Product References
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment.
Cellular & molecular biology letters
Meng Y,Pospiech M,Ali A,Chandwani R,Vergel M,Onyemaechi S,Yaghmour G,Lu R,Alachkar H
11-0481-82 was used in Flow cytometry/Cell sorting to investigate whether targeting CD36 has any detrimental impact on normal hematopoietic cells.
Wed May 24 00:00:00 EDT 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
11-0481-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
Nociceptive nerves regulate haematopoietic stem cell mobilization.
Nature
Gao X,Zhang D,Xu C,Li H,Caron KM,Frenette PS
Published figure using CD48 monoclonal antibody (Product # 11-0481-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Conditionally pathogenic genetic variants of a hematopoietic disease-suppressing enhancer.
Science advances
Soukup AA,Matson DR,Liu P,Johnson KD,Bresnick EH
Published figure using CD48 monoclonal antibody (Product # 11-0481-82) in Flow Cytometry
Fri Dec 10 00:00:00 EST 2021
MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells.
Nature communications
Wei Q,Pinho S,Dong S,Pierce H,Li H,Nakahara F,Xu J,Xu C,Boulais PE,Zhang D,Maryanovich M,Cuervo AM,Frenette PS
Published figure using CD48 monoclonal antibody (Product # 11-0481-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress.
Cell death & disease
Tung LT,Wang H,Belle JI,Petrov JC,Langlais D,Nijnik A
11-0481-82 was used in Flow Cytometry to analyze the in vivo transcriptional response of hematopoietic stem and progenitor cells to genotoxic stress in a mouse whole-body irradiation model and characterize the p53-dependent and p53-independent branches of this transcriptional response.
Fri Oct 08 00:00:00 EDT 2021
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.
Nature immunology
Muto T,Walker CS,Choi K,Hueneman K,Smith MA,Gul Z,Garcia-Manero G,Ma A,Zheng Y,Starczynowski DT
11-0481 was used in Flow cytometry/Cell sorting to show that chronic inflammation is a determinant for the competitive advantage of myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells (HSPCs) and for disease progression.
Fri May 01 00:00:00 EDT 2020
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency.
Cell stem cell
Liang R,Arif T,Kalmykova S,Kasianov A,Lin M,Menon V,Qiu J,Bernitz JM,Moore K,Lin F,Benson DL,Tzavaras N,Mahajan M,Papatsenko D,Ghaffari S
11-0481-82 was used in Flow Cytometry to investigate the overall metabolic properties of hematopoietic stem cells.
Thu Mar 05 00:00:00 EST 2020
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Developmental cell
Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS
11-0481-82 was used in Immunohistochemistry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.
Mon Jun 08 00:00:00 EDT 2020
HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.
Cell reports
Chen C,Sun MA,Warzecha C,Bachu M,Dey A,Wu T,Adams PD,Macfarlan T,Love P,Ozato K
11-0481 was used in Flow cytometry/Cell sorting to show that HIRA provides a chromatin environment essential for HSCs, thereby steering their development and survival.
Tue Feb 18 00:00:00 EST 2020
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Cell stem cell
Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK
11-0481 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.
Thu Apr 04 00:00:00 EDT 2019
Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.
The Journal of clinical investigation
Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH
Published figure using CD48 monoclonal antibody (Product # 11-0481-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2019
Classification of mouse B cell types using surfaceome proteotype maps.
Nature communications
van Oostrum M,Müller M,Klein F,Bruderer R,Zhang H,Pedrioli PGA,Reiter L,Tsapogas P,Rolink A,Wollscheid B
11-0481 was used in Flow cytometry/Cell sorting to develop population-specific surfaceome proteotype maps to classify developing B cell types in mice.
Mon Dec 16 00:00:00 EST 2019
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Cell stem cell
Hsu JI,Dayaram T,Tovy A,De Braekeleer E,Jeong M,Wang F,Zhang J,Heffernan TP,Gera S,Kovacs JJ,Marszalek JR,Bristow C,Yan Y,Garcia-Manero G,Kantarjian H,Vassiliou G,Futreal PA,Donehower LA,Takahashi K,Goodell MA
11-0481 was used in Flow cytometry/Cell sorting to establish the clinical relevance of PPM1D mutations in clonal haematopoiesis and the importance of studying mutation-treatment interactions.
Thu Nov 01 00:00:00 EDT 2018
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using CD48 monoclonal antibody (Product # 11-0481-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
Developmental cell
Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH
11-0481 was used in Flow cytometry/Cell sorting to propose that Samd14-Enh and an ensemble of anemia-responsive enhancers are essential for erythrocyte regeneration in stress erythropoiesis.
Mon Aug 07 00:00:00 EDT 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Tue Dec 12 00:00:00 EST 2017
Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.
Cell reports
Mehta C,Johnson KD,Gao X,Ong IM,Katsumura KR,McIver SC,Ranheim EA,Bresnick EH
Published figure using CD48 monoclonal antibody (Product # 11-0481-82) in Flow Cytometry
Tue Sep 19 00:00:00 EDT 2017
MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.
The Journal of clinical investigation
Zhu N,Chen M,Eng R,DeJong J,Sinha AU,Rahnamay NF,Koche R,Al-Shahrour F,Minehart JC,Chen CW,Deshpande AJ,Xu H,Chu SH,Ebert BL,Roeder RG,Armstrong SA
11-0481 was used in Flow cytometry/Cell sorting to show that loss of JMJD1C substantially decreased LSC frequency and caused differentiation of MLL-AF9- and homeobox A9-driven leukemias.
Tue Mar 01 00:00:00 EST 2016
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Cell death and differentiation
Belle JI,Petrov JC,Langlais D,Robert F,Cencic R,Shen S,Pelletier J,Gros P,Nijnik A
11-0481 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the transcriptional activation of p53 stress responses in Mysm1-deficient haematopoietic stem and progenitor cells.
Sun May 01 00:00:00 EDT 2016
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
eLife
Yue R,Shen B,Morrison SJ
11-0481 was used in Flow cytometry/Cell sorting to study how Clec11a/Osteolectin maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.
Tue Dec 13 00:00:00 EST 2016
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
11-0481 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 EST 2016
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
11-0481 was used in Flow cytometry/Cell sorting to illustrate a paradigm in which cis-elements in a locus differentially control stem and progenitor cell transitions.
Tue Sep 01 00:00:00 EDT 2015
High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.
Stem cell research
Rao TN,Marks-Bluth J,Sullivan J,Gupta MK,Chandrakanthan V,Fitch SR,Ottersbach K,Jang YC,Piao X,Kulkarni RN,Serwold T,Pimanda JE,Wagers AJ
11-0481 was used in Flow cytometry/Cell sorting to indicate that high-level expression of GPR56 by primitive HSPCs is largely dispensable for steady-state and regenerative hematopoiesis.
Fri May 01 00:00:00 EDT 2015
Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.
Nature communications
Lee CL,Castle KD,Moding EJ,Blum JM,Williams N,Luo L,Ma Y,Borst LB,Kim Y,Kirsch DG
11-0481 was used in Flow cytometry/Cell sorting to show that total-body irradiation promotes the expansion of a rare population of thymocytes that express oncogenic Kras(G12D).
Thu Sep 24 00:00:00 EDT 2015
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.
The Journal of clinical investigation
Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH
11-0481 was used in Flow cytometry/Cell sorting to identify a novel mutation in a GATA2 cis-element which causes deficits in haematopoietic stem/progenitor activity.
Mon Oct 01 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
11-0481 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression.
Blood
Tzeng YS,Li H,Kang YL,Chen WC,Cheng WC,Lai DM
11-0481 was used in Immunofluorescence to elucidate the function of the chemokine, Cxcl12, in adult hematopoietic stem/progenitor cell (HSPC) regulation.
Thu Jan 13 00:00:00 EST 2011
Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress.
Antioxidants & redox signaling
Lorenzo LP,Chen H,Shatynski KE,Clark S,Yuan R,Harrison DE,Yarowsky PJ,Williams MS
11-0481 was used in Flow cytometry/Cell sorting to identify a link between oxidative stress and diminished IL-7Rα expression and function associated with defective haematologic development in a DS mouse model.
Sat Oct 15 00:00:00 EDT 2011
Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells.
Blood
Tolar J,Ishida-Yamamoto A,Riddle M,McElmurry RT,Osborn M,Xia L,Lund T,Slattery C,Uitto J,Christiano AM,Wagner JE,Blazar BR
11-0481 was used in Flow cytometry/Cell sorting to investigate whether bone marrow cell infusion can be used to treat disease in a murine model of recessive dystrophic epidermolysis bullosa.
Thu Jan 29 00:00:00 EST 2009