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Product Details
12494-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD46 Fusion Protein Ag3131 (38-340 aa encoded by BC030594)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PPTFEAMEL IGKPKPYYEI GERVDYKCKK GYFYIPPLAT HTICDRNHTW LPVSDDACYR ETCPYIRDPL NGQAVPANGT YEFGYQMHFI CNEGYYLIGE EILYCELKGS VAIWSGKPPI CEKVLCTPPP KIKNGKHTFS EVEVFEYLDA VTYSCDPAPG PDPFSLIGES TIYCGDNSVW SRAAPECKVV KCRFPVVENG KQISGFGKKF YYKATVMFEC DKGFYLDGSD TIVCDSNSTW DPPVPKCLKV STSSTTKSPA SSASGPRPTY KPPVSNYPGY PKPEEGILDS LDVWVIAVIV IAIV (38-340 aa encoded by BC030594)
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; TLX; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
Gene Aliases: AHUS2; CD46; MCP; MIC10; TLX; TRA2.10
UniProt ID: (Human) P15529, (Mouse) O88174
Entrez Gene ID: (Human) 4179, (Mouse) 17221
T cell mediated immunity
proteolysis
single fertilization
regulation of Notch signaling pathway
positive regulation of gene expression
negative regulation of gene expression
interleukin-10 production
positive regulation of interleukin-10 production
sequestering of extracellular ligand from receptor
positive regulation of T cell proliferation
negative regulation of catalytic activity
positive regulation of memory T cell differentiation
positive regulation of regulatory T cell differentiation
negative regulation of complement activation
positive regulation of transforming growth factor beta production
adaptive immune response
complement activation, classical pathway
regulation of complement activation
innate immune response
viral entry into host cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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