Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
CEACAM1/CEACAM3/CEACAM6 Monoclonal Antibody (YTH71.3)
Product Details
MA5-17003
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rhesus monkey
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
YTH71.3
Immunogen
Human lymphocytes
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538475
Product Specific Information
This antibody does not react with mouse.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen CGM1; carcinoembryonic antigen gene family member 1; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen related cell adhesion molecule 3; carcinoembryonic antigen related cell adhesion molecule 6; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66a; CD66a antigen; CD66c; CD66d; CD66d antigen; Cluster of Differentiation 66c; Non-specific crossreacting antigen; nonspecific cross-reacting antigen; Normal cross-reacting antigen; pan CEACAM
Gene Aliases: BGP; BGP1; BGPI; CD66c; CD66D; CEA; CEACAM1; CEACAM3; CEACAM6; CEAL; CGM1; NCA; W264; W282
UniProt ID: (Human) A6NE38, (Human) P40198, (Human) P40199
Entrez Gene ID: (Human) 634, (Rhesus monkey) 708200, (Rhesus monkey) 707824, (Human) 1084, (Human) 4680, (Rhesus monkey) 106994775
angiogenesis
regulation of cell growth
blood vessel development
negative regulation of T cell mediated cytotoxicity
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of protein kinase activity
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
regulation of endothelial cell migration
regulation of phosphatidylinositol 3-kinase signaling
bile acid and bile salt transport
cell migration
regulation of cell migration
negative regulation of granulocyte differentiation
negative regulation of interleukin-1 production
cellular response to insulin stimulus
common myeloid progenitor cell proliferation
insulin receptor internalization
granulocyte colony-stimulating factor signaling pathway
regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of cytotoxic T cell degranulation
wound healing, spreading of cells
regulation of endothelial cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of T cell receptor signaling pathway
leukocyte migration
negative regulation of lipid biosynthetic process
regulation of blood vessel remodeling
regulation of ERK1 and ERK2 cascade
negative regulation of platelet aggregation
cell-cell adhesion
insulin catabolic process
regulation of homophilic cell adhesion
regulation of sprouting angiogenesis
negative regulation of hepatocyte proliferation
positive regulation of vasculogenesis
signal transduction
cell-cell signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support