Invitrogen

CD56 Monoclonal Antibody (MEM-188)

Product Details

MHCD5600

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-Dependent

View 7 publications 7 publications

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rhesus monkey

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

MEM-188

Immunogen

Human CD56

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10372521

Target Information

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

Analyte Specific Reagent

Product References

Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Kim JM,Kwon CHD,Joh JW,Sinn DH,Choi GS,Park JB,Kang ES,Lee SK

MHCD5600 was used in flow cytometry to characterize the periferal blood lymphocytes phenotype in tacrolimus-treated liver transplanted patients.

Mon Mar 19 00:00:00 EDT 2018

Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

Journal of immunology (Baltimore, Md. : 1950)

DeGottardi MQ,Okoye AA,Vaidya M,Talla A,Konfe AL,Reyes MD,Clock JA,Duell DM,Legasse AW,Sabnis A,Park BS,Axthelm MK,Estes JD,Reiman KA,Sekaly RP,Picker LJ

MHCD5600 was used in flow cytometry to report the effect of IL-15 inhibition on T and natural killer cell dynamics in rhesus macaques

Mon Aug 15 00:00:00 EDT 2016

LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells.

Nature communications

Lu XJ,Chen Q,Rong YJ,Yang GJ,Li CH,Xu NY,Yu CH,Wang HY,Zhang S,Shi YH,Chen J

MHCD5600 was used in flow cytometry to find that leukocyte cell-derived chemotaxin 2 promotes expansion and mobilization of hematopoietic stem cells

Tue Sep 06 00:00:00 EDT 2016

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.

Nature chemical biology

Okoye-Okafor UC,Bartholdy B,Cartier J,Gao EN,Pietrak B,Rendina AR,Rominger C,Quinn C,Smallwood A,Wiggall KJ,Reif AJ,Schmidt SJ,Qi H,Zhao H,Joberty G,Faelth-Savitski M,Bantscheff M,Drewes G,Duraiswami C,Brady P,Groy A,Narayanagari SR,Antony-Debre I,Mitchell K,Wang HR,Kao YR,Christopeit M,Carvajal L,Barreyro L,Paietta E,Makishima H,Will B,Concha N,Adams ND,Schwartz B,McCabe MT,Maciejewski J,Verma A,Steidl U

MHCD5600 was used in flow cytometry to assess the effects of allosteric inhibitors on different mutant forms of isocitrate dehydrogenase 1 in leukemia

Sun Nov 01 00:00:00 EDT 2015

Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1.

PloS one

Grieco AJ,Billett HH,Green NS,Driscoll MC,Bouhassira EE

MHCD5600 was used in flow cytometry to elucidate regulation of γ-globin expression in F-cells.

Mon Feb 29 00:00:00 EST 2016

Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART.

Retrovirology

DaFonseca S,Niessl J,Pouvreau S,Wacleche VS,Gosselin A,Cleret-Buhot A,Bernard N,Tremblay C,Jenabian MA,Routy JP,Ancuta P

MHCD5600 was used in flow cytometry to elucidate Th17 cell polarization, depletion, and restoration in response to HIV infection and antiretroviral therapy

Thu Apr 30 00:00:00 EDT 2015

The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.

Journal of cellular and molecular medicine

Elsner L,Flügge PF,Lozano J,Muppala V,Eiz-Vesper B,Demiroglu SY,Malzahn D,Herrmann T,Brunner E,Bickeböller H,Multhoff G,Walter L,Dressel R

MHCD5600 was used in flow cytometry to report that HSP70 activates human NK cells to kill target cells expressing MICA in a natural killer group 2 member D-dependent manner

Thu Apr 01 00:00:00 EDT 2010

A new protocol for multiple inhalation of IFN-gamma successfully treats MDR-TB: a case study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Grahmann PR,Braun RK

MHCD5600 was used in flow cytometry to demonstrate that aerosolized interferon-gamma results in the transient conversion of sputum smears in multidrug-resistant pulmonary tuberculosis

Sun Jun 01 00:00:00 EDT 2008

Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains.

Journal of immunology (Baltimore, Md. : 1950)

Steinberger P,Majdic O,Derdak SV,Pfistershammer K,Kirchberger S,Klauser C,Zlabinger G,Pickl WF,Stöckl J,Knapp W

MHCD5600 was used in flow cytometry to characterize B7-H3.

Sun Feb 15 00:00:00 EST 2004

LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

The Journal of experimental medicine

Brdicková N,Brdicka T,Angelisová P,Horváth O,Spicka J,Hilgert I,Paces J,Simeoni L,Kliche S,Merten C,Schraven B,Horejsí V

MHCD5600 was used in flow cytometry to describe a new raft-associated adaptor protein, Lck-interacting molecule, expressed predominantly in T lymphocytes.

Mon Nov 17 00:00:00 EST 2003

Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.

Blood

Kim CH,Johnston B,Butcher EC

MHCD5600 was used in flow cytometry to report differential expression of chemokine receptors among NKT cell subsets.

Mon Jul 01 00:00:00 EDT 2002

Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.

The Journal of experimental medicine

Lanier LL,Testi R,Bindl J,Phillips JH

MHCD5600 was used in immunoprecipitation to propose that the Leu-19 antigen on leukocytes contributes to cell adhesion and is analogous to N-CAM on neural cells.

Thu Jun 01 00:00:00 EDT 1989

Bioinformatics

Protein Aliases: antigen recognized by monoclonal antibody 5.1H11; CD-56; CD56; E NCAM; N CAM1; N-CAM-1; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM

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Gene Aliases: CD56; MSK39; NCAM; NCAM1

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UniProt ID: (Human) P13591

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Entrez Gene ID: (Human) 4684

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Function(s)

virus receptor activity Ras guanyl-nucleotide exchange factor activity

Process(es)

MAPK cascade cell adhesion axon guidance positive regulation of GTPase activity viral entry into host cell regulation of synaptic plasticity interferon-gamma-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD56 Monoclonal Antibody (MEM-188)

Product Details

MHCD5600

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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