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Product Details
BS-1100R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from mouse CD36, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adipocyte membrane protein; CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); cluster determinant 36; collagen type I receptor thrombospondin receptor; FAT; Fatty acid translocase; fatty acid transport protein; Glycoprotein IIIb; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; scavenger receptor class B, member 3; SR-B3; Thrombospondin receptor
Gene Aliases: BDPLT10; CD36; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
UniProt ID: (Human) P16671, (Mouse) Q08857
Entrez Gene ID: (Human) 948, (Rat) 29184, (Mouse) 12491
low-density lipoprotein receptor activity
protein binding
high-density lipoprotein particle binding
lipid binding
low-density lipoprotein particle binding
transforming growth factor beta binding
thrombospondin receptor activity
lipoteichoic acid receptor activity
lipoprotein particle binding
oleic acid binding
membrane trafficking regulatory protein
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cell-matrix adhesion
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
platelet degranulation
MyD88-dependent toll-like receptor signaling pathway
lipid metabolic process
receptor-mediated endocytosis
phagocytosis, recognition
immune response
cell adhesion
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
nitric oxide mediated signal transduction
blood coagulation
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol storage
lipid storage
cGMP-mediated signaling
positive regulation of blood coagulation
intestinal cholesterol absorption
cholesterol transport
receptor internalization
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
response to lipid
triglyceride transport
plasma lipoprotein particle clearance
low-density lipoprotein particle clearance
response to stilbenoid
toll-like receptor TLR6:TLR2 signaling pathway
lipoprotein transport
negative regulation of transcription factor import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
apoptotic cell clearance
negative regulation of growth of symbiont in host
long-chain fatty acid import
interleukin-1 beta secretion
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-positive bacterium
intestinal absorption
sensory perception of taste
low-density lipoprotein particle mediated signaling
positive regulation of phagocytosis, engulfment
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
cholesterol import
response to fatty acid
response to linoleic acid
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to low-density lipoprotein particle stimulus
cellular response to hydroperoxide
cellular response to diacyl bacterial lipopeptide
positive regulation of NLRP3 inflammasome complex assembly
amyloid fibril formation
regulation of removal of superoxide radicals
positive regulation of blood microparticle formation
positive regulation of reactive oxygen species metabolic process
regulation of energy homeostasis
long-chain fatty acid metabolic process
pattern recognition receptor signaling pathway
negative regulation of systemic arterial blood pressure
fatty acid metabolic process
triglyceride metabolic process
signal transduction
response to nutrient
response to mechanical stimulus
negative regulation of gene expression
response to activity
fatty acid transport
long-chain fatty acid transport
plasma membrane long-chain fatty acid transport
negative regulation of angiogenesis
fatty acid oxidation
response to estradiol
cellular response to insulin stimulus
response to drug
positive regulation of MAPK cascade
digestive tract development
positive regulation of cytokine secretion
response to growth hormone
cellular response to bacterial lipopeptide
transport
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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