Invitrogen

CD80 (B7-1) Monoclonal Antibody (16-10A1), eFluor™ 450, eBioscience™

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Antibody Testing Data (1)
Published Figures (62)

CD80 (B7-1) Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 63

CD80 (B7-1) Antibody (48-0801-82) in Flow

Staining of unstimulated (left) and 3-day LPS-stimulated BALB/c splenocytes (right) with 0.125 µg of Armenian Hamster IgG Isotype Control eFluor® 450 (Product # 48-4888-82) (blue histogram) or 0.125 µg of Anti-Mouse CD80 (B7-1) eFluor® 450 (purple histogram). Total viable cells, as determined by Fixable Viability Dye eFluor® 506, were used for analysis.

CD80 (B7-1) Antibody in Immunocytochemistry (ICC/IF)

CD80 (B7-1) Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Product Details

48-0801-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.25 µg/test

View 53 publications 53 publications

Product Specifications

Species Reactivity

Dog, Mouse, Pig

Published species

Mouse

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), eFluor™ 450, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

16-10A1

Conjugate

eFluor™ 450 eFluor™ 450 eFluor™ 450

Excitation/Emission Max

405/445 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2574029

Product Specific Information

Description: The 16-10A1 monoclonal antibody reacts with mouse CD80 (B7-1), a 55 kDa member of the Ig superfamily. CD80 is expressed by macrophages, dendritic cells and activated B cells. In addition, activated T cells express this antigen. CD80 has high affinity for binding to two T cell surface antigens, CD28 and CD152 (CTLA-4). The interaction of CD28 and CD152 with CD80 is crucial in T-B cell communication leading to activation of T and B cells, respectively.

Applications Reported: This 16-10A1 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This 16-10A1 antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.

Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

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In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses.

Nature communications

Guo Y,Wang SZ,Zhang X,Jia HR,Zhu YX,Zhang X,Gao G,Jiang YW,Li C,Chen X,Wu SY,Liu Y,Wu FG

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TcpC Inhibits M1 but Promotes M2 Macrophage Polarization via Regulation of the MAPK/NF-κB and Akt/STAT6 Pathways in Urinary Tract Infection.

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Sat Jan 29 00:00:00 EST 2022

Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy.

Theranostics

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A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis.

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Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.

International journal of molecular medicine

Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J

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Myeloid and plasmacytoid dendritic cell combined vaccines loaded with heat-treated tumor cell lysates enhance antitumor activity in murine lung cancer.

Oncology letters

Chen H,Tan J,Li X,Li H,Wu W,Wu Y,Zhang J,Gu L

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Receptor-selective interleukin-4 mutein attenuates laser-induced choroidal neovascularization through the regulation of macrophage polarization in mice.

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Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.

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Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

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Mon Nov 15 00:00:00 EST 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

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Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

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Thu Dec 09 00:00:00 EST 2021

Azithromycin alleviates systemic lupus erythematosus via the promotion of M2 polarisation in lupus mice.

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Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor.

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Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages.

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Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

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T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells.

Nature communications

Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD

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FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.

Frontiers in immunology

Pan YG,Yu YL,Lin CC,Lanier LL,Chu CL

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Wed Nov 20 00:00:00 EST 2019

Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.

Molecular medicine reports

Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N

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Wed Nov 01 00:00:00 EDT 2017

Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization.

Molecular medicine reports

Zhou Y,Yoshida S,Kubo Y,Yoshimura T,Kobayashi Y,Nakama T,Yamaguchi M,Ishikawa K,Oshima Y,Ishibashi T

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Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.

Experimental and therapeutic medicine

Wang J,Gao ZP,Qin S,Liu CB,Zou LL

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Sun Oct 01 00:00:00 EDT 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

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Sat Apr 01 00:00:00 EDT 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Mon Feb 06 00:00:00 EST 2017

Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.

Scientific reports

Wang H,Mo L,Xiao X,An S,Liu X,Ba J,Wu W,Ran P,Yang P,Liu Z

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

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Oncoimmunology

Shen Y,Guo D,Weng L,Wang S,Ma Z,Yang Y,Wang P,Wang J,Cai Z

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Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells.

Scientific reports

Wang H,Lin J,Zeng L,Ouyang C,Ran P,Yang P,Liu Z

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Thu Aug 17 00:00:00 EDT 2017

Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.

Stem cells translational medicine

Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.

Human vaccines & immunotherapeutics

Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Tue Aug 02 00:00:00 EDT 2016

CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice.

Experimental and therapeutic medicine

Li JG,DU YM,Yan ZD,Yan J,Zhuansun YX,Chen R,Zhang W,Feng SL,Ran PX

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

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Mon May 16 00:00:00 EDT 2016

ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration.

Cell reports

Zandi S,Nakao S,Chun KH,Fiorina P,Sun D,Arita R,Zhao M,Kim E,Schueller O,Campbell S,Taher M,Melhorn MI,Schering A,Gatti F,Tezza S,Xie F,Vergani A,Yoshida S,Ishikawa K,Yamaguchi M,Sasaki F,Schmidt-Ullrich R,Hata Y,Enaida H,Yuzawa M,Yokomizo T,Kim YB,Sweetnam P,Ishibashi T,Hafezi-Moghadam A

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Tue Feb 24 00:00:00 EST 2015

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.

Cellular immunology

Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

Lung dendritic cells undergo maturation and polarization towards a T helper type 2-stimulating phenotype in a mouse model of asthma: Role of nerve growth factor.

Experimental and therapeutic medicine

Qin Q,Wang Z,Pan P,Cao Z,Xia Q,Tan H,Hu C

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Sat Nov 01 00:00:00 EDT 2014

Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite.

PloS one

Chen ZG,Zhang TT,Li HT,Chen FH,Zou XL,Ji JZ,Chen H

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Tue Aug 20 00:00:00 EDT 2013

Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice.

PloS one

Kamphuis T,Meijerhof T,Stegmann T,Lederhofer J,Wilschut J,de Haan A

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Wed Sep 19 00:00:00 EDT 2012

Dynamics of lung macrophage activation in response to helminth infection.

Journal of leukocyte biology

Siracusa MC,Reece JJ,Urban JF,Scott AL

Published figure using CD80 (B7-1) monoclonal antibody (Product # 48-0801-82) in Flow Cytometry

Mon Dec 01 00:00:00 EST 2008

Bioinformatics

Protein Aliases: Activation B7-1 antigen; B7; B7 protein; B7-1 protein; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); sCD 80; sCD80; soluble CD 80; soluble CD80; T-cell co-stimulatory protein B7-1; T-cell costimulatory molecule; T-lymphocyte activation antigen CD80; TS/A-1

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Gene Aliases: B7; B7-1; B71; Cd28l; Cd80; Ly-53; Ly53; MIC17; TSA1

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UniProt ID: (Mouse) Q00609

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Entrez Gene ID: (Pig) 397161, (Dog) 403765, (Mouse) 12519

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Function(s)

protein binding immunoglobulin receptor superfamily

Process(es)

T cell costimulation positive regulation of T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation cellular response to lipopolysaccharide

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CD80 (B7-1) Monoclonal Antibody (16-10A1), eFluor™ 450, eBioscience™

CD80 (B7-1) Antibody (48-0801-82) in Flow

Product Details

48-0801-82

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

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