carcinoma.
Oncotarget
Tobouti PL,Bolt R,Radhakrishnan R,de Sousa SCOM,Hunter KD
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Tue Jan 02 00:00:00 EST 2018
A low dose lipid infusion is sufficient to induce insulin resistance and a pro-inflammatory response in human subjects.
PloS one
Liang H,Lum H,Alvarez A,Garduno-Garcia JJ,Daniel BJ,Musi N
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Fri Jul 27 00:00:00 EDT 2018
Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue.
PLoS pathogens
Trugilho MRO,Hottz ED,Brunoro GVF,Teixeira-Ferreira A,Carvalho PC,Salazar GA,Zimmerman GA,Bozza FA,Bozza PT,Perales J
16-9917 was used in Neutralization experiments to compare the protein content of platelets in clinical samples from patients with dengue with platelets from healthy donors.
Mon May 01 00:00:00 EDT 2017
Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue.
PLoS pathogens
Trugilho MRO,Hottz ED,Brunoro GVF,Teixeira-Ferreira A,Carvalho PC,Salazar GA,Zimmerman GA,Bozza FA,Bozza PT,Perales J
16-9917 was used in Neutralization experiments to compare the protein content of platelets in clinical samples from patients with dengue with platelets from healthy donors.
Mon May 01 00:00:00 EDT 2017
Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells.
Scientific reports
Bi J,Koivisto L,Pang A,Li M,Jiang G,Aurora S,Wang Z,Owen GR,Dai J,Shen Y,Grenier D,Haapasalo M,Häkkinen L,Larjava H
16-9917 was used in Flow cytometry/Cell sorting to show that multispecies bacterial biofilms downregulate αvβ6 integrin levels, increasing production of pro-inflammatory cytokines in periodontal disease.
Fri Jun 30 00:00:00 EDT 2017
Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-κB pathway in human pulmonary epithelial A549 cells.
Oncology letters
Shi R,Wang Q,Ouyang Y,Wang Q,Xiong X
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Mon Feb 01 00:00:00 EST 2016
Comparative miRNA-Based Fingerprinting Reveals Biological Differences in Human Olfactory Mucosa- and Bone-Marrow-Derived Mesenchymal Stromal Cells.
Stem cell reports
Lindsay SL,Johnstone SA,McGrath MA,Mallinson D,Barnett SC
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Tue May 10 00:00:00 EDT 2016
Comparative miRNA-Based Fingerprinting Reveals Biological Differences in Human Olfactory Mucosa- and Bone-Marrow-Derived Mesenchymal Stromal Cells.
Stem cell reports
Lindsay SL,Johnstone SA,McGrath MA,Mallinson D,Barnett SC
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Tue May 10 00:00:00 EDT 2016
Lipopolysaccharide induces SBD-1 expression via the P38 MAPK signaling pathway in ovine oviduct epithelial cells.
Lipids in health and disease
Li Q,Bao F,Zhi D,Liu M,Yan Q,Zheng X,Ren L,Cong S,Li Y,Cao G
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Thu Aug 11 00:00:00 EDT 2016
Lipopolysaccharide induces SBD-1 expression via the P38 MAPK signaling pathway in ovine oviduct epithelial cells.
Lipids in health and disease
Li Q,Bao F,Zhi D,Liu M,Yan Q,Zheng X,Ren L,Cong S,Li Y,Cao G
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Thu Aug 11 00:00:00 EDT 2016
Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis.
Clinical and vaccine immunology : CVI
Rossi O,Caboni M,Negrea A,Necchi F,Alfini R,Micoli F,Saul A,MacLennan CA,Rondini S,Gerke C
16-9917 was used in Blocking experiments to investigate the differences between Salmonella enterica strains in terms of TLR activation by generalised modules for membrane antigens from lipid A mutants.
Fri Apr 01 00:00:00 EDT 2016
TLR4 Expression Is Associated with Left Ventricular Dysfunction in Patients Undergoing Coronary Artery Bypass Surgery.
PloS one
Avlas O,Bragg A,Fuks A,Nicholson JD,Farkash A,Porat E,Aravot D,Levy-Drummer RS,Cohen C,Shainberg A,Arad M,Hochhauser E
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunofluorescence
Fri Mar 04 00:00:00 EST 2016
TLR4 Expression Is Associated with Left Ventricular Dysfunction in Patients Undergoing Coronary Artery Bypass Surgery.
PloS one
Avlas O,Bragg A,Fuks A,Nicholson JD,Farkash A,Porat E,Aravot D,Levy-Drummer RS,Cohen C,Shainberg A,Arad M,Hochhauser E
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunofluorescence
Fri Mar 04 00:00:00 EST 2016
The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.
Science signaling
Liaunardy-Jopeace A,Bryant CE,Gay NJ
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunofluorescence
Tue Jul 29 00:00:00 EDT 2014
The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.
Science signaling
Liaunardy-Jopeace A,Bryant CE,Gay NJ
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunofluorescence
Tue Jul 29 00:00:00 EDT 2014
Biomechanical loading modulates proinflammatory and bone resorptive mediators in bacterial-stimulated PDL cells.
Mediators of inflammation
Nogueira AV,Nokhbehsaim M,Eick S,Bourauel C,Jäger A,Jepsen S,Rossa C,Deschner J,Cirelli JA
16-9917 was used in Blocking experiments to provide evidence that cyclic tensile strain (CTS) enhances bacterial-induced syntheses of molecules associated with inflammation and bone resorption by periodontal ligament cells.
Thu Feb 12 00:00:00 EST 2015
Biologically active polymers from spontaneous carotenoid oxidation: a new frontier in carotenoid activity.
PloS one
Johnston JB,Nickerson JG,Daroszewski J,Mogg TJ,Burton GW
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunocytochemistry
Thu Jun 25 00:00:00 EDT 2015
Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production.
Haematologica
Velegraki M,Papakonstanti E,Mavroudi I,Psyllaki M,Tsatsanis C,Oulas A,Iliopoulos I,Katonis P,Papadaki HA
16-9917 was used in Blocking experiments to investigate the involvement of toll-like receptors and their ligands in inflammation in the marrow of patients with myelodysplastic syndromes.
Thu Aug 01 00:00:00 EDT 2013
HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.
Journal of immunology (Baltimore, Md. : 1950)
Nazli A,Kafka JK,Ferreira VH,Anipindi V,Mueller K,Osborne BJ,Dizzell S,Chauvin S,Mian MF,Ouellet M,Tremblay MJ,Mossman KL,Ashkar AA,Kovacs C,Bowdish DM,Snider DP,Kaul R,Kaushic C
16-9917 was used in Neutralization experiments to provide a mechanism by which HIV-1 gp120 could initiate innate immune activation in the female reproductive tract during heterosexual transmission.
Tue Oct 15 00:00:00 EDT 2013
Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling.
The Journal of biological chemistry
Bretz NP,Ridinger J,Rupp AK,Rimbach K,Keller S,Rupp C,Marmé F,Umansky L,Umansky V,Eigenbrod T,Sammar M,Altevogt P
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Fri Dec 20 00:00:00 EST 2013
Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling.
The Journal of biological chemistry
Bretz NP,Ridinger J,Rupp AK,Rimbach K,Keller S,Rupp C,Marmé F,Umansky L,Umansky V,Eigenbrod T,Sammar M,Altevogt P
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Fri Dec 20 00:00:00 EST 2013
Monocytes from tuberculosis patients that exhibit cleaved caspase 9 and denaturalized cytochrome c are more susceptible to death mediated by Toll-like receptor 2.
Immunology
Chávez-Galán L,Sada-Ovalle I,Baez-Saldaña R,Chávez R,Lascurain R
16-9917-82 was used in Flow Cytometry to study the increased percentage of circulating monocytes in patients with tuberculosis in comparison to healthy controls.
Sun Apr 01 00:00:00 EDT 2012
Late repression of NF-κB activity by invasive but not non-invasive meningococcal isolates is required to display apoptosis of epithelial cells.
PLoS pathogens
Deghmane AE,El Kafsi H,Giorgini D,Abaza A,Taha MK
16-9917 was used in Neutralization experiments to show that only non-invasive meningococcal isolates are able to induce sustained NF-κB activity in infected epithelial cells.
Thu Dec 01 00:00:00 EST 2011
TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease.
The Journal of biological chemistry
Geraghty P,Dabo AJ,D'Armiento J
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunofluorescence
Fri Aug 26 00:00:00 EDT 2011
TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease.
The Journal of biological chemistry
Geraghty P,Dabo AJ,D'Armiento J
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunofluorescence
Fri Aug 26 00:00:00 EDT 2011
Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy.
Autophagy
Yuk JM,Shin DM,Song KS,Lim K,Kim KH,Lee SH,Kim JM,Lee JS,Paik TH,Kim JS,Jo EK
16-9917-82 was used in Flow cytometry/Cell sorting to suggest that BCG/CWS in combination with IR is a promising therapeutic strategy for enhancing radiation therapy in colon cancer cells through the induction of autophagy.
Fri Jan 01 00:00:00 EST 2010
Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation.
Proceedings of the National Academy of Sciences of the United States of America
Krüger B,Krick S,Dhillon N,Lerner SM,Ames S,Bromberg JS,Lin M,Walsh L,Vella J,Fischereder M,Krämer BK,Colvin RB,Heeger PS,Murphy BT,Schröppel B
16-9917 was used in Functional assays to study the role of Toll-like receptor 4 signalling in ischaemia and reperfusion injury following human kidney transplantation.
Tue Mar 03 00:00:00 EST 2009
Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo.
Atherosclerosis
Dasu MR,Riosvelasco AC,Jialal I
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Thu Jan 01 00:00:00 EST 2009
High-mobility group box 1 protein induces tissue factor expression in vascular endothelial cells via activation of NF-kappaB and Egr-1.
Thrombosis and haemostasis
Lv B,Wang H,Tang Y,Fan Z,Xiao X,Chen F
16-9917 was used in Blocking experiments to delineate the potential role of high-mobility group box 1 protein in the pathogenesis of atherothrombosis.
Sat Aug 01 00:00:00 EDT 2009
Aggregation and microparticle production through toll-like receptor 4 activation in platelets from recently menopausal women.
Journal of cardiovascular pharmacology
Hashimoto K,Jayachandran M,Owen WG,Miller VM
16-9917 was used in Blocking experiments to investigate whether the effects of TLR4 underlie the increased thrombotic and cardiovascular risk that comes with bacterial infection.
Wed Jul 01 00:00:00 EDT 2009
Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.
Infection and immunity
Schierloh P,Yokobori N,Alemán M,Landoni V,Geffner L,Musella RM,Castagnino J,Baldini M,Abbate E,de la Barrera SS,Sasiain MC
16-9917 was used in Blocking experiments to study how mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.
Thu Nov 01 00:00:00 EDT 2007
Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma.
Blood
Vermi W,Facchetti F,Riboldi E,Heine H,Scutera S,Stornello S,Ravarino D,Cappello P,Giovarelli M,Badolato R,Zucca M,Gentili F,Chilosi M,Doglioni C,Ponzi AN,Sozzani S,Musso T
16-9917 was used in Blocking experiments to suggest that the humoral immune response to B henselae initiates in the extrafollicular areas of infected lymph nodes and is regulated by DCs.
Sun Jan 15 00:00:00 EST 2006
Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4.
Microbes and infection
de Graaf R,Kloppenburg G,Kitslaar PJ,Bruggeman CA,Stassen F
Thu Jun 01 00:00:00 EDT 2006
The uptake of a Klebsiella pneumoniae capsule polysaccharide mutant triggers an inflammatory response by human airway epithelial cells.
Microbiology (Reading, England)
Regueiro V,Campos MA,Pons J,Albertí S,Bengoechea JA
16-9917 was used in Flow cytometry/Cell sorting to indicate that Klebsiella pneumoniae capsule polysaccharide internalization by airway epithelial cells could trigger activation of the innate immune system.
Wed Feb 01 00:00:00 EST 2006
Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors.
The Journal of investigative dermatology
Nagy I,Pivarcsi A,Koreck A,Széll M,Urbán E,Kemény L
16-9917 was used in Blocking experiments to suggest that Propionibacterium acnes modulates the antimicrobial peptide and chemokine expression of keratinocytes.
Sun May 01 00:00:00 EDT 2005
Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide.
Respiratory research
MacRedmond R,Greene C,Taggart CC,McElvaney N,O'Neill S
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Wed Oct 12 00:00:00 EDT 2005
Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide.
Respiratory research
MacRedmond R,Greene C,Taggart CC,McElvaney N,O'Neill S
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Wed Oct 12 00:00:00 EDT 2005
TLR9 is localized in the endoplasmic reticulum prior to stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Leifer CA,Kennedy MN,Mazzoni A,Lee C,Kruhlak MJ,Segal DM
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunofluorescence
Thu Jul 15 00:00:00 EDT 2004
Differential regulation of inflammatory cytokine secretion by human dendritic cells upon Chlamydia trachomatis infection.
Infection and immunity
Gervassi A,Alderson MR,Suchland R,Maisonneuve JF,Grabstein KH,Probst P
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Neutralization
Wed Dec 01 00:00:00 EST 2004
Expression and involvement of Toll-like receptors (TLR)2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis.
Medical science monitor : international medical journal of experimental and clinical research
Mirlashari MR,Lyberg T
Fri Aug 01 00:00:00 EDT 2003
Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts.
Infection and immunity
Tabeta K,Yamazaki K,Akashi S,Miyake K,Kumada H,Umemoto T,Yoshie H
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Immunocytochemistry
Thu Jun 01 00:00:00 EDT 2000
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
The Journal of experimental medicine
Shimazu R,Akashi S,Ogata H,Nagai Y,Fukudome K,Miyake K,Kimoto M
Published figure using CD284 (TLR4) monoclonal antibody (Product # 16-9917-82) in Flow Cytometry
Mon Jun 07 00:00:00 EDT 1999