Proteintech

CD42b Polyclonal Antibody

CD42b Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

CD42b Antibody (12860-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human spleen tissue slide using 12860-1-AP ( CD42b antibody at dilution of 1:200 (under 40x lens).

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Product Details

12860-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD42b Fusion Protein Ag3893 (19-350 aa encoded by BC027955)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ICEVSKVAS HLEVNCDKRN LTALPPDLPK DTTILHLSEN LLYTFSLATL MPYTRLTQLN LDRCELTKLQ VDGTLPVLGT LDLSHNQLQS LPLLGQTLPA LTVLDVSFNR LTSLPLGALR GLGELQELYL KGNELKTLPP GLLTPTPKLE KLSLANNNLT ELPAGLLNGL ENLDTLLLQE NSLYTIPKGF FGSHLLPFAF LHGNPWLCNC EILYFRRWLQ DNAENVYVWK QGVDVKAMTS NVASVQCDNS DKFPVYKYPG KGCPTLGDEG DTDLYDYYPE EDTEGDKVRA TRTVVKFPTK AHTTPWGLFY SWSTASLDSQ MPSSLHPTQE STK (19-350 aa encoded by BC027955)

Target Information

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Ishii D,Matsuno N,Gochi M,Iwata H,Shonaka T,Nishikawa Y,Obara H,Yokoo H,Furukawa H

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Bioinformatics

Protein Aliases: Antigen CD42b-alpha; CD42b; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ibalpha; GP-Ib alpha; GPIB; GPIb alpha; GPIX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; Platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha

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Gene Aliases: BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GP1BA; GPIBA; GPIbalpha; VWDP

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UniProt ID: (Human) P07359, (Mouse) O35930

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Entrez Gene ID: (Human) 2811, (Pig) 100515052, (Mouse) 14723

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Function(s)

protein kinase inhibitor activity protein binding thrombin receptor activity

Process(es)

cell morphogenesis negative regulation of protein kinase activity cell adhesion cell surface receptor signaling pathway blood coagulation blood coagulation, intrinsic pathway cytokine-mediated signaling pathway platelet activation regulation of blood coagulation fibrinolysis negative regulation of JAK-STAT cascade thrombin receptor signaling pathway hemostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD42b Polyclonal Antibody

CD42b Antibody (12860-1-AP) in IHC (P)

Product Details

12860-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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