Invitrogen

CD98 Polyclonal Antibody

CD98 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD98 Antibody (PA5-96401) in IHC (P)

Immunohistochemistry analysis of CD98 in paraffin-embedded human placenta. Samples were incubated with CD98 Polyclonal antibody (Product # PA5-96401) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

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Product Details

PA5-96401

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 206-630 of human SLC3A2/CD98hc (NP_002385.3).

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.66 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2808203

Product Specific Information

Immunogen sequence: RAPRCRELPA QKWWHTGALY RIGDLQAFQG HGAGNLAGLK GRLDYLSSLK VKGLVLGPIH KNQKDDVAQT DLLQIDPNFG SKEDFDSLLQ SAKKKSIRVI LDLTPNYRGE NSWFSTQVDT VATKVKDALE FWLQAGVDGF QVRDIENLKD ASSFLAEWQN ITKGFSEDRL LIAGTNSSDL QQILSLLESN KDLLLTSSYL SDSGSTGEHT KSLVTQYLNA TGNRWCSWSL SQARLLTSFL PAQLLRLYQL MLFTLPGTPV FSYGDEIGLD AAALPGQPME APVMLWDESS FPDIPGAVSA NMTVKGQSED PGSLLSLFRR LSDQRSKERS LLHGDFHAFS AGPGLFSYIR HWDQNERFLV VLNFGDVGLS AGLQASDLPA SASLPAKADL LLSTQPGREE GSPLELERLK LEPHEGLLLR FPYAA

Positive Samples: 293T, MCF7, SW480, SKOV3, Mouse kidney, Mouse lung, Mouse testis, Mouse ovary; Cellular Location: Apical cell membrane, Melanosome, Single-pass type II membrane protein

Target Information

CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis.

Nutrients

Hao Z,Xu G,Yuan M,Tan R,Xia Y,Liu Y,Yin X

Published figure using CD98 polyclonal antibody (Product # PA5-96401) in Western Blot

Sat Sep 17 00:00:00 EDT 2022

The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis.

Diabetes, metabolic syndrome and obesity : targets and therapy

Zhou Y

PA5-96401 was used in Western Blotting to show that CCA exerted excellent antidiabetic effects via inhibition of ferroptosis, so it may be a promising agent for diabetes therapy, providing a new avenue for diabetes treatment.

Fri Apr 15 00:00:00 EDT 2022

Bioinformatics

Protein Aliases: 4F2 cell-surface antigen heavy chain; 4F2 heavy chain antigen; 4F2hc; Amino acid transporter heavy chain SLC3A2; antigen defined by monoclonal antibody 4F2, heavy chain; antigen identified by monoclonal antibodies 4F2; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43; CD98; CD98 antigen; CD98 heavy chain; Lymphocyte activation antigen 4F2 large subunit; monoclonal antibody 44D7; slc3a2 {ECO:0000312|RGD:3073}; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; solute carrier family 3 (amino acid transporter heavy chain), member 2; Solute carrier family 3 member 2; solute carrier family 3, member 2; type II transmembrane protein

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Gene Aliases: 4F2; 4F2HC; 4T2HC; AI314110; CD98; CD98HC; Ly-10; Ly-m10; Ly10; MDU1; Mgp-2hc; NACAE; SLC3A2

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UniProt ID: (Human) P08195, (Mouse) P10852, (Rat) Q794F9

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Entrez Gene ID: (Human) 6520, (Mouse) 17254, (Rat) 50567

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Function(s)

double-stranded RNA binding catalytic activity calcium:sodium antiporter activity protein binding neutral amino acid transmembrane transporter activity poly(A) RNA binding cadherin binding involved in cell-cell adhesion cation binding

Process(es)

amino acid transmembrane transport carbohydrate metabolic process transport amino acid transport neutral amino acid transport response to exogenous dsRNA leucine import tryptophan transport calcium ion transport cell growth sodium ion transmembrane transport leukocyte migration cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD98 Polyclonal Antibody

CD98 Antibody (PA5-96401) in IHC (P)

Product Details

PA5-96401

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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