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Product Details
CEACAM-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids within region 480-526 on human Carcinoembryonic antigen-related Cell Adhesion Molecule 1 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer with 20% glycerol, 0.5% BSA
Contains
0.01% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Product Specific Information
Quantity: 100 µg IgG per vial
Target Information
CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a; CD66a antigen
Gene Aliases: BGP; BGP1; BGPI; CEACAM1
UniProt ID: (Human) A6NE38
Entrez Gene ID: (Human) 634
angiogenesis
regulation of cell growth
blood vessel development
negative regulation of T cell mediated cytotoxicity
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of protein kinase activity
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
regulation of endothelial cell migration
regulation of phosphatidylinositol 3-kinase signaling
bile acid and bile salt transport
cell migration
regulation of cell migration
negative regulation of granulocyte differentiation
negative regulation of interleukin-1 production
cellular response to insulin stimulus
common myeloid progenitor cell proliferation
insulin receptor internalization
granulocyte colony-stimulating factor signaling pathway
regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of cytotoxic T cell degranulation
wound healing, spreading of cells
regulation of endothelial cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of T cell receptor signaling pathway
leukocyte migration
negative regulation of lipid biosynthetic process
regulation of blood vessel remodeling
regulation of ERK1 and ERK2 cascade
negative regulation of platelet aggregation
cell-cell adhesion
insulin catabolic process
regulation of homophilic cell adhesion
regulation of sprouting angiogenesis
negative regulation of hepatocyte proliferation
positive regulation of vasculogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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