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CD8 beta Antibody (MA1-10306) in Flow
Separation of rat CD8b positive splenocytes (red-filled) from CD8b negative splenocytes (black-dashed) in flow cytometry analysis (surface staining) of rat splenocyte suspension stained using anti-rat CD8b (341) purified Monoclonal antibody (Product # MA1-10306) (concentration in sample 1 µg/mL) GAM PE.
Product Details
MA1-10306
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
341
Immunogen
CD8 positive Wistar rat splenic T cell hybridomas
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153985
Product Specific Information
This antibody recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
Target Information
The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD8; CD8 antigen 37 kDa chain; CD8 antigen beta-chain; CD8 antigen, beta chain; CD8 antigen, beta-chain; CD8alpha; CD8b; CD8beta; Leu-2; MAL; OX-8 membrane antigen; T-cell surface glycoprotein CD8 beta chain
Gene Aliases: Cd8b; Cd8b1
UniProt ID: (Rat) P05541
Entrez Gene ID: (Rat) 24931
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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