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Product Details
MA1-19057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Non-human primate
Published species
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
POH-1
Immunogen
Bacterially expressed full-length human Cdk1 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1075472
Product Specific Information
This antibody detects Cdk1 (p34Cdc2; an intracellular antigen). Staining of Cdk1 reflects the proliferating potential of respective tissue.
This antibody will not cross-react with Drosophila, mouse, Xenopus or rat.
Target Information
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABL1; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; Cell division protein kinase 1; Cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase
Gene Aliases: CDC2; CDC28A; CDK1; CDKN1; P34CDC2
UniProt ID: (Bovine) P48734, (Human) P06493
Entrez Gene ID: (Bovine) 281061, (Human) 983
chromatin binding
cyclin-dependent protein serine/threonine kinase activity
ATP binding
cyclin binding
Hsp70 protein binding
histone kinase activity
protein kinase activity
protein serine/threonine kinase activity
protein binding
RNA polymerase II carboxy-terminal domain kinase activity
non-receptor serine/threonine protein kinase
apoptotic process
cell proliferation
positive regulation of G2/M transition of mitotic cell cycle
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
epithelial cell differentiation
protein localization to kinetochore
regulation of circadian rhythm
negative regulation of apoptotic process
rhythmic process
cell division
Golgi disassembly
positive regulation of protein localization to nucleus
positive regulation of mitochondrial ATP synthesis coupled electron transport
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
activation of MAPK activity
microtubule cytoskeleton organization
DNA replication
DNA repair
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
mitotic nuclear envelope disassembly
mitotic G2 DNA damage checkpoint
centrosome cycle
pronuclear fusion
cell aging
response to toxic substance
positive regulation of gene expression
regulation of Schwann cell differentiation
response to organic cyclic compound
response to amine
response to activity
cell migration
chromosome condensation
organ regeneration
anaphase-promoting complex-dependent catabolic process
positive regulation of protein import into nucleus, translocation
response to drug
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
response to ethanol
positive regulation of DNA replication
positive regulation of mitotic cell cycle
regulation of embryonic development
response to cadmium ion
response to copper ion
response to axon injury
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cellular response to hydrogen peroxide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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