Product References
Cissus quadrangularis (Hadjod) Inhibits RANKL-Induced Osteoclastogenesis and Augments Bone Health in an Estrogen-Deficient Preclinical Model of Osteoporosis Via Modulating the Host Osteoimmune System.
Cells
Azam Z,Sapra L,Baghel K,Sinha N,Gupta RK,Soni V,Saini C,Mishra PK,Srivastava RK
Published figure using CD5 monoclonal antibody (Product # 12-0051-82) in Flow Cytometry
Wed Jan 04 00:00:00 EST 2023
IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.
Nature communications
Xu L,Wei C,Chen Y,Wu Y,Shou X,Chen W,Lu D,Sun H,Li W,Yu B,Wang X,Zhang X,Yu Y,Lei Z,Tang R,Zhu J,Li Y,Lu L,Zhou H,Zhou S,Su C,Chen X
Published figure using CD5 monoclonal antibody (Product # 12-0051-82) in Flow Cytometry
Sat Nov 12 00:00:00 EST 2022
Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice.
Cell reports
Worth AN,Palmer VL,Schabla NM,Perry GA,Fraser-Philbin AN,Swanson PC
12-0051-82 was used in flow cytometry to find that B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by VH12/Vκ4/5H.
Tue Jun 14 00:00:00 EDT 2022
The mammalian SKIV2L RNA exosome is essential for early B cell development.
Science immunology
Yang K,Han J,Gill JG,Park JY,Sathe MN,Gattineni J,Wright T,Wysocki C,de la Morena MT,Yan N
12-0051-82 was used in Flow cytometry/Cell sorting to demonstrate a crucial role for SKIV2L RNA exosome in early B cell development in both human and mice by ensuring proper V(D)J recombination and Igh expression.
Fri Jun 03 00:00:00 EDT 2022
A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.
Nature communications
Wu J,Yang K,Cai S,Zhang X,Hu L,Lin F,Wu SQ,Xiao C,Liu WH,Han J
12-0051-82 was used in Flow cytometry/Cell sorting to show that plasma cell differentiation and antibody responses are severely impaired in mice with B-cell-specific deletion of p38α, while B-cell development and the germinal centre B-cell response are spared.
Mon Nov 28 00:00:00 EST 2022
Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis.
The FEBS journal
Hutter K,Rülicke T,Drach M,Andersen L,Villunger A,Herzog S
12-0051 was used in Flow cytometry/Cell sorting to postulate that the miR-497/195 cluster is redundant to its paralog clusters or that its functional relevance is restricted to certain physiological and pathological conditions.
Mon Mar 01 00:00:00 EST 2021
T cell self-reactivity during thymic development dictates the timing of positive selection.
eLife
Lutes LK,Steier Z,McIntyre LL,Pandey S,Kaminski J,Hoover AR,Ariotti S,Streets A,Yosef N,Robey EA
12-0051-82 was used in Flow Cytometry to imply that thymocytes with low self-reactivity downregulate TCR sensitivity more slowly during positive selection, and associate membrane ion channel expression with thymocyte self-reactivity and progress through positive selection.
Thu Apr 22 00:00:00 EDT 2021
The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae.
Frontiers in immunology
Ercoli G,Ramos-Sevillano E,Nakajima R,de Assis RR,Jasinskas A,Goldblatt D,Felgner P,Weckbecker G,Brown J
Published figure using CD5 monoclonal antibody (Product # 12-0051-82) in Flow Cytometry
Tue Jun 22 00:00:00 EDT 2021
Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production.
Journal of visualized experiments : JoVE
Upadhye A,Marshall M,Garmey JC,Bender TP,McNamara C
12-0051 was used in Flow cytometry/Cell sorting to describe a method to target B-1a cell migration to the bone marrow by retroviral-mediated overexpression of the C-X-C motif chemokine receptor 4 (CXCR4).
Sun May 31 00:00:00 EDT 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
12-0051-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
12-0051 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.
Frontiers in immunology
Baur J,Otto C,Steger U,Klein-Hessling S,Muhammad K,Pusch T,Murti K,Wismer R,Germer CT,Klein I,Müller N,Serfling E,Avots A
12-0051 was used in Flow cytometry/Cell sorting to show that the activity of nuclear factors of activated T cells-c1 supports the acute rejection of heterotopic heart allografts.
Wed Nov 20 00:00:00 EST 2019
Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.
Journal of virology
Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF
Published figure using CD5 monoclonal antibody (Product # 12-0051-82) in Flow Cytometry
Thu Mar 15 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Thu Sep 06 00:00:00 EDT 2018
STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.
Cell reports
Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S
Tue Sep 11 00:00:00 EDT 2018
CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.
Molecular cell
Ren G,Jin W,Cui K,Rodrigez J,Hu G,Zhang Z,Larson DR,Zhao K
Published figure using CD5 monoclonal antibody (Product # 12-0051-82) in Flow Cytometry
Thu Sep 21 00:00:00 EDT 2017
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
12-0051 was used in Flow cytometry/Cell sorting to demonstrate two distinct signalling pathways for TLR4, one via the BCR and the other through MYD88.
Mon May 01 00:00:00 EDT 2017
ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Dang J,Bian X,Ma X,Li J,Long F,Shan S,Yuan Q,Xin Q,Li Y,Gao F,Gong Y,Liu Q
12-0051 was used in Flow cytometry/Cell sorting to study the upregulation of orosomucoid-like 3 in both patients with systemic lupus erythematosus and lupus mice compared with controls.
Fri Sep 01 00:00:00 EDT 2017
Naïve helper T cells with high CD5 expression have increased calcium signaling.
PloS one
Freitas CMT,Hamblin GJ,Raymond CM,Weber KS
Tue Sep 26 00:00:00 EDT 2017
Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms.
Blood
Lykken JM,Horikawa M,Minard-Colin V,Kamata M,Miyagaki T,Poe JC,Tedder TF
12-0051 was used in Flow cytometry/Cell sorting to elucidate the mechanisms through which non-Hodgkin lymphomas initially resist or gain resistance to immunotherapy.
Thu Apr 14 00:00:00 EDT 2016
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology
Srikakulapu P,Hu D,Yin C,Mohanta SK,Bontha SV,Peng L,Beer M,Weber C,McNamara CA,Grassia G,Maffia P,Manz RA,Habenicht AJ
12-0051 was used in Flow cytometry/Cell sorting to study how artery tertiary lymphoid organs can orchestrate B-cell responses in the diseased aorta.
Wed Jun 01 00:00:00 EDT 2016
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Nature communications
Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E
Published figure using CD5 monoclonal antibody (Product # 12-0051-82) in Flow Cytometry
Wed May 25 00:00:00 EDT 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
12-0051 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 EDT 2017
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
Nature medicine
Ortega-Molina A,Boss IW,Canela A,Pan H,Jiang Y,Zhao C,Jiang M,Hu D,Agirre X,Niesvizky I,Lee JE,Chen HT,Ennishi D,Scott DW,Mottok A,Hother C,Liu S,Cao XJ,Tam W,Shaknovich R,Garcia BA,Gascoyne RD,Ge K,Shilatifard A,Elemento O,Nussenzweig A,Melnick AM,Wendel HG
12-0051 was used in Flow cytometry/Cell sorting to show that KMT2D mutations may promote malignant outgrowth by perturbing the expression of genes that control B cell-activating pathways.
Thu Oct 01 00:00:00 EDT 2015
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
12-0051 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.
Journal of immunology (Baltimore, Md. : 1950)
Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P
Published figure using CD5 monoclonal antibody (Product # 12-0051-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Reynolds AE,Kuraoka M,Kelsoe G
12-0051 was used in Flow cytometry/Cell sorting to investigate the origin of natural IgM, showing that it is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Thu Jan 01 00:00:00 EST 2015
Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.
BioMed research international
Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC
12-0051-82 was used in Flow Cytometry to suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.
Mon Aug 01 00:00:00 EDT 2016
Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
Nature immunology
Au-Yeung BB,Melichar HJ,Ross JO,Cheng DA,Zikherman J,Shokat KM,Robey EA,Weiss A
12-0051 was used in Flow cytometry/Cell sorting to show that CD4(+)CD8(+) thymocytes integrate multiple, transient, Zap70-dependent signals over more than 36 h to reach a cumulative threshold for positive selection.
Tue Jul 01 00:00:00 EDT 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
12-0051 was used in Flow cytometry/Cell sorting to assess the effect of eosinophils on B cell survival, proliferation, and Ig secretion.
Tue Apr 15 00:00:00 EDT 2014
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene
Baumgartner F,Woess C,Pedit V,Tzankov A,Labi V,Villunger A
12-0051 was used in Flow cytometry/Cell sorting to show that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation in mice.
Thu Jan 31 00:00:00 EST 2013
CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.
Journal of immunology (Baltimore, Md. : 1950)
Sestero CM,McGuire DJ,De Sarno P,Brantley EC,Soldevila G,Axtell RC,Raman C
12-0051 was used in Flow cytometry/Cell sorting to determine the physiological significance of CD5-dependent casein kinase 2 activation in T cells.
Sat Sep 15 00:00:00 EDT 2012
Dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunity.
The American journal of pathology
Wang JY,Lee J,Yan M,Rho JH,Roehrl MH
12-0051 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the positive selection and expansion of CD5(+) B cells, showing that dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate.
Sun May 01 00:00:00 EDT 2011
A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation.
Autoimmunity
Sweet RA,Christensen SR,Harris ML,Shupe J,Sutherland JL,Shlomchik MJ
12-0051 was used in Flow cytometry/Cell sorting to show that switched auto-Ab-forming cells develop robustly outside germinal centers, further confirming the extrafollicular expression of AID.
Wed Dec 01 00:00:00 EST 2010
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
Journal of immunological methods
Holl TM,Haynes BF,Kelsoe G
12-0051 was used in Flow cytometry/Cell sorting to describe a stromal cell independent culture system that efficiently supports pro-B cell to IgM+ B cell development with near normal levels of IgH and Igkappa diversity.
Wed Mar 31 00:00:00 EDT 2010
A possible contribution of retinoids to regulation of fetal B lymphopoiesis.
European journal of immunology
Chen X,Welner RS,Kincade PW
12-0051 was used in Flow cytometry/Cell sorting to determine that retinoids may partially account for rapid differentiation in foetal life, but not for all unique features of foetal progenitors.
Tue Sep 01 00:00:00 EDT 2009
CD11c expression identifies a population of extrafollicular antigen-specific splenic plasmablasts responsible for CD4 T-independent antibody responses during intracellular bacterial infection.
Journal of immunology (Baltimore, Md. : 1950)
Racine R,Chatterjee M,Winslow GM
12-0051 was used in Flow cytometry/Cell sorting to study how during this intracellular bacterial infection, CD11c expression identifies a population of Ag-specific spleen plasmablasts responsible for T-independent Ab production.
Tue Jul 15 00:00:00 EDT 2008
EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas.
PLoS pathogens
Shair KH,Bendt KM,Edwards RH,Bedford EC,Nielsen JN,Raab-Traub N
12-0051 was used in Flow cytometry/Cell sorting to suggest that Akt, NFkappaB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.
Thu Nov 01 00:00:00 EDT 2007
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
12-0051 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 EST 2006
B1b lymphocytes confer T cell-independent long-lasting immunity.
Immunity
Alugupalli KR,Leong JM,Woodland RT,Muramatsu M,Honjo T,Gerstein RM
12-0051 was used in Flow cytometry/Cell sorting to demonstrate that B1b lymphocytes provide long-lasting T cell-independent IgM memory and a successful resolution of Borrelia hermsiibacteremia in mice.
Wed Sep 01 00:00:00 EDT 2004
