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CDK6 Polyclonal Antibody

CDK6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CDK6 Antibody (19117-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human endometrial cancer tissue slide using 19117-1-AP (CDK6 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CDK6 Antibody in Immunoprecipitation (IP)

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Product Details

19117-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDK6 Fusion Protein Ag5600 (1-326 aa encoded by BC027989)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEKDGLCRA DQQYECVAEI GEGAYGKVFK ARDLKNGGRF VALKRVRVQT GEEGMPLSTI REVAVLRHLE TFEHPNVVRL FDVCTVSRTD RETKLTLVFE HVDQDLTTYL DKVPEPGVPT ETIKDMMFQL LRGLDFLHSH RVVHRDLKPQ NILVTSSGQI KLADFGLARI YSFQMALTSV VVTLWYRAPE VLLQSSYATP VDLWSVGCIF AEMFRRKPLF RGSSDVDQLG KILDVIGLPG EEDWPRDVAL PRQAFHSKSA QPIEKFVTDI DELGKDLLLK CLTFNPAKRI SAYSALSHPY FQDLERCKEN LDSHLPPSQN TSELNTA (1-326 aa encoded by BC027989)

Target Information

CDK6 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene results in microcephaly 12, primary, autosomal recessive (MCPH12).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Cancer medicine

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Fri Apr 15 00:00:00 EDT 2022

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LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04.

Journal of ophthalmology

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SUN1 silencing inhibits cell growth through G0/G1 phase arrest in lung adenocarcinoma.

OncoTargets and therapy

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Wed Sep 30 00:00:00 EDT 2020

SUN1 silencing inhibits cell growth through G0/G1 phase arrest in lung adenocarcinoma.

OncoTargets and therapy

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Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.

Biotechnology and applied biochemistry

Li H,Zhou F,Du W,Dou J,Xu Y,Gao W,Chen G,Zuo X,Sun L,Zhang X,Yang S

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Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.

Biotechnology and applied biochemistry

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γ-Glutamylcyclotransferase Knockdown Inhibits Growth of Lung Cancer Cells Through G0/G1 Phase Arrest.

Cancer biotherapy & radiopharmaceuticals

Lin Z,Xiong L,Zhou J,Wang J,Li Z,Hu H,Lin Q

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γ-Glutamylcyclotransferase Knockdown Inhibits Growth of Lung Cancer Cells Through G0/G1 Phase Arrest.

Cancer biotherapy & radiopharmaceuticals

Lin Z,Xiong L,Zhou J,Wang J,Li Z,Hu H,Lin Q

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High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma.

Oncotarget

Meng D,Chen Y,Yun D,Zhao Y,Wang J,Xu T,Li X,Wang Y,Yuan L,Sun R,Song X,Huai C,Hu L,Yang S,Min T,Chen J,Chen H,Lu D

Tue Mar 10 00:00:00 EDT 2015

High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma.

Oncotarget

Meng D,Chen Y,Yun D,Zhao Y,Wang J,Xu T,Li X,Wang Y,Yuan L,Sun R,Song X,Huai C,Hu L,Yang S,Min T,Chen J,Chen H,Lu D

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Bioinformatics

Protein Aliases: Cell division protein kinase 6; CR2 protein kinase; CRK2; Cyclin-dependent kinase 6; MGC59692; Serine/threonine-protein kinase PLSTIRE

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Gene Aliases: 5830411I20; AI504062; CDK6; CDKN6; Crk2; MCPH12; PLSTIRE

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UniProt ID: (Human) Q00534, (Mouse) Q64261

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Entrez Gene ID: (Human) 1021, (Rat) 114483, (Mouse) 12571

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Function(s)

cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding cyclin binding kinase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

Process(es)

G1/S transition of mitotic cell cycle positive regulation of cell-matrix adhesion type B pancreatic cell development protein phosphorylation cell cycle arrest Notch signaling pathway negative regulation of cell proliferation response to virus regulation of gene expression positive regulation of gene expression astrocyte development dentate gyrus development lateral ventricle development T cell differentiation in thymus gliogenesis cell dedifferentiation negative regulation of cell differentiation negative regulation of myeloid cell differentiation regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of osteoblast differentiation negative regulation of cell cycle positive regulation of fibroblast proliferation generation of neurons negative regulation of epithelial cell proliferation cell division hematopoietic stem cell differentiation cellular response to phorbol 13-acetate 12-myristate regulation of cell motility negative regulation of cellular senescence hematopoietic progenitor cell differentiation phosphorylation hemopoiesis cell cycle cell differentiation regulation of cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDK6 Polyclonal Antibody

CDK6 Antibody (19117-1-AP) in IHC (P)

Product Details

19117-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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