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FIGURE: 1 / 1
CES1 Antibody (PA5-95959) in WB
Western blot analysis of CES1 in extracts of various cell lines. Samples were incubated with CES1 Polyclonal antibody (Product # PA5-95959) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-95959
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 287-566 of human CES1 (NP_0012574)
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2807761
Product Specific Information
Immunogen sequence: RQKTEEELLE TTLKMKFLSL DLQGDPRESQ PLLGTVIDGM LLLKTPEELQ AERNFHTVPY MVGINKQEFG WLIPMLMSYP LSEGQLDQKT AMSLLWKSYP LVCIAKELIP EATEKYLGGT DDTVKKKDLF LDLIADVMFG VPSVIVARNH RDAGAPTYMY EFQYRPSFSS DMKPKTVIGD HGDELFSVFG APFLKEGASE EEIRLSKMVM KFWANFARNG NPNGEGLPHW PEYNQKEGYL QIGANTQAAQ KLKDKEVAFW TNLFAKKAVE KPPQTEHIEL; Positive Samples: Mouse liver, A-549, U-937; Cellular Location: Endoplasmic reticulum lumen
Target Information
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACAT; acyl coenzyme A:cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 1-like; Carboxylesterase 1C; Carboxylesterase 1E; Carboxylesterase 1G; carboxylesterase 2 (liver); CE-1; CEH; Cholesteryl ester hydrolase; Cocaine carboxylesterase; Egasyn; Es-22; ES-x; esterase 1; esterase 22; esterase-22; HMSE; human monocyte/macrophage serine esterase 1; Liver carboxylesterase 1; Liver carboxylesterase 22; Liver carboxylesterase N; Lung surfactant convertase; Methylumbelliferyl-acetate deacetylase 1; MGC117365; Monocyte/macrophage serine esterase; PES-N; REH; Retinyl ester hydrolase; Serine esterase 1; TGH; triacylglycero; Triacylglycerol hydrolase
Gene Aliases: ACAT; CE-1; CEH; Ces-1; Ces-N; CES1; Ces1c; Ces1e; Ces1g; Ces1l; CES2; Ee-1; Ee1; Eg; EG244595; egasyn; Es-22; Es-4; Es-N; Es1; Es22; Es4; EsN; Gm4976; hCE-1; HMSE; HMSE1; PCE-1; PESN; REH; Ses-1; SES1; TGH
UniProt ID: (Human) P23141, (Mouse) P23953, (Mouse) Q64176, (Mouse) Q8VCC2
Entrez Gene ID: (Human) 1066, (Mouse) 244595, (Mouse) 13884, (Mouse) 13897, (Mouse) 12623
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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