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Product Details
MA5-29862
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
002
Immunogen
Recombinant Rat CD36/SCARB3 Protein (Gly30-Lys439)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2785679
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Rat CD36/SCARB3.
Target Information
CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adipocyte membrane protein; CD36 antigen (collagen type I receptor, thrombospondin receptor); collagen type I receptor thrombospondin receptor; fatty acid translocase; fatty acid transport protein; glycoprotein IIIb; GPIIIB; GPIV; PAS IV; PAS-4; platelet glycoprotein 4; platelet glycoprotein IV; SR-B3
Gene Aliases: Fat
Entrez Gene ID: (Rat) 29184
low-density lipoprotein receptor activity
protein binding
high-density lipoprotein particle binding
lipid binding
low-density lipoprotein particle binding
transforming growth factor beta binding
thrombospondin receptor activity
oleic acid binding
lipoteichoic acid receptor activity
lipoprotein particle binding
membrane trafficking regulatory protein
negative regulation of transcription from RNA polymerase II promoter
long-chain fatty acid metabolic process
positive regulation of cell-matrix adhesion
pattern recognition receptor signaling pathway
negative regulation of systemic arterial blood pressure
fatty acid metabolic process
triglyceride metabolic process
receptor-mediated endocytosis
phagocytosis, recognition
cell adhesion
signal transduction
cell surface receptor signaling pathway
nitric oxide mediated signal transduction
response to nutrient
response to mechanical stimulus
negative regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol storage
response to activity
fatty acid transport
long-chain fatty acid transport
plasma membrane long-chain fatty acid transport
negative regulation of angiogenesis
fatty acid oxidation
lipid storage
cGMP-mediated signaling
positive regulation of blood coagulation
cholesterol transport
response to estradiol
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
cellular response to insulin stimulus
plasma lipoprotein particle clearance
low-density lipoprotein particle clearance
response to drug
lipoprotein transport
negative regulation of transcription factor import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
apoptotic cell clearance
positive regulation of MAPK cascade
negative regulation of growth of symbiont in host
long-chain fatty acid import
digestive tract development
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-positive bacterium
low-density lipoprotein particle mediated signaling
positive regulation of phagocytosis, engulfment
response to growth hormone
positive regulation of macrophage cytokine production
cellular response to bacterial lipopeptide
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to hydroperoxide
regulation of removal of superoxide radicals
positive regulation of blood microparticle formation
positive regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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