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Product Details
PA5-88399
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human CDH11 (NP_0017882)
Conjugate
Form
Liquid
Concentration
1.55 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804882
Product Specific Information
Positive Samples: U-87MG, A-549, HT-29; Cellular Location: Cell membrane, Single-pass type I membrane protein
Immunogen sequence: ERAQYTLMAQ AVDRDTNRPL EPPSEFIVKV QDINDNPPEF LHETYHANVP ERSNVGTSVI QVTASDADDP TYGNSAKLVY SILEGQPYFS VEAQTGIIRT ALPNMDREAK EEYHVVIQAK DMGGHMGGLS GTTKVTITLT DVNDNPPKFP QSVYQMSVSE AAVPGEEVGR VKAKDPDIGE NGLVTYNIVD GDGMESFEIT TDYETQEGVI KLKKPVDFET KRAYSLKVEA ANVHIDPKFI SNGPFKDTVT VKISVEDADE PPMFLAPSYI HEVQENAAAG T
Target Information
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type I cadherins, including cadherins E (epithelial), N (neural), P (placental), and R (retinal) cadherin differ from type I cadherins in their specific amino acid sequences. Type II cadherins include human cadherin-5, -6, -8, -11, and -12. Type II cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of Cadherin-11 has been noted in brain, spinal cord, bone marrow and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. A variant Cadherin-11 gene (variant form) encodes a truncated protein with an unusual cytoplasmic domain not present in other cadherins. The variant protein is generated by alternative splicing, utilizing a 179 bp intronic sequence. Recently, Cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that Cadherin-11 may be a marker for aggressive, invasive tumor subsets.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin; cadherin 11, type 2, OB-cadherin (osteoblast); Cadherin-11; OB Cadherin; OB-cadherin; OSF-4; Osteoblast cadherin; osteoblast-cadherin
Gene Aliases: Cad-11; CAD11; CDH11; CDHOB; OB; OSF-4
UniProt ID: (Human) P55287, (Mouse) P55288
Entrez Gene ID: (Human) 1009, (Mouse) 12552
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