Product References
Sequence-based drug design as a concept in computational drug design.
Nature communications
Chen L,Fan Z,Chang J,Yang R,Hou H,Guo H,Zhang Y,Yang T,Zhou C,Sui Q,Chen Z,Zheng C,Hao X,Zhang K,Cui R,Zhang Z,Ma H,Ding Y,Zhang N,Lu X,Luo X,Jiang H,Zhang S,Zheng M
12-5870-82 was used in Flow cytometry/Cell sorting to show that the sequence-to-drug concept adds a perspective on drug design.
Fri Jul 14 00:00:00 EDT 2023
Sequence-based drug design as a concept in computational drug design.
Nature communications
Chen L,Fan Z,Chang J,Yang R,Hou H,Guo H,Zhang Y,Yang T,Zhou C,Sui Q,Chen Z,Zheng C,Hao X,Zhang K,Cui R,Zhang Z,Ma H,Ding Y,Zhang N,Lu X,Luo X,Jiang H,Zhang S,Zheng M
12-5870-82 was used in Flow cytometry/Cell sorting to show that the sequence-to-drug concept adds a perspective on drug design.
Fri Jul 14 00:00:00 EDT 2023
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness.
Nature metabolism
Cheng H,Qiu Y,Xu Y,Chen L,Ma K,Tao M,Frankiw L,Yin H,Xie E,Pan X,Du J,Wang Z,Zhu W,Chen L,Zhang L,Li G
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2023
TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.
Biology
Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Thu Nov 03 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion.
iScience
Ma K,Sun L,Shen M,Zhang X,Xiao Z,Wang J,Liu X,Jiang K,Xiao-Feng Qin F,Guo F,Zhang B,Zhang L
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Fri May 20 00:00:00 EDT 2022
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Cell reports
Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.
Nature communications
Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Thu Aug 26 00:00:00 EDT 2021
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
12-5870 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
Therapeutic advances in medical oncology
Doo DW,Meza-Perez S,Londoño AI,Goldsberry WN,Katre AA,Boone JD,Moore DJ,Hudson CT,Betella I,McCaw TR,Gangrade A,Bao R,Luke JJ,Yang ES,Birrer MJ,Starenki D,Cooper SJ,Buchsbaum DJ,Norian LA,Randall TD,Arend RC
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2022
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy.
Nature communications
Baumann D,Hägele T,Mochayedi J,Drebant J,Vent C,Blobner S,Noll JH,Nickel I,Schumacher C,Boos SL,Daniel AS,Wendler S,Volkmar M,Strobel O,Offringa R
12-5870 was used in Flow cytometry/Cell sorting to show that targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) does not impair dendritic cell-mediated T cell priming and activation.
Fri May 01 00:00:00 EDT 2020
Lysosome Dynamic Properties during Neuronal Stem Cell Differentiation Studied by Spatiotemporal Fluctuation Spectroscopy and Organelle Tracking.
International journal of molecular sciences
Durso W,Martins M,Marchetti L,Cremisi F,Luin S,Cardarelli F
12-5870 was used in Flow cytometry/Cell sorting to investigate lysosome dynamics during neuronal stem cell (NSC) differentiation.
Mon May 11 00:00:00 EDT 2020
Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.
Communications biology
Benitez AA,Khalil-Agüero S,Nandakumar A,Gupta NT,Zhang W,Atwal GS,Murphy AJ,Sleeman MA,Haxhinasto S
12-5870 was used in Flow cytometry/Cell sorting to show that tumor rejection induced by immune checkpoint blockade is significantly enhanced in Aire-deficient mice, the epitome of central tolerance breakdown.
Wed Jul 08 00:00:00 EDT 2020
Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.
Cellular & molecular immunology
Du X,Wu Z,Xu Y,Liu Y,Liu W,Wang T,Li C,Zhang C,Yi F,Gao L,Liang X,Ma C
12-5870 was used in Flow cytometry/Cell sorting to analyze Tim-3 expression on different subpopulations of liver macrophages and further investigate the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice.
Fri Nov 01 00:00:00 EDT 2019
Mapping the Lineage Relationship between CXCR5+ and CXCR5- CD4+ T Cells in HIV-Infected Human Lymph Nodes.
Cell reports
Del Alcazar D,Wang Y,He C,Wendel BS,Del Río-Estrada PM,Lin J,Ablanedo-Terrazas Y,Malone MJ,Hernandez SM,Frank I,Naji A,Reyes-Terán G,Jiang N,Su LF
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Tue Sep 17 00:00:00 EDT 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
12-5870 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.
Thu Sep 05 00:00:00 EDT 2019
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.
Nature communications
Yasuda K,Kitagawa Y,Kawakami R,Isaka Y,Watanabe H,Kondoh G,Kohwi-Shigematsu T,Sakaguchi S,Hirota K
12-5870-82 was used in Flow Cytometry to indicate that Satb1 regulates the specific gene expression and function of effector Th17 cells in tissue inflammation.
Fri Feb 01 00:00:00 EST 2019
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
12-5870 was used in Flow cytometry/Cell sorting to set the foundation and show the importance of a combinatorial therapeutic strategy using pulsatile targeted therapy together with immunotherapy to optimally enhance tumor delay and promote long-term anti-tumor immunity.
Tue Apr 16 00:00:00 EDT 2019
Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway.
Molecular metabolism
Yang H,Xie T,Li D,Du X,Wang T,Li C,Song X,Xu L,Yi F,Liang X,Gao L,Yang X,Ma C
12-5870 was used in Flow cytometry/Cell sorting to study T cell immunoglobulin domain and mucin domain-3 as a regulator in renal inflammation.
Wed May 01 00:00:00 EDT 2019
Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.
Frontiers in microbiology
Hou N,Jiang N,Zou Y,Piao X,Liu S,Li S,Chen Q
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Nature communications
Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ
12-5870 was used in Flow cytometry/Cell sorting to show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8(+) T-cell response.
Thu Aug 24 00:00:00 EDT 2017
Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer.
Cancer research
Liu J,Blake SJ,Harjunpää H,Fairfax KA,Yong MC,Allen S,Kohrt HE,Takeda K,Smyth MJ,Teng MW
12-5870 was used in Flow cytometry/Cell sorting to develop a model that may be used to preclinically assess the therapeutic window of novel immunotherapy combinations in different tumor types.
Thu Sep 15 00:00:00 EDT 2016
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Oncoimmunology
Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Oncoimmunology
Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype.
Oncoimmunology
Shrestha S,Noh JM,Kim SY,Ham HY,Kim YJ,Yun YJ,Kim MJ,Kwon MS,Song DK,Hong CW
12-5870 was used in Flow cytometry/Cell sorting to investigate how modulation of Ang II pathway attenuates tumour growth via polarisation of neutrophils to an antitumoural phenotype.
Tue Jan 12 00:00:00 EST 2021
Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.
Journal of hepatology
Liu Y,Ji H,Zhang Y,Shen X,Gao F,He X,Li GA,Busuttil RW,Kuchroo VK,Kupiec-Weglinski JW
12-5870 was used in Flow cytometry/Cell sorting to investigate whether negative T cell-dependent TIM-3 co-stimulation rescues orthotopic liver transplants stressed by ischaemia-reperfusion from innate immunity-driven inflammation.
Sun Mar 01 00:00:00 EST 2015
Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection.
Infection and immunity
Hou N,Piao X,Liu S,Wu C,Chen Q
Published figure using CD366 (TIM3) monoclonal antibody (Product # 12-5870-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Nature communications
Koh HS,Chang CY,Jeon SB,Yoon HJ,Ahn YH,Kim HS,Kim IH,Jeon SH,Johnson RS,Park EJ
12-5870 was used in Flow cytometry/Cell sorting to investigate the role of TIM-3 in inflammation and damage following ischaemia.
Fri Mar 20 00:00:00 EDT 2015
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
12-5870 was used in Flow cytometry/Cell sorting to reveal a link between EMT and T-cell dysfunction and show that ZEB1 promotes metastasis through a cell non-autonomous mechanism.
Tue Oct 28 00:00:00 EDT 2014
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
12-5870 was used in Flow cytometry/Cell sorting to reveal a link between EMT and T-cell dysfunction and show that ZEB1 promotes metastasis through a cell non-autonomous mechanism.
Tue Oct 28 00:00:00 EDT 2014
Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection.
PloS one
Cyktor JC,Carruthers B,Beamer GL,Turner J
12-5870 was used in Flow cytometry/Cell sorting to study the presence of interleukin-10 secreting CD8 T cells during chronic Mycobacterium tuberculosis infection.
Tue Dec 03 00:00:00 EST 2013
Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.
The Journal of biological chemistry
Steelman AJ,Smith R,Welsh CJ,Li J
12-5870 was used in Flow cytometry/Cell sorting to investigate the role of galectin-9 in the pathogenesis of multiple sclerosis.
Fri Aug 16 00:00:00 EDT 2013
Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection.
Journal of immunology (Baltimore, Md. : 1950)
Lin E,Kemball CC,Hadley A,Wilson JJ,Hofstetter AR,Pack CD,Lukacher AE
12-5870 was used in Flow cytometry/Cell sorting to investigate the heterogeneity in the viral antigen-specific CD4+ T cell responses to chronic polyomavirus infection.
Sun Aug 01 00:00:00 EDT 2010
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.
Blood
Nakayama M,Akiba H,Takeda K,Kojima Y,Hashiguchi M,Azuma M,Yagita H,Okumura K
Thu Apr 16 00:00:00 EDT 2009
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.
Blood
Nakayama M,Akiba H,Takeda K,Kojima Y,Hashiguchi M,Azuma M,Yagita H,Okumura K
Thu Apr 16 00:00:00 EDT 2009
Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response.
Infection and immunity
Guerrero A,Fries BC
12-5870 was used in Flow cytometry/Cell sorting to compare survival rates and characterise the host responses of C. neoformans-resistant mice.
Mon Sep 01 00:00:00 EDT 2008
Role of interleukin-1beta in activating the CD11c(high) CD45RB- dendritic cell subset and priming Leishmania amazonensis-specific CD4+ T cells in vitro and in vivo.
Infection and immunity
Xin L,Li Y,Soong L
12-5870 was used in Flow cytometry/Cell sorting to investigate the mechanism by which the Leishmania amazonensis parasite modulates antigen-presenting cells and disrupts the immune system.
Mon Oct 01 00:00:00 EDT 2007
