Proteintech

CES1 Polyclonal Antibody

CES1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 14

CES1 Antibody (16912-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 16912-1-AP (CES1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CES1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

16912-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CES1 Fusion Protein Ag10567 (215-566 aa encoded by BC012418)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VTIFGESAG GESVSVLVLS PLAKNLFHRA ISESGVALTS VLVKKGDVKP LAEQIAITAG CKTTTSAVMV HCLRQKTEEE LLETTLKMKF LSLDLQGDPR ESQPLLGTVI DGMLLLKTPE ELQAERNFHT VPYMVGINKQ EFGWLIPMLM SYPLSEGQLD QKTAMSLLWK SYPLVCIAKE LIPEATEKYL GGTDDTVKKK DLFLDLIADV MFGVPSVIVA RNHRDAGAPT YMYEFQYRPS FSSDMKPKTV IGDHGDELFS VFGAPFLKEG ASEEEIRLSK MVMKFWANFA RNGNPNGEGL PHWPEYNQKE GYLQIGANTQ AAQKLKDKEV AFWTNLFAKK AVEKPPQTEH IEL (215-566 aa encoded by BC012418)

Target Information

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium.

Cell regeneration (London, England)

Li H,Wang X,Wang Y,Zhang M,Hong F,Wang H,Cui A,Zhao J,Ji W,Chen YG

Thu May 05 00:00:00 EDT 2022

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.

Clinical and translational medicine

Zhou L,Zhang C,Yang X,Liu L,Hu J,Hou Y,Tao H,Sugimura H,Chen Z,Wang L,Chen K

Tue Jun 01 00:00:00 EDT 2021

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.

Clinical and translational medicine

Zhou L,Zhang C,Yang X,Liu L,Hu J,Hou Y,Tao H,Sugimura H,Chen Z,Wang L,Chen K

Tue Jun 01 00:00:00 EDT 2021

Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1.

The Journal of pharmacy and pharmacology

Chen X,Yu F,Guo X,Su C,Li SS,Wu B

Mon Mar 01 00:00:00 EST 2021

Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.

Journal of proteome research

Cao Y,Ding W,Zhang J,Gao Q,Yang H,Cao W,Wang Z,Fang L,Du R

Fri May 03 00:00:00 EDT 2019

Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.

Journal of proteome research

Cao Y,Ding W,Zhang J,Gao Q,Yang H,Cao W,Wang Z,Fang L,Du R

Fri May 03 00:00:00 EDT 2019

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

Brain : a journal of neurology

Desai R,Frazier AE,Durigon R,Patel H,Jones AW,Dalla Rosa I,Lake NJ,Compton AG,Mountford HS,Tucker EJ,Mitchell ALR,Jackson D,Sesay A,Di Re M,van den Heuvel LP,Burke D,Francis D,Lunke S,McGillivray G,Mandelstam S,Mochel F,Keren B,Jardel C,Turner AM,Ian Andrews P,Smeitink J,Spelbrink JN,Heales SJ,Kohda M,Ohtake A,Murayama K,Okazaki Y,Lombès A,Holt IJ,Thorburn DR,Spinazzola A

Thu Jun 01 00:00:00 EDT 2017

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

Brain : a journal of neurology

Thu Jun 01 00:00:00 EDT 2017

Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.

British journal of pharmacology

Luo W,Xin Y,Zhao X,Zhang F,Liu C,Fan H,Xi T,Xiong J

Sat Apr 01 00:00:00 EDT 2017

Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.

British journal of pharmacology

Luo W,Xin Y,Zhao X,Zhang F,Liu C,Fan H,Xi T,Xiong J

Sat Apr 01 00:00:00 EDT 2017

Cisatracurium-induced proliferation impairment and death of colorectal cancer cells, HCT116 is mediated by p53 dependent intrinsic apoptotic pathway in vitro.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Yabasin IB,Lu Z,Yu JC,Wen Q

Sat Jul 01 00:00:00 EDT 2017

Cisatracurium-induced proliferation impairment and death of colorectal cancer cells, HCT116 is mediated by p53 dependent intrinsic apoptotic pathway in vitro.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Yabasin IB,Lu Z,Yu JC,Wen Q

Sat Jul 01 00:00:00 EDT 2017

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.

Oncotarget

Verbrugge SE,Al M,Assaraf YG,Kammerer S,Chandrupatla DM,Honeywell R,Musters RP,Giovannetti E,O'Toole T,Scheffer GL,Krige D,de Gruijl TD,Niessen HW,Lems WF,Kramer PA,Scheper RJ,Cloos J,Ossenkoppele GJ,Peters GJ,Jansen G

Tue Feb 02 00:00:00 EST 2016

Oncotarget

Tue Feb 02 00:00:00 EST 2016

Oncotarget

Tue Feb 02 00:00:00 EST 2016

Oncotarget

Tue Feb 02 00:00:00 EST 2016

Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals

Sato Y,Miyashita A,Iwatsubo T,Usui T

Sun Jul 01 00:00:00 EDT 2012

Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals

Sato Y,Miyashita A,Iwatsubo T,Usui T

Sun Jul 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: ACAT; acyl coenzyme A:cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 2 (liver); CE-1; CEH; Cholesteryl ester hydrolase; Cocaine carboxylesterase; Egasyn; HMSE; human monocyte/macrophage serine esterase 1; Liver carboxylesterase 1; Methylumbelliferyl-acetate deacetylase 1; MGC117365; Monocyte/macrophage serine esterase; REH; Retinyl ester hydrolase; Serine esterase 1; TGH; triacylglycero; Triacylglycerol hydrolase

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Gene Aliases: ACAT; CE-1; CEH; CES1; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH

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UniProt ID: (Human) P23141

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Entrez Gene ID: (Human) 1066

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Function(s)

methylumbelliferyl-acetate deacetylase activity carboxylic ester hydrolase activity esterase

Process(es)

xenobiotic metabolic process metabolic process response to toxic substance epithelial cell differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CES1 Polyclonal Antibody

CES1 Antibody (16912-1-AP) in ICC/IF

Product Details

16912-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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