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NeoBiotechnologies
CD6 Recombinant Rabbit Monoclonal Antibody (C6, 2884R)
Product Details
923-RBM5-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
C6, 2884R
Immunogen
Human recombinant full-length CD6 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD6; CD6 antigen; FLJ44171; T-cell differentiation antigen CD6; T12; TP120
Gene Aliases: CD6; TP120
UniProt ID: (Human) P30203
Entrez Gene ID: (Human) 923
immunological synapse formation
adaptive immune response
acute inflammatory response to antigenic stimulus
receptor-mediated endocytosis
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
positive regulation of T cell proliferation
innate immune response
positive regulation of cytokine production involved in inflammatory response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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