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Invitrogen
CEACAM1/CEACAM5 Recombinant Rabbit Monoclonal Antibody (BLR032F)
Product Details
MA5-44259
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR032F
Immunogen
Recombinant protein representing the extracellular domain of human CEACAM1 (residues 35-433).
Conjugate
Form
Liquid
Concentration
50 µg/mL
Purification
purified
Storage buffer
BBS, pH 8.2, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
2-8°C
Shipping conditions
Wet ice
RRID
AB_2926389
Product Specific Information
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
Target Information
Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 5; CD66a; CD66a antigen; CD66e; CEA; Meconium antigen 100; pan CEACAM; sCD66e; soluble CD66e
Gene Aliases: BGP; BGP1; BGPI; CD66e; CEA; CEACAM1; CEACAM5
UniProt ID: (Human) A6NE38, (Human) P06731
Entrez Gene ID: (Human) 634, (Human) 1048
angiogenesis
regulation of cell growth
blood vessel development
negative regulation of T cell mediated cytotoxicity
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of protein kinase activity
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
regulation of endothelial cell migration
regulation of phosphatidylinositol 3-kinase signaling
bile acid and bile salt transport
cell migration
regulation of cell migration
negative regulation of granulocyte differentiation
negative regulation of interleukin-1 production
cellular response to insulin stimulus
common myeloid progenitor cell proliferation
insulin receptor internalization
granulocyte colony-stimulating factor signaling pathway
regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of cytotoxic T cell degranulation
wound healing, spreading of cells
regulation of endothelial cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of T cell receptor signaling pathway
leukocyte migration
negative regulation of lipid biosynthetic process
regulation of blood vessel remodeling
regulation of ERK1 and ERK2 cascade
negative regulation of platelet aggregation
cell-cell adhesion
insulin catabolic process
regulation of homophilic cell adhesion
regulation of sprouting angiogenesis
negative regulation of hepatocyte proliferation
positive regulation of vasculogenesis
negative regulation of myotube differentiation
homotypic cell-cell adhesion
negative regulation of apoptotic process
negative regulation of anoikis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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