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Invitrogen
CD71 (Transferrin Receptor) Recombinant Rabbit Monoclonal Antibody (JF0956)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 8
CD71 (Transferrin Receptor) Antibody (MA5-32500) in IHC (P)
Immunohistochemistry analysis of CD71 (Transferrin Receptor) with paraffin-embedded human lung carcinoma. The tissues were blocked in 5% BSA (30 min, room temp), washed with ddH2O and PBS, incubated with recombinant monoclonal CD71 (Transferrin Receptor) (Product # MA5-32500) at a dilution of 1:50 (30 min, room temperature). Detection was performed with HRP, DAB was used as the chromogen, counterstained wit... View More
Product Details
MA5-32500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JF0956
Immunogen
Synthetic peptide within Human CD71 aa 22-60
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809777
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen CD71; CD71; mammary tumor virus receptor 1; p90; T9; tfR; tfR1; TR; Transferrin receptor protein 1
Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; IMD46; Mtvr-1; Mtvr1; p90; T9; TFR; TFR1; TFRC; TR; TRFR
UniProt ID: (Human) P02786, (Rat) Q99376, (Mouse) Q62351
Entrez Gene ID: (Human) 7037, (Rat) 64678, (Mouse) 22042
virus receptor activity
glycoprotein binding
double-stranded RNA binding
transferrin receptor activity
protein binding
Hsp70 protein binding
transferrin transmembrane transporter activity
identical protein binding
protein homodimerization activity
poly(A) RNA binding
chaperone binding
iron ion transmembrane transporter activity
metalloprotease
regulation of cell growth
response to hypoxia
cellular iron ion homeostasis
acute-phase response
aging
response to nutrient
response to iron ion
response to manganese ion
osteoclast differentiation
positive regulation of B cell proliferation
receptor internalization
response to retinoic acid
transferrin transport
cellular response to drug
positive regulation of T cell proliferation
regulation of cell proliferation
positive regulation of bone resorption
positive regulation of isotype switching
response to copper ion
viral entry into host cell
iron ion import
receptor-mediated endocytosis
response to organic substance
response to inorganic substance
endocytosis
iron ion transmembrane transport
protein transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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